Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 17, 2025
The
complicated
environment
of
the
oral
cavity
presents
significant
challenges
to
traditional
antibacterial
approaches,
which
has
driven
exploration
novel
therapeutic
strategies.
Metal-based
nanomaterials
(MNMs),
with
diverse
mechanisms
(e.g.,
membrane
disruption,
oxidative
stress)
and
evolution
from
empirical
theory-guided
design,
exhibit
immense
potential.
This
review
introduces
pioneering
Hierarchical
Response
Strategy
Framework,
systematically
classifying
MNM
systems
into
three
progressive
levels:
Primary
category,
comprising
MNMs
that
exert
spontaneous
effects
based
on
inherent
physicochemical
properties
ion
release);
Secondary
including
precisely
controlled
actions
by
microenvironmental
or
stimulus-responsive
light-induced
ROS);
Tertiary
encompassing
integrate
regenerative
functions
for
multidimensional
therapy
remineralization).
Through
this
framework,
authors
elucidate
MNMs'
transition
single-function
precision-controlled,
multifunctional
synergy,
analyze
impact
metal
elements
structural
design
efficacy,
summarize
their
applications
in
dental
caries,
endodontic
infections,
periodontal
disease,
etc.
framework
offers
a
perspective
existing
research
theoretical
foundation
rational
next-generation
precise,
smart,
comprehensive
anti-infective
materials.
Journal of Composites Science,
Journal Year:
2025,
Volume and Issue:
9(3), P. 140 - 140
Published: March 17, 2025
Since
tooth
loss
is
a
common
problem
in
humans
and
widespread
worldwide,
dental
implants
are
an
effective
optimal
alternative
to
solve
this
problem.
Thus,
it
necessary
develop
with
improved
surfaces
that
favor
the
osseointegration
of
implant
into
surrounding
tissues
promote
cell
adhesion
proliferation
while
also
preventing
inhibiting
peri-implant
infections
can
lead
failure.
In
regard,
review
aims
provide
new
insights
nanotechnology
use
nanoparticles
creating
coatings,
trends
for
enhancing
surfaces,
current
technologies
used
purpose.
Although
vitro
vivo
tests
attest
possible
nanomaterials
described
review,
further
needed
establish
concentrations
be
safe
clinical
trials.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 17, 2025
The
complicated
environment
of
the
oral
cavity
presents
significant
challenges
to
traditional
antibacterial
approaches,
which
has
driven
exploration
novel
therapeutic
strategies.
Metal-based
nanomaterials
(MNMs),
with
diverse
mechanisms
(e.g.,
membrane
disruption,
oxidative
stress)
and
evolution
from
empirical
theory-guided
design,
exhibit
immense
potential.
This
review
introduces
pioneering
Hierarchical
Response
Strategy
Framework,
systematically
classifying
MNM
systems
into
three
progressive
levels:
Primary
category,
comprising
MNMs
that
exert
spontaneous
effects
based
on
inherent
physicochemical
properties
ion
release);
Secondary
including
precisely
controlled
actions
by
microenvironmental
or
stimulus-responsive
light-induced
ROS);
Tertiary
encompassing
integrate
regenerative
functions
for
multidimensional
therapy
remineralization).
Through
this
framework,
authors
elucidate
MNMs'
transition
single-function
precision-controlled,
multifunctional
synergy,
analyze
impact
metal
elements
structural
design
efficacy,
summarize
their
applications
in
dental
caries,
endodontic
infections,
periodontal
disease,
etc.
framework
offers
a
perspective
existing
research
theoretical
foundation
rational
next-generation
precise,
smart,
comprehensive
anti-infective
materials.
