Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 30, 2025
During
the
treatment
of
solid
tumors,
local
therapeutic
approaches
carry
risk
incomplete
radical
cure,
which
may
lead
to
rapid
tumor
growth.
Incomplete
microwave
ablation
(iMWA)
can
induce
tumors
exhibit
highly
invasive
and
uncontrollable
growth,
is
related
immunosuppressive
microenvironment.
A
multifunctional
bimetallic
Ca/Zn
nanoagonist
(PZH/Zn@CaNA)
with
a
biomimetic
liposome-modified
surface
tissues
after
iMWA
developed.
In
response
acidic
microenvironment,
released
traditional
Chinese
medicine
preparation
Pien
Tze
Huang
(PZH)
reduced
protein
expressions
JAK2-STAT3
signaling
pathway,
thereby
slowing
down
proliferation
growth
hepatocellular
carcinoma
(HCC).
Furthermore,
ions
Ca2⁺
Zn2⁺
cascade
enhance
killing
effect
oxidative
stress,
generating
substantial
amounts
reactive
oxygen
species.
This
process
induces
pyroptosis
releases
significant
quantities
damage
associated
molecular
patterns,
triggering
immune
activation
mechanisms
STING
pathway
that
reshape
HCC
microenvironment
resulting
from
iMWA.
strategy
markedly
differs
previous
chemoimmunotherapies,
not
only
effectively
addressed
problem
conventional
drugs
showing
heterogeneous
distribution
in
regions,
but
also
verified
critical
role
played
by
PZH/Zn@CaNA
inhibiting
iMWA-induced
regulating
stress
remodeling
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(30)
Published: Sept. 8, 2023
Radiotherapy
(RT),
a
widely
used
clinical
treatment
modality
for
cancer,
uses
high-energy
irradiation
reactive
oxygen
species
(ROS)
production
and
DNA
damage.
However,
its
therapeutic
effect
is
primarily
limited
owing
to
insufficient
damage
tumors
harmful
effects
on
normal
tissues.
Herein,
core-shell
structure
of
metal-semiconductors
(Au@AgBiS2
nanoparticles)
that
can
function
as
pyroptosis
inducers
both
kill
cancer
cells
directly
trigger
robust
anti-tumor
immune
against
4T1
triple-negative
murine
breast
metastasis
rationally
designed.
Metal-semiconductor
composites
enhance
the
generation
considerable
ROS
simultaneously
RT
sensitization.
Moreover,
Au@AgBiS2
,
inducer,
induces
caspase-3
protein
activation,
gasdermin
E
cleavage,
release
damage-associated
molecular
patterns.
In
vivo
studies
in
BALB/c
mice
reveal
nanoparticles
combined
with
exhibit
remarkable
antitumor
activity,
preventing
tumor
growth,
lung
metastasis.
Therefore,
this
an
alternative
designing
highly
effective
radiosensitizers
radioimmunotherapy.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(2), P. 1582 - 1598
Published: Jan. 3, 2024
Heterogeneity
of
the
tumor
microenvironment
(TME)
is
primarily
responsible
for
ineffective
treatment
and
uncontrolled
progression.
Pyroptosis-based
immunogenic
cell
death
(ICD)
therapy
an
ideal
strategy
to
overcome
TME
heterogeneity
obtain
a
satisfactory
antitumor
effect.
However,
efficiency
current
pyroptosis
therapeutics,
which
mainly
depends
on
single
endogenous
or
exogenous
stimulus,
limited
by
intrinsic
pathological
features
malignant
cells.
Thus,
it
necessary
develop
synergistic
with
high
specificity
modulability.
Herein,
nanoplatform
constructed
combining
neutrophil
camouflaging
shell
self-synergistic
reactive
oxygen
species
(ROS)
supplier-loaded
polymer.
The
covered
membranes
endow
stealthy
properties
facilitate
sufficient
accumulation.
Under
laser
irradiation,
photosensitizer
(indocyanine
green)
exogenously
triggers
ROS
generation
converts
irradiation
into
heat
upregulate
NAD(P)H:quinone
oxidoreductase
1,
further
catalyzes
β-Lapachone
self-produce
ROS,
resulting
in
amplified
ICD
outcomes.
results
confirm
that
continuously
production
not
only
eliminates
primary
but
also
concurrently
enhances
gasdermin
E-mediated
pyroptosis,
initiates
cascade,
re-educates
heterogeneous
TME,
promotes
systemic
immune
response
suppress
distant
tumors.
Overall,
this
provides
efficient
durable
method
redesigning
system
targeted
inhibition.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(22), P. 12387 - 12387
Published: Nov. 18, 2024
Cancer
is
a
multifaceted
disease
influenced
by
various
mechanisms,
including
the
generation
of
reactive
oxygen
species
(ROS),
which
have
paradoxical
role
in
both
promoting
cancer
progression
and
serving
as
targets
for
therapeutic
interventions.
At
low
concentrations,
ROS
serve
signaling
agents
that
enhance
cell
proliferation,
migration,
resistance
to
drugs.
However,
at
elevated
levels,
induce
oxidative
stress,
causing
damage
biomolecules
leading
death.
cells
developed
mechanisms
manage
activating
pathways
such
NRF2,
NF-κB,
PI3K/Akt.
This
review
explores
relationship
between
cancer,
focusing
on
death
like
apoptosis,
ferroptosis,
autophagy,
highlighting
potential
strategies
exploit
target
cells.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(29)
Published: June 3, 2024
Abstract
Exploring
efficient
and
low‐toxicity
radiosensitizers
to
break
through
the
bottleneck
of
radiation
tolerance,
immunosuppression
poor
prognosis
remains
one
critical
developmental
challenges
in
radiotherapy.
Nanoheterojunctions,
due
their
unique
physicochemical
properties,
have
demonstrated
excellent
radiosensitization
effects
energy
deposition
lifting
tumor
radiotherapy
inhibition.
Herein,
they
doped
selenium
(Se)
into
prussian
blue
(PB)
construct
a
nano‐heterojunction
(Se@PB),
which
could
promote
increase
Fe
2+
/Fe
3+
ratio
conversion
Se
high
valence
state
with
introduction.
The
‐Se‐Fe
electron
transfer
chain
accelerates
rate
on
surface
nanoparticles,
turn
endows
it
X‐ray
transport
capability,
enhances
physical
sensitivity.
Furthermore,
Se@PB
induces
glutathione
(GSH)
depletion
accumulation
pro‐Fenton
reaction,
thereby
disturbs
redox
balance
cells
biochemical
sensitivity
As
an
radiosensitizer,
effectively
induced
mitochondrial
dysfunction
DNA
damage,
promotes
cell
apoptosis
synergistic
cervical
cancer
This
study
elucidates
mechanism
Se‐doped
nanoheterojunction
from
perspective
biochemistry
provides
low‐toxic
strategy
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 2, 2025
Radiotherapy
is
crucial
in
local
cancer
management
and
needs
advancements.
Tumor
cells
elevate
intracellular
copper
levels
to
promote
growth
resist
radiation;
thus,
targeted
delivery
mitochondria
could
enhance
radiotherapy
by
inducing
cuproptosis
tumor
cells.
In
this
study,
we
engineered
a
multifunctional
nanoliposome
complex,
termed
Lipo-Ele@CuO2,
which
encapsulates
both
peroxide
(CuO2)
the
chelator
elesclomol,
can
Cu
ions
mitochondria.
The
Lipo-Ele@CuO2
complex
induces
mitochondria-mediated
synergistically
enhances
efficacy
of
radiotherapy.
CuO2
acts
as
donor
exhibits
inherent
sensitivity
acidic
environments.
Additionally,
it
depletes
glutathione,
thereby
sensitizing
cuproptosis.
Leveraging
its
pH-responsive
properties
microenvironment,
facilitate
controlled
release
efficiently
delivering
at
sites.
combined
vitro
vivo
studies
demonstrate
that
Lipo-Ele@CuO2-based
therapy
significantly
improves
antitumor
excellent
safety
profiles,
effectively
boosting
effectiveness
Furthermore,
metabolomic
transcriptomic
analyses
reveal
combination
precipitates
significant
alterations
energy
metabolism,
notably
repressing
genes
related
iron-sulfur
cluster
assembly
glycolysis,
confirming
induction
This
therapeutic
strategy
provides
viable
approach
for
addressing
clinical
resistance
demonstrates
translational
potential.
