Washed microbiota transplantation stopped recurrent sepsis in a patient with myelofibrosis: a case report DOI Creative Commons

Yingqi Yang,

Luyao Wang,

Tianchi Zhuang

et al.

Gut Pathogens, Journal Year: 2024, Volume and Issue: 16(1)

Published: Dec. 27, 2024

Sepsis represents the most prevalent infectious complication and primary cause of mortality in myeloproliferative neoplasms (MPN). The risk sepsis difficulty treatment are significantly increased MPN patients due to need for immunomodulators antibiotics. On June 9, 2023, a 69-year-old male was admitted hospital. Following battery tests, diagnosis Escherichia coli ultimately established. patient administered amoxicillin clavulanate potassium intravenously. In light patient's recurrent likelihood that source infection is intestinal tract, we advised undergo washed microbiota transplantation (WMT) via colonic transendoscopic enteral tube (TET). WMT as new method fecal (FMT) successfully cured this case, indicating novel option challenging refractory or serious infections.

Language: Английский

Bacillus paralicheniformis-mediated gut microbiota promotes M2 macrophage polarization by inhibiting P38 MAPK signaling to alleviate necrotizing enterocolitis and apoptosis in mice DOI
Shumin Yang, Huachun Pan,

Tingyang Wang

et al.

Microbiological Research, Journal Year: 2025, Volume and Issue: 296, P. 128136 - 128136

Published: March 5, 2025

Language: Английский

Citations

0
Exploring urinary microbiome: insights into neurogenic bladder and improving management of urinary tract infections DOI Creative Commons
Jinming Zhang, Yu L. Lei,

Huayong Du

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: April 1, 2025

The traditional view of sterile urine has been challenged by advancements in next-generation sequencing, revealing that the urinary microbiome significantly influences individual health and various system diseases. Urinary tract infections patients with neurogenic bladder are highly prevalent, recurrent, lifelong. If frequent not adequately managed, they may ultimately lead to chronic renal failure. excessive use antibiotics prevent treat increased bacterial resistance, limiting future therapeutic options. This review summarizes commonly used research techniques collection methods, compiles current studies on patients, discusses potential implications composition for preventing, diagnosing, treating infections. By summarizing findings, we aim enhance understanding promote standardization clinical translation research.

Language: Английский

Citations

0
Gut Microbiota-Targeted Intervention of Hyperlipidemia Using Monascus-Fermented Ginseng DOI Creative Commons
Qing Zhou,

Cuiting Yang,

Mingyue Jia

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(5), P. 661 - 661

Published: April 30, 2025

Background/Objectives: Hyperlipidemia (HLP) encompasses a spectrum of poorly understood lipid metabolism disorders that are frequently overlooked or misdiagnosed, potentially leading to multiple complications. While the gut microbiota has been implicated in HLP pathogenesis, causal relationships and molecular mechanisms remain elusive. This study aimed investigate therapeutic Monascus-fermented ginseng (MFG) on through modulation explore treatment potential via fecal transplantation (FMT). Methods: The MFG-modulated was transplanted into mice. Systemic evaluations, including serum biochemical parameter detection, histopathological section analysis, 16S rRNA sequencing, metabolomics, were conducted assess efficacy identify associated metabolic pathways. Results: FMT significantly improved profiles, reduced body weight, attenuated hepatic accumulation Mechanistically, it enhanced cholesterol excretion fatty acid β-oxidation while suppressing lipogenic regulators, concurrently promoting primary-to-secondary bile conversion. Gut analysis revealed MFG intervention effectively normalized Firmicutes/Bacteroidetes ratio enriched beneficial microbiota. Conclusions: These findings demonstrate FMT’s value management provide new perspectives utilizing fermented herbal medicines for reprogramming.

Language: Английский

Citations

0
Different Levels of Therapeutic Strategies to Recover the Microbiome to Prevent/Delay Acute Lymphoblastic Leukemia (ALL) or Arrest Its Progression in Children DOI Open Access

Tommaso Silvano Aronica,

Miriam Carella,

Carmela Rita Balistreri

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3928 - 3928

Published: March 31, 2024

Changes in the components, variety, metabolism, and products of microbiomes, particularly gut microbiome (GM), have been revealed to be closely associated with onset progression numerous human illnesses, including hematological neoplasms. Among latter pathologies, there is acute lymphoblastic leukemia (ALL), most widespread malignant neoplasm pediatric subjects. Accordingly, ALL cases present a typical dysfunctional GM during all its clinical stages resulting inflammation, which contributes progression, altered response therapy, possible relapses. Children characteristic variations composition, functions, such alterations may influence predict complications prognosis after chemotherapy treatment or stem cell hematopoietic transplants. In addition, growing evidence also reports ability formation, growth, roles newborn's system through process developmental programming fetal life as well susceptibility onco-hematological namely ALL. Here, we suggest some therapeutic strategies that can applied at two levels intervention recover consequently prevent/delay arrest progression.

Language: Английский

Citations

3
Altitude adaptation: The unseen work of gut microbiota DOI Creative Commons
Jingling Guo,

Runzhou Zhao,

Kun Li

et al.

hLife, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

2
Washed microbiota transplantation via colonic transendoscopic enteral tube rescues severe acute pancreatitis: A case series DOI Creative Commons
Changjiang Huang,

Cheng Huang,

Renfu Tian

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(13), P. e33678 - e33678

Published: June 26, 2024

BackgroundGut microbiota dysbiosis plays a significant role in the development of acute pancreatitis (AP). However, recent randomized trial reported negative findings regarding use fecal transplantation (FMT) via mid-gut tube severe AP. The case series presents feasibility washed (WMT) as new methodology FMT and its delivery colonic transendoscopic enteral tubing (TET) for AP.Case seriesWe presented two cases AP rapidly rescued using WMT TET. Symptoms related to physiology chronic health evaluation-II score improved soon after WMT. In Case 1, bilirubin infection indexes continuously decreased initial patient was successfully weaned off ventilator recovered from multiple organ system failures (MSOF) within ten days. 2, patient's consciousness one day WMT, with normal bowel sounds stable blood pressure without vasoactive drug maintenance. Both 1 2 completed follow-ups seven months twenty-two months, respectively, no reports new-onset diabetes.ConclusionWMT TET played critical therapeutic rescuing cases. This is first report providing direct evidence clinical value targeting through

Language: Английский

Citations

1
Skin Rejuvenation in Aged Mice by Fecal Transplantation Microbiota from Young Mice Feces DOI Creative Commons

Shoujuan Yu,

Ziyang Li, Xiaoxu Zhang

et al.

Engineering, Journal Year: 2024, Volume and Issue: 42, P. 26 - 38

Published: Aug. 26, 2024

Language: Английский

Citations

1
Nationwide exploration: assessing oral microbiome knowledge among dental professionals in Saudi Arabia and its implications for oral health care DOI Creative Commons
Sameena Parveen, Ahmed Shaher Alqahtani, Mohammed Y. Aljabri

et al.

BMC Oral Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Aug. 31, 2024

The relationship between the microbiome and oral health is intricate, yet there a lack of comprehensive knowledge regarding microbiome's impact on health. Integrating its significance in systemic diseases holds profound implications for dental professionals patient care professional development. This study assessed professionals' comprehension levels Saudi Arabia healthcare. Data were gathered using cross-sectional design by administering online questionnaire to 253 from diverse demographic backgrounds. questionnaire, administered English, was divided into four sections: (1) Microbiome awareness understanding, (2) Diet, nutrition, relationship, (3) diseases, (4) Counselling, education, implications. Statistical analyses used identify understand underlying patterns, including descriptive statistics, chi-squared tests, ANOVA, post hoc tests. Spearman rank correlation coefficient applied assess self-rated knowledge. Of participants, 94.6% familiar with term "microbiome." Merely 13% participants considered be second most diverse, following gut microbiome. About 39.9% knew connection mucosal Furthermore, only 6.7% thought Participant questions averaged 9.19 out 13, 83.7% scoring "good". There significant differences scores among specializations (F = 7.082, P < 0.001) years experience 4.755, 0.003). Significantly, 53.8% had uncertain self-perceptions their microbiome, while 0.8% rated understanding as 'very good'. Our findings reveal that have varying Despite widespread awareness, diversity remains limited. It essential address these gaps through future research educational interventions, considering vital part play promoting personalised dietary recommendations, lifestyle changes, hygiene practices. These initiatives may promote robust microbial community, enhance outcomes, advance healthcare locally globally.

Language: Английский

Citations

1
Freeze-dried fecal microorganisms as an effective biomaterial for the treatment of calves suffering from diarrhea DOI Creative Commons
Tomonori Nochi, Jahidul Islam,

Natsuki Ohtani

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: April 10, 2024

Abstract Fecal microbiota transplantation (FMT) is a therapeutic modality for treating neonatal calf diarrhea. Several practical barriers, including donor selection, fecal collection, and limited timeframe FMT, are the main constraints to using fresh feces implementing on-farm FMT. We report utility of FMT with pretreated ready-to-use frozen (F) or freeze-dried (FD) microorganisms In total, 19 (F-FMT, n = 10 FD-FMT, 9) treatments were conducted. Both 100% clinically effective; however, multi-omics analysis showed that FD-FMT was superior F-FMT. Machine learning SourceTracker confirmed retained four times better in recipient calves treated than A predictive model based on receiver operating characteristic curve area under more discriminative F-FMT observed changes metabolites during disease recovery. These results provide new insights into establishing methods preparing increase quality animals may contribute humans.

Language: Английский

Citations

0
Gut microbiota and sleep: Interaction mechanisms and therapeutic prospects DOI Creative Commons

Zhonghui Lin,

Tao Jiang,

Miaoling Chen

et al.

Open Life Sciences, Journal Year: 2024, Volume and Issue: 19(1)

Published: Jan. 1, 2024

Abstract Sleep is crucial for wellness, and emerging research reveals a profound connection to gut microbiota. This review explores the bidirectional relationship between microbiota sleep, exploring mechanisms involved therapeutic opportunities it presents. The gut–brain axis serves as conduit crosstalk central nervous system, with dysbiosis in impairing sleep quality vice versa . Diet, circadian rhythms, immune modulation all play part. Specific bacteria, like Lactobacillus Bifidobacterium , enhance through serotonin gamma-aminobutyric acid production, exemplifying direct microbiome influence. Conversely, deprivation reduces beneficial exacerbating dysbiosis. Probiotics, prebiotics, postbiotics, fecal transplants show potential, backed by animal human research, yet require further study on safety long-term effects. Unraveling this intricate link paves way tailored therapies, utilizing manipulation improve health. Accelerated essential fully tap into promising field disorder management.

Language: Английский

Citations

0