An Electron Donor–Acceptor Structured Rhenium(I) Complex Photo‐Sensitizer Evokes Mutually Reinforcing "Closed‐Loop" Ferroptosis and Immunotherapy

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(17)

Published: April 10, 2024

The hypoxic microenvironment of solid tumors severely lowers the efficacy oxygen-dependent photodynamic therapy (PDT). development hypoxia-tolerant photosensitizers for PDT is an urgent requirement. In this study, a novel rhenium complex (Re-TTPY) to develop "closed-loop" based on PDT-induced ferroptosis and immune reported. Due its electron donor-acceptor (D-A) structure, Re-TTPY undergoes energy transfer processes under 550 nm light irradiation displays type I/II combined capability, which can generate

Language: Английский

---

A type I and type II chemical biology toolbox to overcome the hypoxic tumour microenvironment for photodynamic therapy

Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(11), P. 2831 - 2840

Published: Jan. 1, 2024

A chemicobiology toolbox for type I and II photodynamic therapy.

Language: Английский

---

Anthraquinone-Centered Type I Photosensitizer with Aggregation-Induced Emission Characteristics for Tumor-Targeted Two-Photon Photodynamic Therapy

ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(6), P. 2174 - 2185

Published: May 6, 2024

Exploring advanced photodynamic strategies to surmount the firm reliance on oxygen and limited penetration depth of excitation light is great significance in tumor therapy. Herein, a two-photon excitable type I photosensitizer with aggregation-induced emission characteristics, namely tBuT2AQ, rationally designed by simply equipping an anthraquinone (AQ) acceptor rotor-type electron-donating triphenylamine derivatives. The AQ moiety good electron-withdrawing ability significant spin–orbit coupling effect could facilitate generation triplet excitons triggering multichannel intersystem crossing. These further undergo electron transfer processes enable massive production reactive species because redox cycling behaviors mediated carbonyl groups moiety. Moreover, planar structure beneficial for allows deep into biological tissues. After being formulated nanoparticles acid-responsive charge-reversible polymers, tBuT2AQ can be accumulated at sites efficiently performs highly effective treatment.

Language: Английский

---

MXene‐Mediated Catalytic Redox Reactions for Biomedical Applications

ChemPlusChem, Journal Year: 2024, Volume and Issue: 89(6)

Published: Feb. 15, 2024

Reactive oxygen species (ROS) play a crucial role in orchestrating myriad of physiological processes within living systems. With the advent materdicine, an array nanomaterials has been intricately engineered to influence redox equilibrium biological milieus, thereby pioneering distinctive therapeutic paradigm predicated on ROS-centric biochemistry. Among these, two-dimensional carbides, nitrides, and carbonitrides, collectively known as MXenes, stand out due their multi-valent multi-elemental compositions, large surface area, high conductivity, pronounced local plasmon resonance effects, positioning them prominent contributors ROS modulation. This review aims provide overview advancements harnessing MXenes for catalytic reactions various applications, including tumor, anti-infective, anti-inflammatory therapies. The emphasis lies elucidating mechanism involving both pro-oxidation anti-oxidation processes, underscoring redox-related applications facilitated by self-catalysis, photo-excitation, sono-excitation properties MXenes. Furthermore, this highlights existing challenges outlines future development trends leveraging ROS-involving disease treatments, marking significant step towards integration these into clinical practice.

Language: Английский

---

Recent Advances in Photosensitizer Materials for Light‐Mediated Tumor Therapy

Chemistry - An Asian Journal, Journal Year: 2024, Volume and Issue: 19(11)

Published: April 5, 2024

Abstract Photodynamic therapy (PDT) as an emerging therapeutic method has drawn much attention in the treatment field for cancer. Photosensitizer, which can convert photon energy into cytotoxic species under light irradiation, is core component PDT. The design of photosensitizers still faces problems absorption, targeting, penetration and oxygen dependence. With rapid progress material science, various have been developed to produce tumor with high selectivity, safety, noninvasiveness. Besides, applications expanded diverse cancer treatments such drug release, optogenetics immune checkpoint blockade. In this review, we summarize recent advances methods Prevailing challenges further prospects associated are also discussed.

Language: Английский

---

High Quantum Yields Enhancement Induced by Processable AIEgens Doped Photonic Crystal Powders for Bright Luminescence and Structural Colors

Laser & Photonics Review, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Abstract The composite solid‐state structure of photonic crystals (PCs) and aggregation‐induced‐emission agents (AIEgens) exhibits potential for various applications, owing to its remarkable anti‐aggregation quenching effect exceptional fluorescence tuning ability. Herein, TVP molecules integrate into PCs by one‐step co‐assembly PMMA colloidal spheres. By carefully optimizing the assembly conditions, a kind AIEgens doped structures fabricate, which exhibit vibrant structural color, bright fluorescence, especially impressive luminescence quantum yield up 0.838. Importantly, after being grounded micron‐scale PC powders, retain their good optical properties light thermal stability. Compared with polymer film or deposited films on substrates previously reported AIEgens, powder state endows them processibility, enabling be seamlessly polymers meet diverse requirements different processing techniques. processability facilitates production 2D 3D models that possess both vivid color luminescence. Moreover, strategy fabricating powders can employed spheres varying diameters thereby generation adjustable thus substantially broadening application scenarios.

Language: Английский

---

Recent Progress in Radiosensitive Nanomaterials for Radiotherapy-Triggered Drug Release

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Benefiting from the unique properties of ionizing radiation, such as high tissue penetration, spatiotemporal resolution, and clinical relevance compared with other external stimuli, radiotherapy-induced drug release strategies are showing great promise in developing effective personalized cancer treatments. However, requirement doses X-ray irradiation to break chemical bonds for limits application prodrug activation clinics. Recent advances nanomaterials offer a promising approach radiotherapy sensitization well integrating multiple modalities improved therapy outcomes. In particular, catalytic radiosensitization that utilizes electrons energy generated by upon has demonstrated excellent potential enhanced radiotherapy. this Review, we summarize design principles X-ray-responsive controlled release, radiosensitization, recent progress nanoradiosensitizers integration chemotherapy, chemodynamic therapy, photodynamic photothermal gas immunotherapy. Finally, discuss challenges heading toward possible translation. We expect emerging based on radiotherapy-triggered will facilitate frontier accurate near future.

Language: Английский

---

Nonlight-Driven Aggregation-Induced Emission Luminogens for Bioimaging and Theranostics

Chemical & Biomedical Imaging, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Aggregation-induced emission luminogens (AIEgens) have been prosperously developed and applied in the fields of optical imaging theranostics since its establishment. Nowadays, AIEgens can fulfill nearly all requirements with spectra ranging from visible to near-infrared wavelengths. Although a variety varying wavelengths functionalities continuously designed, their performance is heavily dependent on use conventional light sources, such as xenon lamps lasers, which severely hinder further applications due limited penetration depth background autofluorescence biological tissues. To mitigate these limitations maximize potential AIEgens, unconventional excitation sources chemical energy, ultrasound, X-ray offer effective alternatives that circumvent drawbacks associated traditional light-based constant excitation. In this Review, we introduce fundamental principles governing combination highlight recent advancements using excited by for bioimaging theranostics, discuss current challenges future perspectives aimed at advancing biomedical AIEgens.

Language: Английский

---

Organic Ionic Host–Guest Phosphor with Dual-Confined Nonradiation for Constructing Ultrahigh-Temperature X-ray Scintillator

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Scintillators with X-ray-excitable luminescence have attracted great attention in the fields of medical radiography, nondestructive inspection, and high-energy physics. However, thermal quenching significantly reduces radioluminescence efficiency, particularly for those phosphorescent scintillators promising radiation-induced triplet exciton utilization, ultimately limiting their applications high-temperature scenarios. Herein, we develop ultrahigh-temperature based on organic ionic host–guest phosphorescence systems unprecedented thermal-stable emissions up to 673 K. The guest phosphor features spin-vibronic coupling-assisted intersystem crossing, effectively transforming thermally activated delayed fluorescence overcoming inactivation excitons. Meanwhile, rigid host robust electrostatic interactions minimize both intrinsic extrinsic nonradiations excitons, so-called dual-confined nonradiation. These two mechanisms work synergistically, contributing highly efficient exciton-based a room-temperature efficiency 38.7% ultrahigh-temperature-resistant dual emissions. Such an innovative scintillator achieves impressively low X-ray detection limit 71.5 nGy s–1 remarkably bright photoluminescence (efficiency 80.4% at 483 K), enabling imaging.

Language: Английский

---

Two-coordinate copper(I) complexes enable efficient X-ray scintillation and imaging

Science China Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Language: Английский

---