Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: April 18, 2024
Degenerative
orthopaedic
diseases
pose
a
notable
worldwide
public
health
issue
attributable
to
the
global
aging
population.
Conventional
medical
approaches,
encompassing
physical
therapy,
pharmaceutical
interventions,
and
surgical
methods,
face
obstacles
in
halting
or
reversing
degenerative
process.
In
recent
times,
exosome-based
therapy
has
gained
widespread
acceptance
popularity
as
an
effective
treatment
for
diseases.
This
therapeutic
approach
holds
potential
"cell-free"
tissue
regeneration.
Exosomes,
membranous
vesicles
resulting
from
fusion
of
intracellular
multivesicles
with
cell
membrane,
are
released
into
extracellular
matrix.
Addressing
challenges
such
rapid
elimination
natural
exosomes
vivo
limitation
drug
concentration
can
be
effectively
achieved
through
various
strategies,
including
engineering
modification,
gene
overexpression
biomaterial
binding.
review
provides
concise
overview
source,
classification,
preparation
methods
exosomes,
followed
by
in-depth
analysis
their
functions
applications.
Furthermore,
explores
strategies
utilizing
diseases,
overexpression,
The
primary
objective
is
provide
fresh
viewpoint
on
utilization
addressing
bone
conditions
support
practical
application
theranosis
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(19)
Published: March 1, 2024
Abstract
Exosomes,
nanoparticles
secreted
by
various
cells,
composed
of
a
bilayer
lipid
membrane,
and
containing
bioactive
substances
such
as
proteins,
nucleic
acids,
metabolites,
etc.,
have
been
intensively
investigated
in
tissue
engineering
owing
to
their
high
biocompatibility
versatile
biofunction.
However,
there
is
still
lack
high‐quality
review
on
bone
defect
regeneration
potentiated
exosomes.
In
this
review,
the
biogenesis
isolation
methods
exosomes
are
first
introduced.
More
importantly,
engineered
current
state
knowledge
discussed
review.
Afterward,
biomaterial
carriers
mechanisms
repair
elucidated
compelling
evidence
presented.
Thus,
future
perspectives
concerns
revealed
help
devise
advanced
modalities
based
overcome
challenges
regeneration.
It
totally
believed
will
attract
special
attention
from
clinicians
provide
promising
ideas
for
works.
Nano-Micro Letters,
Journal Year:
2024,
Volume and Issue:
17(1)
Published: Sept. 29, 2024
Abstract
Hydrogel
scaffolds
have
numerous
potential
applications
in
the
tissue
engineering
field.
However,
tough
hydrogel
implanted
vivo
are
seldom
reported
because
it
is
difficult
to
balance
biocompatibility
and
high
mechanical
properties.
Inspired
by
Chinese
ramen,
we
propose
a
universal
fabricating
method
(printing-P,
training-T,
cross-linking-C,
PTC
&
PCT)
for
fill
this
gap.
First,
3D
printing
fabricates
scaffold
with
desired
structures
(P).
Then,
could
extraordinarily
properties
functional
surface
structure
cycle
training
salting-out
assistance
(T).
Finally,
results
fixed
photo-cross-linking
processing
(C).
The
gelatin
exhibit
excellent
tensile
strength
of
6.66
MPa
(622-fold
untreated)
biocompatibility.
Furthermore,
possesses
from
nanometer
micron
millimeter,
which
can
efficiently
induce
directional
cell
growth.
Interestingly,
strategy
produce
bionic
human
10
kPa-10
changing
type
salt,
many
hydrogels,
such
as
silk,
be
improved
or
PCT
strategies.
Animal
experiments
show
that
effectively
promote
new
generation
muscle
fibers,
blood
vessels,
nerves
within
4
weeks,
prompting
rapid
regeneration
large-volume
loss
injuries.
Gels,
Journal Year:
2024,
Volume and Issue:
10(4), P. 220 - 220
Published: March 25, 2024
This
study
explores
the
dynamic
field
of
3D-printed
hydrogels,
emphasizing
advancements
and
challenges
in
customization,
fabrication,
functionalization
for
applications
biomedical
engineering,
soft
robotics,
tissue
engineering.
It
delves
into
significance
tailored
scaffolds
regeneration,
enhancement
bioinks
realistic
replication,
development
bioinspired
actuators.
Additionally,
this
paper
addresses
fabrication
issues
aiming
to
mimic
biological
structures
through
high-resolution,
multimaterial
printing.
In
it
highlights
efforts
create
environments
conducive
cell
migration
functional
development.
research
also
extends
drug
delivery
systems,
focusing
on
controlled
release
biocompatibility,
examines
integration
hydrogels
with
electronic
components
bioelectronic
applications.
The
interdisciplinary
nature
these
a
commitment
overcoming
material
limitations
optimizing
techniques
realize
full
potential
improving
health
well-being.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: April 18, 2024
Degenerative
orthopaedic
diseases
pose
a
notable
worldwide
public
health
issue
attributable
to
the
global
aging
population.
Conventional
medical
approaches,
encompassing
physical
therapy,
pharmaceutical
interventions,
and
surgical
methods,
face
obstacles
in
halting
or
reversing
degenerative
process.
In
recent
times,
exosome-based
therapy
has
gained
widespread
acceptance
popularity
as
an
effective
treatment
for
diseases.
This
therapeutic
approach
holds
potential
"cell-free"
tissue
regeneration.
Exosomes,
membranous
vesicles
resulting
from
fusion
of
intracellular
multivesicles
with
cell
membrane,
are
released
into
extracellular
matrix.
Addressing
challenges
such
rapid
elimination
natural
exosomes
vivo
limitation
drug
concentration
can
be
effectively
achieved
through
various
strategies,
including
engineering
modification,
gene
overexpression
biomaterial
binding.
review
provides
concise
overview
source,
classification,
preparation
methods
exosomes,
followed
by
in-depth
analysis
their
functions
applications.
Furthermore,
explores
strategies
utilizing
diseases,
overexpression,
The
primary
objective
is
provide
fresh
viewpoint
on
utilization
addressing
bone
conditions
support
practical
application
theranosis
