Deep Penetrating and Sensitive Targeted Magnetic Particle Imaging and Photothermal Therapy of Early‐Stage Glioblastoma Based on a Biomimetic Nanoplatform

Advanced Science, Journal Year: 2023, Volume and Issue: 10(19)

Published: May 7, 2023

Abstract Early diagnosis can effectively improve the survival of glioblastoma multiforme (GBM). A specific imaging technique that is simultaneously deep penetrating and sensitive to small tissue changes desired identify GBM. Due its excellent features in signal contrast, detection sensitivity, none or little attenuation tissue, magnetic particle (MPI) possesses great potential cancer diagnosis, especially when modality equipped with specifically targeted nanoprobes. However, gliomas are small, blood–brain barrier (BBB) complete prevents nanoprobes from entering brain, which negates theranostic effect. This study proposes a biomimetic nanoplatform assist MPI tracers breaking through BBB then demonstrate Afterward, photothermal therapy immune regulation show an therapeutic effect on It experimentally confirmed does not decay depth shows sensitivity for thousands‐cells. Only animals conducted this due limitations current commercial scanner, however, research theoretically enables large animal human studies, encourages promising pathway toward noninvasive early‐stage GBM clinics.

Language: Английский

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Self‐Assembled Aza‐Boron‐Dipyrromethene‐Based H₂S Prodrug for Synergistic Ferroptosis‐Enabled Gas and Sonodynamic Tumor Therapies

Advanced Science, Journal Year: 2024, Volume and Issue: 11(30)

Published: June 13, 2024

Glioblastoma multiforme (GBM) is the most aggressive and lethal subtype of gliomas central nervous system. The efficacy sonodynamic therapy (SDT) against GBM significantly reduced by expression apoptosis-inhibitory proteins in cells. In this study, an intelligent nanoplatform (denoted as Aza-BD@PC NPs) based on aza-boron-dipyrromethene dye phenyl chlorothionocarbonate-modified DSPE-PEG molecules developed for synergistic ferroptosis-enabled gas (GT) SDT GBM. Once internalized cells, NPs showed effective cysteine (Cys) consumption Cys-triggered hydrogen sulfide (H

Language: Английский

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Magnetic Particle Imaging Reveals that Iron-Labeled Extracellular Vesicles Accumulate in Brains of Mice with Metastases

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(24), P. 30860 - 30873

Published: June 11, 2024

The incidence of breast cancer remains high worldwide and is associated with a significant risk metastasis to the brain that can be fatal; this due, in part, inability therapeutics cross blood–brain barrier (BBB). Extracellular vesicles (EVs) have been found BBB further used deliver drugs tumors. EVs from different cell types appear patterns accumulation retention as well efficiency bioactive cargo delivery recipient cells body. Engineering tools treat metastases, therefore, will require an understanding timing EV their localization relative metastatic sites. Magnetic particle imaging (MPI) sensitive quantitative method directly detects superparamagnetic iron. Here, we demonstrate MPI novel tool characterize biodistribution disease after labeling iron oxide (SPIO) nanoparticles. Iron-labeled (FeEVs) were collected iron-labeled parental primary 4T1 tumor brain-seeking 4T1BR5 cells, followed by injection into mice orthotopic tumors or metastases. quantification revealed FeEVs retained for longer mammary carcinomas compared SPIOs. signal due could only detected brains bearing metastases FeEVs, but not SPIOs, when did These findings indicate potential use therapeutic

Language: Английский

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A CLDN18.2‐Targeted Nanoplatform Manipulates Magnetic Hyperthermia Spatiotemporally for Synergistic Immunotherapy in Gastric Cancer

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Abstract Precision treatment of gastric cancer requires specific biomarkers, and CLDN18.2 emerges as a promising target for patients’ stratification therapeutic guidance. In 563 cases, 54.4% patients are identified CLDN18.2‐positive, with expression negatively correlated immune‐related factors like PD‐L1, indicating “cold” tumor microenvironment. Here, novel monoclonal antibody 1D5 is created superior high specificity affinity, the antibody‐dependent fluorescence‐magnetic nanoparticle developed detection magnetic hyperthermia (MHT). Under assistance sensitive fluorescence deep‐penetrating particle imaging tracing timing optimal dosage, MHT induces robust immunogenic response via DNA mismatch repair tumor‐associated antigen release. It recruits CD11c + dendritic cells, compensates PD‐1 in CD8 T enhances CD86 macrophage polarization. The combination anti‐PD‐1 therapy increased TNF‐α IFN‐γ secretion further boosted cytotoxic efficacy cells. Excellent found simultaneously on cell‐derived allografts patient‐derived xenografts based this spatiotemporally manipulated strategy, presenting option enhancing responsiveness to immunotherapy CLDN18.2‐positive individuals.

Language: Английский

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Biomimetic Co‐delivery of Lenvatinib and FePt Nanoparticles for Enhanced Ferroptosis/Apoptosis Treatment of Hepatocellular Carcinoma

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Lenvatinib, endorse as a first-line targeted therapy, has demonstrated efficacy in extending the survival span of individuals afflicted with advanced Hepatocellular carcinoma (HCC). However, its therapeutic effect wears off time, which is ascribed to cancer cell's tendency evade and tamper usual modes action, severely limiting clinical use. This study devises an innovative modality involving synergistic co-delivery FePt nanoparticles (NPs) Lenvatinib via poly lactic-co-glycolic acid (PLGA) NPs encase HCC cell membranes (Len/FePt@CMP NPs). The investigation explores mechanism through induces ferroptosis HCC, notably by dampening glutathione peroxidase 4 (GPX4) inhibition fibroblast growth factor receptor 4. are engineered enhance apoptosis for treatment. Concurrently, incorporation membrane facilitates accumulation at tumor site, leveraging mechanisms immune evasion homologous targeting. enhances ferroptosis/apoptosis treatment efficacy, triggeres Len/FePt@CMP NPs, convincingly both vitro vivo. proposed approach potential redefine paradigms overcoming mono-therapeutic limitations current treatments, showcasing improved comprehensive strategy.

Language: Английский

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Hierarchical Targeting Nanoplatform for NIR‐II Photoacoustic Imaging and Photo‐Activated Synergistic Immunotherapy of Glioblastoma

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Abstract Glioblastoma (GBM) stands as the most aggressive malignant brain tumor, characterized by poor prognosis, high recurrence rate, and resistance to multiple therapies, posing a significant clinical challenge. Here, hierarchical targeting platform is presented for NIR‐II photoacoustic (PA) imaging‐guided photo‐chemo synergistic immunotherapy of GBM. A new molecular probe developed with exceptional light‐harvesting capabilities enhanced motion, boosting both photothermal conversion PA signal. This probe, combined thermo‐responsive prodrug, assembled into nanoparticles that are further camouflaged tumor cell membranes bioorthogonally modified transferrin‐mimicking peptide, facilitating blood‐brain barrier penetration GBM targeting. High‐contrast imaging allows precise detection delineation GBM, providing accurate guidance subsequent treatment. The light‐triggered effect, coupled hyperthermia‐activated significantly induces immunogenic death, enhancing tumor‐killing efficiency amplifying anti‐tumor immune response. self‐synergistic not only stimulates robust immunity inhibits primary growth but also prevents post‐surgical recurrence, prolonging survival time. work exemplifies novel paradigm tackling diagnostic therapeutic challenges posed deeply seated poorly tumors.

Language: Английский

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Diagnostics of brain tumor in the early stage: current status and future perspectives

Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The diagnostic process of brain tumors at an early stage.

Language: Английский

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Exploring the diagnostic potential: magnetic particle imaging for brain diseases

Military Medical Research, Journal Year: 2025, Volume and Issue: 12(1)

Published: April 27, 2025

Abstract Brain diseases are characterized by high incidence, disability, and mortality rates. Their elusive nature poses a significant challenge for early diagnosis. Magnetic particle imaging (MPI) is novel technique with sensitivity, temporal resolution, no ionizing radiation. It relies on the nonlinear magnetization response of superparamagnetic iron oxide nanoparticles (SPIONs), allowing visualization spatial concentration distribution SPIONs in biological tissues. MPI expected to become mainstream technology diagnosis brain diseases, such as cancerous, cerebrovascular, neurodegenerative, inflammatory diseases. This review provides an overview principles MPI, explores its potential applications discusses prospects management these

Language: Английский

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Camouflaging nanoreactor traverse the blood-brain barrier to catalyze redox cascade for synergistic therapy of glioblastoma

Biomaterials, Journal Year: 2024, Volume and Issue: 311, P. 122702 - 122702

Published: July 14, 2024

Language: Английский

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Biomimetic nanoparticle-driven strategies for targeted drug delivery in glioblastoma

Journal of Nanoparticle Research, Journal Year: 2024, Volume and Issue: 26(8)

Published: Aug. 1, 2024

Abstract Glioblastoma (GBM), the most prevalent primary brain tumor in adults, remains highly challenging due to its invasive nature, limited treatment effectiveness, and short median survival durations. Standard of care includes surgery, radiation, chemotherapy, treating fields; however, there has been little improvement rates. Biomimetic nanoparticles (NPs), coated with cell membranes endogenous components, have immense potential for improving chemotherapy GBM, by imitating cellular architecture eluding immune clearance. With more individualized efficient drug delivery, immunotherapeutic approaches biomimetic NPs may increase patient This article summarizes main research on GBM therapy, focusing classification, mechanisms, advantages, challenges, along advancements development vaccines.

Language: Английский

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