Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(18)
Published: April 23, 2023
Dendritic
cell
(DC)-based
cancer
immunotherapy
has
exhibited
remarkable
clinical
prospects
because
DCs
play
a
central
role
in
initiating
and
regulating
adaptive
immune
responses.
However,
the
application
of
traditional
DC-mediated
is
limited
due
to
insufficient
antigen
delivery,
inadequate
presentation,
high
levels
immunosuppression.
To
address
these
challenges,
engineered
biomaterials
have
been
exploited
enhance
immunotherapeutic
effects.
In
this
review,
vital
principal
components
that
can
effects
are
first
introduced.
The
parameters
considered
rational
design
biomaterials,
including
targeting
modifications,
size,
shape,
surface,
mechanical
properties,
which
affect
biomaterial
optimization
DC
functions,
further
summarized.
Moreover,
recent
applications
various
field
reviewed,
those
serve
as
component
delivery
platforms,
remodel
tumor
microenvironment,
synergistically
other
antitumor
therapies.
Overall,
present
review
comprehensively
systematically
summarizes
related
promotion
functions;
specifically
focuses
on
advances
designs
for
activation
eradicate
tumors.
challenges
opportunities
treatment
strategies
designed
amplify
via
discussed
with
aim
inspiring
translation
future
immunotherapies.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 8, 2024
The
emergence
of
monkeypox
has
become
a
global
health
threat
after
the
COVID-19
pandemic.
Due
to
lack
available
specifically
treatment
against
MPV,
developing
an
vaccine
is
thus
most
prospective
and
urgent
strategy.
Herein,
programmable
macrophage
vesicle
based
bionic
self-adjuvanting
(AM@AEvs-PB)
first
developed
for
defending
virus
(MPV).
Based
on
MPV-related
antigen-stimulated
macrophage-derived
vesicles,
nanovaccine
constructed
by
loading
mature
virion
(MV)-related
intracellular
protein
(A29L/M1R)
simultaneously
modifying
with
enveloped
(EV)
antigen
(B6R),
enabling
them
effectively
promote
presentation
enhance
adaptive
immune
through
self-adjuvant
Owing
synergistic
properties
coloaded
MV
EV
in
defensing
activation
ratio
antigen-presenting
cells
nearly
four
times
than
that
single
same
dose,
resulting
stronger
immunity
host.
Notably,
intramuscular
injection
uptake
AM@AEvs-PB
demonstrated
vigorous
immune-protective
effects
mouse
challenge
attempt,
offering
promising
strategy
pre-clinical
development.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(23)
Published: Feb. 15, 2024
Abstract
High‐performance
theranostic
systems
are
of
paramount
importance
for
achieving
precise
image‐guided
cancer
immunotherapy.
Here,
a
novel
nanoplatform
is
presented
that
integrates
aggregation‐induced
emission
luminogen
(AIEgen)
with
prussian
blue
(PB)
nanocatalyzer
robust
The
AIEgen
dimethylamine
substitution
demonstrates
compelling
near‐infrared
(NIR)
light‐induced
photothermal
conversion
and
photodynamic
therapy
(PDT)
capabilities.
By
incorporating
into
porous
PBNPs,
further
enveloped
within
M1
macrophage
membrane,
tumor‐specific
nanoagent
constructed.
This
strategic
integration
effectively
constrains
the
molecular
motion
AIEgen,
leading
to
amplified
NIR‐II
fluorescence
brightness
PDT
attributes.
Moreover,
PBNPs
can
catalyze
tumor‐overexpressed
H
2
O
generate
oxygen
boost
efficacy,
PB's
NIR
absorption
also
intensifies
photoacoustic
imaging
effect.
provides
comprehensive
information
photoimmunotherapy
in
orthotopic
breast
cancer‐bearing
mice.
Leveraging
its
potent
immunogenic
cell
death
effect,
not
only
significantly
inhibits
growth,
but
generates
whole‐cell
therapeutic
vaccine
protect
mice
from
tumor
rechallenge.
In
highly
malignant
post‐surgery
models,
enables
both
accurate
identification
residual
tumors
efficient
inhibition
postoperative
recurrence
pulmonary
metastasis.
study
will
offer
valuable
insights
creating
efficacious
multifaceted
protocols.
Journal of Nanobiotechnology,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: July 23, 2023
Abstract
Therapeutic
tumor
vaccines
have
attracted
considerable
attention
in
the
past
decade;
they
can
induce
regression,
eradicate
minimal
residual
disease,
establish
lasting
immune
memory
and
avoid
non-specific
adverse
side
effects.
However,
challenge
field
of
therapeutic
is
ensuring
delivery
components
to
lymph
nodes
(LNs)
activate
cells.
The
clinical
response
rate
traditional
falls
short
expectations
due
inadequate
node
delivery.
With
rapid
development
nanotechnology,
a
large
number
nanoplatform-based
LN-targeting
nanovaccines
been
exploited
for
optimizing
immunotherapies.
In
addition,
some
possess
non-invasive
visualization
performance,
which
benefit
understanding
kinetics
nanovaccine
exposure
LNs.
Herein,
we
present
parameters
nanoplatforms,
such
as
size,
surface
modification,
shape,
deformability,
affect
functions
nanovaccines.
recent
advances
nanoplatforms
with
different
promoting
are
also
summarized.
Furthermore,
emerging
LNs-targeting
nanoplatform-mediated
imaging
strategies
both
improve
targeting
performance
enhance
quality
LN
discussed.
Finally,
summarize
prospects
challenges
/or
strategies,
optimize
efficacy
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(22)
Published: March 29, 2024
The
immune
checkpoint
blockade
strategy
has
improved
the
survival
rate
of
late-stage
lung
cancer
patients.
However,
low
response
limits
immunotherapy
efficiency.
Here,
we
report
a
ROS-responsive
Fe
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(20)
Published: April 23, 2024
Abstract
Cancer
immunotherapy
recently
transforms
the
traditional
approaches
against
various
cancer
malignancies.
Immunotherapy
includes
systemic
and
local
treatments
to
enhance
immune
responses
involves
strategies
such
as
checkpoints,
vaccines,
modulatory
agents,
mimetic
antigen‐presenting
cells,
adoptive
cell
therapy.
Despite
promising
results,
these
still
suffer
from
several
limitations
including
lack
of
precise
delivery
immune‐modulatory
agents
target
cells
off‐target
toxicity,
among
others,
that
can
be
overcome
using
nanotechnology.
Mesoporous
silica
nanoparticles
(MSNs)
are
investigated
improve
aspects
attributed
advantageous
structural
features
this
nanomaterial.
MSNs
engineered
alter
their
properties
size,
shape,
porosity,
surface
functionality,
adjuvanticity.
This
review
explores
immunological
use
vehicles
for
immune‐adjuvants,
(APCs).
The
also
details
current
remodel
tumor
microenvironment
positively
reciprocate
toward
anti‐tumor
in
combination
with
other
therapies
photodynamic/thermal
therapeutic
effect
cancer.
Last,
present
demands
future
scenarios
discussed.
Acta Biomaterialia,
Journal Year:
2024,
Volume and Issue:
184, P. 313 - 322
Published: June 17, 2024
Antimicrobial
phototherapy
has
gained
recognition
as
a
promising
approach
for
addressing
bacterial
biofilms,
however,
its
effectiveness
is
often
impeded
by
the
robust
physical
and
chemical
defenses
of
biofilms.
Traditional
antibacterial
nanoplatforms
face
challenges
in
breaching
extracellular
polymeric
substances
barrier
to
efficiently
deliver
photosensitizers
deep
into
Moreover,
prevalent
hypoxia
within
biofilms
restricts
success
oxygen-reliant
phototherapy.
In
this
study,
we
engineered
soft
mesoporous
organosilica
nanoplatform
(SMONs)
incorporating
polyethylene
glycol
(PEG),
catalase
(CAT),
indocyanine
green
(ICG),
forming
SMONs-PEG-CAT-ICG
(SPCI).
We
compared
antimicrobial
efficacy
SPCI
with
more
rigid
nanoplatforms.
Our
results
demonstrated
that
unique
flexible
mechanical
properties
enable
it
navigate
through
biofilm
barriers,
markedly
enhancing
ICG
penetration
methicillin-resistant
Staphylococcus
aureus
(MRSA)
Notably,
murine
subcutaneous
MRSA
infection
model,
showed
superior
pharmacokinetic
benefits
over
counterparts.
The
embedded
effectively
converts
excess
H
