ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(4)
Published: Jan. 26, 2024
Abstract
We
report
the
development
of
a
convenient
organocatalytic
method
for
synthesis
5
H
‐pyrano[3,2‐
c
]chromenes
from
chromone‐containing
acrylates
and
ethyl
cyanoacetate.
The
is
characterized
by
simple
conditions
(ethanol,
basic
catalysis)
good
yields
(up
to
90
%).
synthesized
pyrano[3,2‐
are
promising
new
class
fluorescent
compounds.
They
have
intense
fluorescence
in
yellow‐green
region
spectrum
(495–554
nm)
with
high
quantum
72
%)
exhibit
large
Stokes
shifts
(3514–5856
cm
−1
).
demonstrated
possible
application
obtained
as
selective
“turn‐off”
sensors
nucleophilic
anions,
such
cyanide,
sulfide
sulfite.
ChemPhotoChem,
Journal Year:
2023,
Volume and Issue:
8(5)
Published: Dec. 14, 2023
Abstract
Fluorophores
and
fluorophores‐based
probes
or
labels
can
visualize
the
structures
content
fluctuations
of
biomolecules,
have
made
great
progress
in
broad
range
biomedicine
fields.
However,
many
commercially
available
fluorophores
suffer
from
small
Stokes
shift,
which
results
insufficient
signal‐to‐noise
ratio
self‐quenching
advanced
imaging
techniques.
Moreover,
shift
also
hinders
application
some
complex
imaging,
such
as
single‐excitation
multicolor
imaging.
In
past
two
decades,
effects
been
to
enlarge
fluorophores.
this
review,
we
clarified
reasons
for
building
on
structural
analysis
fluorophores,
systematically
summarize
methods
modification
increase
present
representative
applications
with
large
sensing.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(49)
Published: Sept. 13, 2023
We
here
disclose
that
the
incorporation
of
thiophene
rings
into
a
seven-membered
8π
azepine
in
fused
fashion
produces
useful
antiaromatic
core
for
near-infrared
(NIR)
dyes.
In
contrast
to
dibenzazepine
derivatives
with
bent
structures,
dithieno-fused
electron-accepting
groups
adopt
flat
conformations
ground
state.
The
exhibited
broad
absorption
spectra
cover
visible
region
as
well
sharp
emission
bands
NIR
region,
which
are
considerably
red-shifted
relative
those
dibenzo-fused
congeners.
Theoretical
study
revealed
two
contradictory
effects
less-aromatic
thiophene-fused
structure,
i.e.,
enhancement
antiaromaticity
adjacent
ring
and
relief
through
contribution
quinoidal
resonance
form.
combination
dithienoazepine
cationic
produced
fluorescent
dye
an
at
878
nm
solution.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(20)
Published: April 29, 2024
Emerging
organic
molecules
with
emissions
in
the
second
near-infrared
(NIR-II)
region
are
garnering
significant
attention.
Unfortunately,
achieving
accountable
emission
intensity
over
NIR-IIa
(1300
nm)
faces
challenges
due
to
intrinsic
energy
gap
law.
Up
current
stage,
all
reported
emitters
belong
polymethine-based
dyes
small
Stokes
shifts
(<50
and
low
quantum
yield
(QY;
≤0.015%).
However,
such
polymethines
have
proved
cause
self-absorption
constrained
brightness,
limiting
advanced
development
deep-tissue
imaging.
Here
a
new
scaffold
based
on
rigid
highly
conjugated
dibenzofluoran
core
terminated
by
amino-containing
moieties
that
reveal
peaks
of
1230-1305
nm
is
designed.
The
QY
at
least
10
times
higher
than
synthesized
or
extraordinarily
large
370-446
nm.
DBF-BJ
further
prepared
as
polymer
dot
demonstrate
its
vivo
3D
stereo
imaging
mouse
vasculature
1400
long-pass
filter.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 12, 2025
Abstract
Although
classical
fluorescent
dyes
feature
advantages
of
high
quantum
yield,
tunable
“OFF‐ON”
fluorescence,
and
modifiable
chemical
structures,
etc.,
their
bio‐applications
in
deep
tissue
remains
challenging
due
to
excessively
short
emission
wavelength
(that
may
lead
superficial
penetration
depth).
Therefore,
there
is
a
pressing
need
for
pushing
the
from
visible
region
NIR‐II
window.
As
representative
dye,
2′,7′‐Dichlorofluorescein
(
DCF
),
derivative
Fluorescein,
selected
rationally
engineered
develop
novel
platform,
CR‐OH
,
which
exhibits
substantial
red‐shift
region.
This
achievement
attributed
molecular
modification
strategies
that
include
extending
π‐conjugation,
enhancing
rigidity,
incorporating
strong
electron‐withdrawing
groups.
Furthermore,
based
on
this
developed
fluorescence
probe
photothermal
nanoagent
are
successfully
constructed
unlock
its
bio‐application
imaging
endogenous
O
2
·–
fluctuations
CIRI
model
first
time,
as
well
effective
therapy
4T1
tumors
with
conversion
efficiency
(44.0%).
Significantly,
work
overcomes
limitation
dyes,
effectively
unlocking
applications
diagnosis
treatment
early
disease
Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 15, 2025
The
development
of
long-wavelength
near-infrared
II
(NIR-II,
900–1700
nm)
dyes
is
highly
desirable
but
challenging.
To
achieve
both
red-shifted
absorption/emission
and
superior
in
vivo
imaging
capabilities,
a
donor–acceptor–donor
(D–A–D)
xanthene
core
was
strategically
modified
by
extending
π-conjugated
double
bonds
enhancing
electron-donating
properties.
Two
named
VIX-1250
VIX-1450
were
synthesized
exhibited
notably
peaks
at
942/1250
1098/1450
nm,
respectively.
Among
them,
demonstrated
chemo-
photostability
even
such
long
wavelengths.
Fluorescent
angiography
using
micelles
enabled
high-clarity
blood
vessel
with
remarkable
signal-to-noise
ratio
(SNR),
underscoring
that
the
dye's
large
Stokes
shift
(352
nm),
good
brightness
(13
M–1
cm–1),
wavelength
served
as
key
factors
for
high-quality
biosensing.
Additionally,
combined
ICG
dual-color
achieved
near-zero
optical
cross
talk,
enabling
different
organ
labeling.
This
study
provides
new
direction
design
organic
dyes.
The Journal of Physical Chemistry A,
Journal Year:
2025,
Volume and Issue:
129(6), P. 1599 - 1608
Published: Jan. 31, 2025
The
quest
for
color-pure
emitters
multicolor
bioimaging
as
well
ultrahigh
definition
organic
light-emitting
diodes
demands
facile
design
concepts
to
avoid
tedious
synthetic
or
computational
trial-and-error
procedures.
We
have
recently
presented
a
simple
recipe
construct
blue
emitters,
which
combines
basic
resonance
structure
and
frontier
molecular
orbital
treatments;
this
applies
multiresonant
type
allows
enlarge
the
chemical
space
toward
novel
structural
motifs.
In
current
work,
we
show
that
such
fundamental
considerations
further
apply
structurally
entirely
different
family
of
xanthene
dyes.
Opposite
related
polymethine
dye
with
small
bond
length
alternation
(BLA)
in
ground
excited
state
(S0,
S1),
however,
dyes
display
large
BLA
S0
S1,
so
overall
change
BLA,
ΔBL,
is
small.
This
gives
equally
rise
emission;
underlying
reasons
curious
behavior
are
carved
out
study.
generalization
fact
constitutes
desired
"paper
pencil"
strategy,
spanning
now
whole
visible
range.
Aggregate,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 11, 2025
ABSTRACT
Sonodynamic
therapy
(SDT)
is
an
innovative
cancer
modality
that
harnesses
the
energy
of
ultrasound
to
activate
sonosensitizers
for
producing
reactive
oxygen
species
(ROS),
culminating
in
eradication
tumor
cells.
Compared
with
photodynamic
therapy,
SDT
has
capacity
penetrate
deeply
into
biological
tissues,
thereby
holding
significant
promise
addressing
situated
or
surgically
inaccessible
tumors.
The
effectiveness
greatly
dependent
on
characteristics
sonosensitizers,
and
unlike
inorganic
organic
offer
a
more
controlled
synthesis
process
have
excellent
biocompatibility.
This
review
presents
meticulous
undertaking
categorize
elucidate
their
mechanisms
action
therapeutic
effects
context
SDT.
Design
strategies
are
also
summarized,
we
emphasize
critical
role
nanotechnology
localization,
imaging,
multimodal
synergistic
offering
approach
achieving
precise
targeting.
In
addition,
impact
delineated
when
integrated
other
oncological
modalities,
such
as
photothermal
enhance
efficacy.
Finally,
discusses
challenges
future
perspectives
advancement
clinical
within
realm
oncology.
