Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101322 - 101322
Published: Nov. 1, 2024
Language: Английский
Smart Medicine, Journal Year: 2024, Volume and Issue: 3(2)
Published: March 7, 2024
The islet of Langerhans, functioning as a "mini organ", plays vital role in regulating endocrine activities due to its intricate structure. Dysfunction these islets is closely associated with the development diabetes mellitus (DM). To offer valuable insights for DM research and treatment, various approaches have been proposed create artificial or organoids high similarity natural islets, under collaborative effort biologists, clinical physicians, biomedical engineers. This review investigates design fabrication considering both biological tissue engineering aspects. It begins by examining structures functions native proceeds analyze protocols generating from stem cells. also outlines techniques used crafting specific focus on hydrogel-based ones. Additionally, it provides concise overview materials devices employed applications islets. Throughout, primary goal develop thereby bridging realms developmental biology, medicine, engineering.
Language: Английский
Citations
3
Aggregate, Journal Year: 2024, Volume and Issue: 5(4)
Published: March 31, 2024
Abstract Microfibers from natural products are endowed with remarkable biocompatibility, biodegradability, sustainable utilization as well environmental protection characteristics etc. Benefitting these advantages, microfibers have demonstrated their prominent values in biomedical applications. This review comprehensively summarizes the relevant research progress of and To begin, common elements introduced for microfiber fabrication. After that, focus is on specific fabrication technology process. Subsequently, applications discussed detail. Last but not least, main challenges during development process summarized, followed by a vision future opportunities.
Language: Английский
Citations
3
ACS Materials Letters, Journal Year: 2025, Volume and Issue: unknown, P. 1462 - 1487
Published: March 20, 2025
Language: Английский
Citations
0
Research, Journal Year: 2024, Volume and Issue: 7
Published: Jan. 1, 2024
Natural biomaterials have been showing extensive potential in wound healing; attempts therefore focus on productions achieving both antimicrobial and tissue regenerative abilities. Here, we construct a decellularized human colon tumor (DHCT)-derived scaffold for remolding via microfluidic bioprinting. The DHCT retains series of growth factors, fibrin, the collagen configuration, that favor repair reconstruction. Specifically, shows superior abilities cell migration angiogenesis. biocompatible is also imparted with adhesion ability photothermal effect due to coating biologically derived polydopamine surface. strong under near-infrared irradiation present an antibacterial rate exceeding 90%. Furthermore, vivo experiments convinced polydopamine-integrated can markedly expedite healing process acute wounds. These findings indicate composite materials from natural tumors substantial pertinent clinical applications.
Language: Английский
Citations
2
Journal of Tissue Engineering, Journal Year: 2024, Volume and Issue: 15
Published: Jan. 1, 2024
Traumatic injuries to the peripheral nervous system (PNI) can lead severe consequences such as paralysis. Unfortunately, current treatments rarely allow for satisfactory functional recovery. The high healthcare costs associated with PNS injuries, worker disability, and low patient satisfaction press alternative solutions that surpass standards. For treatment of a deficit less than 30 mm bridge, use synthetic nerve conduits (NGC) is favored. However, develop promising therapeutic strategies,
Language: Английский
Citations
2
ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(9), P. 5823 - 5840
Published: Aug. 15, 2024
Hydrogel microfibers are hydrogel materials engineered into fiber structures. Techniques such as wet spinning, microfluidic and 3D bioprinting often used to prepare due their ability precisely control the size, morphology, structure of microfibers. Microfibers with different structural morphologies have functions; they provide a flow-through culture environment for cells improve viability, can also be induce differentiation skeletal muscle cardiac eventually form functional organs in vitro through special morphologies. This Review introduces recent advances microfluidics, bioprinting, spinning preparation microfibers, focusing on fabrication methods. The applications tissue engineering highlighted by summarizing contributions biomimetic blood vessels, vascularized tissues, bone, heart, pancreas, kidney, liver, fat. Furthermore, fibers repair drug screening discussed.
Language: Английский
Citations
2
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 136738 - 136738
Published: Oct. 20, 2024
Language: Английский
Citations
2
ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(10), P. 4412 - 4420
Published: Aug. 26, 2024
The vessel-on-a-chip has shown a significant preponderance in vascular disease research. While the rarely demonstrated effects of endogenous and/or exogenous stimuli on endothelial glycocalyx that plays critical role regulating vessel function. Here, an innovative combined with inverse opal films was developed to investigate integrity and its barrier function under different stimuli. By integrating into chip, we achieved real-time observation vitro. We can be maintained physiological shear stress, further, restoration treated sevoflurane after being destroyed by low stress also confirmed. Thus, it is clear system holds considerable promise for studying mechanisms various diseases provides valuable candidate preclinical drug assessment.
Language: Английский
Citations
1
Science Bulletin, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
Citations
1
Seminars in Cancer Biology, Journal Year: 2024, Volume and Issue: 109, P. 10 - 24
Published: Dec. 25, 2024
Pancreatic ductal adenocarcinoma (PDAC) has one of the worst prognoses all common solid cancers. For large majority PDAC patients, only systemic therapies with very limited efficacy are indicated. In addition, immunotherapies have not brought advances seen in other cancer types. Several key characteristics contribute to poor treatment outcomes, and this review, we will discuss how these best captured currently available ex vivo or vitro model systems. instance, is hallmarked by a highly desmoplastic immune-suppressed tumor microenvironment that impacts disease progression therapy resistance. Also, differences biology exist between within tumors, complicating decisions. Furthermore, high propensity for locally invasive metastatic growth. The use animal models often desirable feasible several systems been developed, such as organotypic cocultures tissue slices, among others. However, absence full host organism ability accurately capture outcomes PDAC. We caveats advantages context PDAC's provide recommendations on choice possibilities optimization. These considerations should be researchers aiming study setting.
Language: Английский
Citations
0