Laponite nanoparticle-crosslinked carboxymethyl cellulose-based injectable hydrogels with efficient underwater-specific adhesion for rapid hemostasis

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 255, P. 128288 - 128288

Published: Nov. 21, 2023

Language: Английский

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A self-elastic chitosan sponge integrating active and passive hemostatic mechanisms for effectively managing uncontrolled coagulopathic hemorrhage

Materials Today Bio, Journal Year: 2024, Volume and Issue: 26, P. 101031 - 101031

Published: March 23, 2024

Developing a self-elastic sponge integrating active and passive hemostatic mechanisms for the effective management of uncontrolled coagulopathic hemorrhage remains challenge. We here developed chitosan-based by freeze-drying, chemical decoration alkyl chains phosphate groups, physical loading thrombin. The exhibited high mechanical strength, self-elasticity, rapid shape recovery. facilitated blood cell adhesion, aggregation, activation through hydrophobic electrostatic interactions, as well accelerated clotting. higher efficacy than commercial gauze gelatin in managing from heparinized rat tail amputation, liver superficial injury, perforating wound models. In addition, favorable biodegradability biocompatibility. These findings revealed that holds great potential novel hemostat effectively wounds.

Language: Английский

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Intelligent and biocompatible cellulose aerogels featured with high-elastic and fast-hemostatic for epistaxis and wound healing

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 277, P. 134239 - 134239

Published: Oct. 1, 2024

Language: Английский

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An intelligent biomass aerogel label loaded with anthocyanin from wasted peanut seed coat for monitoring chilled chicken freshness

Food Hydrocolloids, Journal Year: 2024, Volume and Issue: 160, P. 110731 - 110731

Published: Oct. 11, 2024

Language: Английский

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Rapid Fluid-Induced-Expanding Chitosan-Derived Hemostatic Sponges with Excellent Antimicrobial and Antioxidant Properties for Incompressible Hemorrhage and Wound Healing

Biomacromolecules, Journal Year: 2025, Volume and Issue: 26(1), P. 689 - 704

Published: Jan. 1, 2025

Chitosan-based materials are known for their excellent biocompatibility and inherent hemostatic properties. However, efficiency is significantly affected by poor wettability mechanical strength. Herein, we developed a novel super elastic sponge from mussel-inspired chitosan modified with long alkyl catechol functional groups (HMCC) via simple freezing-drying procedure. The incorporation of decanal in the HMCC enhances its antimicrobial antioxidant properties facilitates multiple interactions blood cells, thus promoting enrichment rapid hemostasis. Moreover, sponges exhibit high compressibility fluid-induced size recovery capacity, enabling wound shape adaptation to ensure minimizing irritation. In vivo experiments revealed that possessed enhanced procoagulant, hemostasis abilities, favorable degradability could promote healing rat skin model. These results highlight potential as promising solution clinical management major bleeding.

Language: Английский

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SiO2-based inorganic nanofiber aerogel with rapid hemostasis and liver wound healing functions

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Bicomponent nano- and microfiber aerogels for effective management of junctional hemorrhage

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 11, 2025

Abstract Managing junctional hemorrhage is challenging due to ineffective existing techniques, with the groin being most common site, accounting for approximately 19.2% of potentially survivable field deaths. Here, we report a bicomponent nano- and microfiber aerogel (NMA) injection into deep, narrow wounds effectively halt bleeding. The comprises intertwined poly(lactic acid) nanofibers poly(ε-caprolactone) microfibers, mechanical properties tunable through crosslinking. Optimized aerogels demonstrate improved resilience, toughness, elasticity, enabling rapid re-expansion upon blood contact. They superior absorption clotting efficacy compared commercial products (i.e., QuikClot® Combat Gauze XStat®). Most importantly, in lethal swine wound model (Yorkshire swine, both male female, n = 5), treatment achieved immediate hemostasis, 100% survival rate, no rebleeding, hemodynamic stability, stable coagulation, hematologic, arterial gas testing.

Language: Английский

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Effect of tranexamic acid-functionalized photothermal hydrothermal treated oxidized graphene sponge on diabetic wound healing: Hemostasis, antibacterial, and regeneration

Materials & Design, Journal Year: 2025, Volume and Issue: unknown, P. 113915 - 113915

Published: April 1, 2025

Language: Английский

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In Vitro Hemostatic Activity of Novel Fish Gelatin–Alginate Sponge (FGAS) Prototype

Polymers, Journal Year: 2024, Volume and Issue: 16(14), P. 2047 - 2047

Published: July 18, 2024

A hemostatic sponge prototype was successfully synthesized from fish gelatin as an alternative to mammalian gelatin; it mixed with alginate in certain combinations, double cross-linked calcium ions, and gamma irradiated at a dose of 20 kGy improve the characteristics effectiveness its function local agent. There were improvements physicochemical mechanical properties, porosity index, absorption capacity, biodegradation biocompatibility, hemocompatibility gelatin–alginate (FGAS) prototypes compared pure sponge. Hemostatic activity tests showed that means for clotting time, prothrombin activated partial thromboplastin time shorter FGAS than negative control, there no significant difference commercial The mechanism combined passive concentrator factor active through release ions coagulation cascade process.

Language: Английский

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Carbon Nanotube Reinforced Carbonized Cellulose Aerogels for Enhanced Hemostasis and Accelerated Skin Wound Healing

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Abstract Trauma from car accidents and other causes can result in severe bleeding significant skin defects. Current biomaterials still face challenges achieving rapid hemostasis to stabilize life‐threatening conditions subsequently promoting the complete repair of tissue. This study develops a carbon nanotube (CNT)‐reinforced carbonized cellulose aerogel for managing fatal, uncontrolled enhancing wound healing. These aerogels demonstrate high porosity with large pore sizes, appropriate hydrophilicity, excellent shape recovery after compression. In vitro, composite show good cytocompatibility blood compatibility. Not only do they absorb substantial amounts adhered red cells platelets, but also activate platelets. vivo, outperform clinically used gauze gelatin sponges hemostatic capacity rat tail amputation liver perforation hemorrhage models. Moreover, this work discovers that photothermal effect could accelerate clot formation, enhance mechanical properties formed clot. Additionally, promote healing, results comparable widely commercial dressing, PELNAC. The temperature generated by formation local supply. Overall, presents promising strategy treating uncontrollable

Language: Английский

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