International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 273, P. 132989 - 132989
Published: June 7, 2024
Language: Английский
Materials Today Chemistry, Journal Year: 2024, Volume and Issue: 41, P. 102300 - 102300
Published: Sept. 7, 2024
Language: Английский
Citations
26
Advanced Science, Journal Year: 2023, Volume and Issue: 10(16)
Published: April 10, 2023
Abstract Uncontrolled hemorrhage is still the most common cause of potentially preventable death after trauma in prehospital settings. However, there rarely are hemostatic materials that can achieve safely and efficiently rapid hemostasis simultaneously. Here, new carbonized cellulose‐based aerogel material developed for management noncompressible torso hemorrhage, intractable issue uncontrolled hemorrhage. The cellulose derived from Agaricus bisporus a series processing, including cutting, carbonization, purification, freeze‐drying. In vitro, aerogels with porous structure show improved hydrophilicity, good blood absorption, coagulation ability, shape recoverable ability under wet conditions. And vivo, effective both small big animal serious models. amount loss time all better than positive control group. Moreover, mechanism studies reveal associated high hemoglobin binding efficiency, red cell platelets absorption activation. Together, this study could be promising
Language: Английский
Citations
32
Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(7)
Published: Oct. 31, 2023
Abstract MXene‐based aerogels are promising candidates for wearable electronics due to their unique structures and properties. However, the reported show poor stretchability, significantly restricting applications in electronics. Herein, unprecedented highly stretchable with crimpled reentrant microstructures developed via synergistic assembly of MXene flexible polymers combined uniaxial biaxial hot‐pressing strategies. The uniaxially hot‐pressed meta‐aerogels compressed combine ultrahigh stretchability up 427%, high elasticity, compressibility, fatigue resistance upon compression stretching, near‐zero Poisson's ratios. biaxially exhibit achieve negative ratios stretching different directions, which have never been realized by traditional aerogels. It is demonstrated that they can be used ultrabroad‐range pressure/strain sensors, triboelectric nanogenerators, smart thermal management tunable insulation Joule heating performances achieved stretching. This work opens a new way electronics, management, energy storage, etc.
Language: Английский
Citations
26
Advanced Composites and Hybrid Materials, Journal Year: 2024, Volume and Issue: 7(2)
Published: April 1, 2024
Language: Английский
Citations
13
Advanced Science, Journal Year: 2024, Volume and Issue: 11(19)
Published: March 13, 2024
Abstract Uncontrollable massive bleeding caused by trauma will cause the patient to lose a large amount of blood and drop body temperature quickly, resulting in hemorrhagic shock. This study aims develop hemostatic product for hemorrhage management. In this study, waste pomelo peel as raw material is chosen. It underwent processes carbonization, purification, freeze‐drying. The obtained carbonized (CPP) hydrophilic exhibits porous structure (nearly 80% porosity). water/blood absorption ratio significantly faster than commercial Gelfoam has similar capacity. addition, CPP showed water‐triggered shape‐recoverable ability. Moreover, shows ideal cytocompatibility compatibility vitro favorable tissue after long terms subcutaneous implantation. Furthermore, can absorb red cells fibrin. also platelets activate platelets, it capable achieving rapid hemostasis on rat tail amputation hepatectomized model. not only quickly stop liver‐perforation rabbit heart uncontrolled models, but promotes liver regeneration situ. These results suggest shown great potential managing hemorrhage.
Language: Английский
Citations
11
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 260, P. 129454 - 129454
Published: Jan. 16, 2024
Persistent bleeding and the absence of alveolar bone stress following tooth loss can hinder socket healing, complicating future dental implant procedures, potentially leading to neighboring instability. Therefore, developing materials that promote regeneration possess both hemostatic osteogenic properties is crucial for preserving extraction sites. This study introduces a silk-based laponite composite scaffold material with proficient functions, excellent shape-memory efficient extraction- site filling. In vitro studies research demonstrated scaffold's inherent negative charge significantly enhanced blood coagulation thrombin generation. Moreover, its porous structure slightly rough inner surface promoted cell adhesion and, improved performance. Furthermore, facilitated stem differentiation by activating TRPM7 channel through released magnesium ions. vivo tests using rat models confirmed effectiveness in promoting mandibular regeneration. Thus, this proposes promising approach post-extraction regenerative repair. The material, capabilities features, enhance success overall oral health.
Language: Английский
Citations
9
Bioactive Materials, Journal Year: 2024, Volume and Issue: 38, P. 154 - 168
Published: April 30, 2024
Effective therapies are urgently needed to stabilize patients with marginally compressible junctional hemorrhage long enough get them the hospital alive. Herein, we report injectable and rapidly expandable cryogels consisting of polyacrylamide thrombin (AT cryogels) created by cryo-polymerization for efficient management lethal in swine. The produced have small pore sizes highly interconnected porous architecture robust mechanical strength. exhibit rapid shape memory properties prove be resilient against fatigue. These also show high water/blood absorption capacity, fast blood clotting effect, enhanced adhesion red cells platelets vitro. Further, vivo, hemostatic efficacy tests a swine model suggest that treatment AT cryogels, especially AT-2 achieves least loss highest survival rate (100 %) compared currently employed products such as XStat® combat gauze. performance may attributed size use pro-coagulant agent. Collectively, thrombin-decorated polyacrylamide-based significant promise material, offering effective hemorrhages prehospital settings.
Language: Английский
Citations
9
Biomaterials, Journal Year: 2023, Volume and Issue: 302, P. 122347 - 122347
Published: Oct. 4, 2023
Language: Английский
Citations
17
Nano Research, Journal Year: 2024, Volume and Issue: 17(10), P. 8842 - 8862
Published: Jan. 12, 2024
Language: Английский
Citations
8
Molecules, Journal Year: 2024, Volume and Issue: 29(8), P. 1888 - 1888
Published: April 21, 2024
Dragon’s blood (DB) is a traditional Chinese medicine (TCM) with hemostatic effects and antibacterial properties. However, it still challenging to use for rapid hemostasis because of its insolubility. In this study, different amounts DB were loaded on mesoporous silica nanoparticles (MSNs) prepare series DB-MSN composites (5DB-MSN, 10DB-MSN, 20DB-MSN). could quickly release activate the intrinsic coagulation cascade simultaneously by MSN. Hemostasis tests demonstrated that showed superior than either or MSNs alone, 10DB-MSN exhibited best effect. addition, activities against Staphylococcus aureus (S. aureus) Escherichia coli (E. coli) improved increase in DB. Furthermore, hemolysis assay cytocompatibility all DB-MSNs excellent biocompatibility. Based these results, expected have potential applications emergency treatment pre-hospital trauma.
Language: Английский
Citations
5