Frontiers in Oncology,
Journal Year:
2024,
Volume and Issue:
14
Published: May 24, 2024
Objective
The
purpose
of
this
study
was
to
construct
a
nomogram
model
based
on
the
general
characteristics,
histological
features,
pathological
and
immunohistochemical
results,
inflammatory
nutritional
indicators
patients
so
as
effectively
predict
overall
survival
(OS)
progression-free
(PFS)
with
non-small
cell
lung
cancer
(NSCLC)
after
surgery.
Methods
Patients
NSCLC
who
received
surgical
treatment
in
our
hospital
from
January
2017
June
2021
were
selected
subjects.
predictors
OS
PFS
evaluated
by
univariate
multivariable
Cox
regression
analysis
using
proportional
risk
model.
Based
results
multi-factor
analysis,
established
R
package.
bootstrap
method
(repeated
sampling
for
1
000
times)
used
internally
verify
model,
C-index
represent
prediction
performance
calibration
graph
visually
its
compliance,
decision
curve
(DCA)
evaluate
application
value
Results
Univariate
multivariate
analyses
identify
independent
prognostic
factors
postoperative
disease
progression
operable
patients,
values
0.927
(907–0.947)
0.944
(0.922–0.966),
respectively.
showed
that
had
high
predictive
performance.
Calibration
curves
1-year,
2-year,
3-year
show
degree
agreement
between
predicted
probability
actual
observed
probability.
In
addition,
DCA
has
good
clinical
value.
Conclusion
We
prognosis
surgery,
which
can
guide
clinicians
make
best
decision.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 8, 2025
Colorectal
cancer
(CRC)
is
one
of
the
most
common
cancers
worldwide
and
liver
metastasis
leading
reason
for
its
mortality.
Circular
RNAs
(circRNAs)
are
conclusively
associated
with
progression
various
cancers,
rendering
exploration
specific
mechanisms
in
colorectal
metastasis(CRLM)
highly
valuable.
Combined
GEO
(Gene
Expression
Omnibus)
databases
clinical
data
our
center,
we
found
that
high
expression
circSATB1
closely
related
to
CRLM.
Functionally,
could
significantly
promote
metastatic
ability
CRC
cells
vitro
vivo.
Mechanistically,
facilitated
RNF25-mediated
ubiquitylation
degradation
FKBP8,
releasing
inhibitory
effects
on
mTOR
signaling.
In
this
process,
acted
as
a
scaffold
RNF25-FKBP8
complexes.
Additionally,
be
packaged
exosomes
secreted
from
primary
tumors
into
plasma.
conclusion,
study
uncovered
new
acts
potent
promoter
CRLM
offers
novel
insights
precision
therapeutic
strategies
Cancer Immunology Immunotherapy,
Journal Year:
2025,
Volume and Issue:
74(4)
Published: Feb. 25, 2025
The
benefits
of
continuing
immunotherapy
beyond
disease
progression
in
advanced
non-small
cell
lung
cancer
(NSCLC)
and
small
(SCLC)
remain
uncertain,
along
with
the
specific
patient
subgroups
that
may
gain
most
from
this
approach.
This
retrospective
study
aims
to
evaluate
efficacy
approach
identify
target
populations
likely
benefit.
We
collected
data
patients
NSCLC
SCLC
who
experienced
following
initial
immune
checkpoint
inhibitor
(ICI)
treatment
January
2020
December
2023.
Patients
were
categorized
based
on
second-line
treatment:
those
receiving
(IBP)
non-immunotherapy
(NIBP).
Survival
outcomes
safety
compared
between
these
two
groups.
A
total
150
included,
111
(IBP:
n
=
78,
NIBP:
33)
39
31,
8).
Significant
differences
median
progression-free
survival
(PFS)
overall
(OS)
found
driver
gene-negative
(mPFS:
4.7
vs
1.3
months,
HR
0.29,
P
<
0.01;
mOS:
11.03
2.63
0.13,
0.001)
3.9
2.1
0.38,
0.02;
9.28
2.27
0.23,
0.01).
Additionally,
among
patients,
achieving
a
partial
response
(PR)
or
stable
(SD)
during
was
associated
improved
effectiveness
continued
progression.
Continued
as
benefit
have
progressed
after
immunotherapy.
Oncology Letters,
Journal Year:
2025,
Volume and Issue:
29(4), P. 1 - 11
Published: Feb. 27, 2025
During
the
development
and
progression
of
lung
cancer,
cell
metabolism
function
is
altered.
Thus,
cells
rely
on
aerobic
glycolysis
abnormal
lipid
amino
acid
to
obtain
energy
nutrients
for
growth,
proliferation
drug
resistance.
Circular
RNAs
(circRNAs),
a
class
non-coding
RNAs,
serve
important
biological
roles
in
growth
tumors.
Functionally,
circRNAs
act
as
molecular
sponges
that
absorb
microRNAs
(miRNAs)
RNA-binding
proteins
protein
scaffolds
regulate
gene
transcription
translation
through
maintenance
mRNA
stability.
In
addition,
are
regulators
tumor
promote
mediating
proliferation,
metastasis
induction
chemoresistance.
Results
previous
studies
reveal
may
key
role
regulating
metabolic
processes
miRNA
sponging
alternative
mechanisms.
demonstrate
potential
therapeutic
targets
cancer.
The
present
study
aimed
review
effects
cancer
provide
novel
insights
into
clinical
treatment
also
theoretical
basis
targets.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 17, 2025
Abstract
Chronic
obstructive
pulmonary
disease
(COPD)
is
a
characteristic
chronic
airway
inflammatory
that
worsens
over
time,
however,
there
are
currently
limited
clinical
therapeutics
to
suspend
its
progression.
Circular
RNAs
(circRNAs),
which
have
emerged
as
functional
regulators
in
various
diseases,
including
COPD,
may
server
new
pharmacological
targets
COPD.
Here,
it
identified
nuclear
circRNA,
circCANX,
preferentially
decreased
The
linear
splicing
of
CANX
pre‐mRNA,
enhanced
by
the
ADAR1‐HNRNPL
interaction,
responsible
for
circCANX
decline.
Clinically,
higher
expression
associated
with
worse
lung
function
index
FEV
1
/FVC
among
patients
CircCANX
suppresses
autophagy
and
stress
granule
(SG)
formation
strengthen
inflammation
COPD
vivo
vitro.
Mechanistically,
recruits
tumor
suppressor
protein
P53
(P53)
mRNA
RNA
helicase
upstream
frameshift
(UPF1)
form
ternary
complex,
mediates
degradation
through
nonsense‐mediated
decay
(NMD)
process.
Together,
this
study
reveals
an
important
circCANX‐mediated
regulatory
mechanism
provides
insights
into
potential
circRNA‐based
drug
biomarker
development
World Journal of Gastroenterology,
Journal Year:
2025,
Volume and Issue:
31(13)
Published: April 2, 2025
BACKGROUND
Liver
hepatocellular
carcinoma
(LIHC)
is
a
highly
aggressive
cancer
with
poor
prognosis
due
to
its
complex
tumor
microenvironment
(TME)
and
immune
evasion.
Regulatory
T
cells
(Tregs)
play
critical
role
in
progression.
Suppressor
of
cytokine
signaling
2
(SOCS2),
key
regulator,
may
modulate
Treg
activity
impact
LIHC
growth
metastasis.
AIM
To
explore
how
the
SOCS2
affects
on
METHODS
transcriptome
data
from
The
Cancer
Genome
Atlas
database
were
analyzed
using
Gene
Set
Enrichment
Analysis,
Estimation
Stromal
Immune
Cells
Malignant
Tumors
Using
Expression
Data,
Cell-Type
Identification
by
Estimating
Relative
Subsets
RNA
Transcripts
evaluate
pathways
infiltration.
Key
prognostic
genes
identified
Weighted
Co-expression
Network
Analysis
machine
learning.
In
vitro
,
co-culture
experiments,
migration
assays,
apoptosis
detection,
enzyme-linked
immunosorbent
assay
conducted.
vivo
growth,
metastasis,
assessed
subcutaneous
lung
metastasis
mouse
models
hematoxylin
eosin
staining,
Terminal
Deoxynucleotidyl
Transferase
dUTP
Nick
End
Labeling,
immunohistochemistry
analyses.
RESULTS
overexpression
inhibited
cell
activity,
reducing
invasion
while
increasing
apoptosis.
suppressed
confirming
therapeutic
potential.
CONCLUSION
modulates
CD4+
function
TME,
contributing
Targeting
presents
potential
strategy
for
treating
LIHC.
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer,
Journal Year:
2024,
Volume and Issue:
1879(2), P. 189081 - 189081
Published: Jan. 26, 2024
Distant
metastasis
is
responsible
for
high
mortality
in
most
cancer
cases
and
the
lung
one
of
common
target
organs,
severely
affecting
quality
daily
life
overall
survival
patients.
With
relevant
research
breakthroughs
accumulating,
scientists
have
developed
a
deeper
understanding
(LM)
from
rudimentary
"seed
soil"
theory
to
more
vivid
concept
pre-metastatic
niche
(PMN).
Thus,
mechanisms
PMN
formation
become
considerably
complicated,
involving
various
types
cells,
chemokines,
cytokines,
proteins,
providing
potential
biomarkers
improved
LM
diagnosis
treatment
techniques.
Here
we
summarized
latest
findings
(in
3
years)
systematically
collated
it
basic
clinical
application,
which
clearly
exhibited
influences
primary
tumor,
stromal,
bone
marrow-derived
cells
(BMDCs)
associated
molecules
PMN.
