Low‐Intensity Focused Ultrasound‐Responsive Nanobubbles Enhance Thrombus Targeting and Penetration for Highly Effective Thrombolytic Therapy DOI Creative Commons
Wenli Zhang, Maoyuan Sun,

Lian Xu

et al.

Small Structures, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 6, 2024

Owing to the short half‐life, restricted targeting capability, and high bleeding risk associated with thrombolytic drugs, safe effective therapy remains challenging. Based on natural immune escape functions of platelets during thrombosis, spatiotemporally controlled nanobubbles (PAF@M) are developed specifically target thrombus sites. These designed by loading an air core perfluoropentane (PFP) l ‐arginine within a poly(lactic ‐co ‐glycolic acid) shell coating it platelet membrane. Under stimulation low‐intensity focused ultrasound (LIFU), physical shear stress promotes deep penetration into thrombus. Moreover, liquid–gas phase transition PFP release nitric oxide synergistically enhance ultrasonic cavitation disrupt structure. In terms mechanism, these gas molecules induce acoustic pore action fibrin network structure, loosening interior thrombus, act surfaces red blood cells activated platelets, launching comprehensive attack It is believed that PAF@M will delay progression thrombosis achieve highly therapy. This simple LIFU response principle has potential be safer more alternative current pharmaceutical approaches.

Language: Английский

Hydrogen therapy: recent advances and emerging materials DOI
Zheng Jiang, Mailudan Ainiwaer, Jun Liu

et al.

Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(16), P. 4136 - 4154

Published: Jan. 1, 2024

Hydrogen therapy, leveraging its selective attenuation of hydroxyl radicals (˙OH) and ONOO

Language: Английский

Citations

5
Nanomedicines for cardiovascular diseases: lessons learned and pathways forward DOI
Yufei Mao,

X.F. Shi,

Patricia Sun

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123271 - 123271

Published: March 1, 2025

Language: Английский

Citations

0
Metal coordination-based double-network microsphere scaffolds facilitate bone regeneration via oxygen-driven mitochondrial oxidative phosphorylation DOI
Chao Lin, Jialei He, Jiachen Li

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162233 - 162233

Published: April 1, 2025

Language: Английский

Citations

0
Molecular Hydrogen Therapy: Mechanisms, Delivery Methods, Preventive, and Therapeutic Application DOI Creative Commons
Jiayi Jin,

Lijun Yue,

Maoru Du

et al.

MedComm, Journal Year: 2025, Volume and Issue: 6(5)

Published: April 28, 2025

ABSTRACT Molecular hydrogen (H 2 ), recognized as the smallest gas molecule, is capable of permeating cellular membranes and diffusing throughout body. Due to its high bioavailability, H considered a therapeutic for treatment various diseases. The efficacy contingent upon factors such administration method, duration contact with diseased tissue, concentration at targeted sites. can be administered exogenously also produced endogenously within intestinal tract. A comprehensive understanding delivery mechanisms modes action crucial advancing medicine. This review highlights H₂’s action, summarizes methods, explores advancements in treating diseases (e.g., inflammatory bowel disease, ischemia–reperfusion, colorectal cancer). Additionally, applications managing other are discussed. Finally, challenges associated clinical application potential solutions explored. We propose that current faced by effectively addressed through use nanoplatforms; furthermore, interactions between gut microbiota may provide insights into Future research should explore synergistic effects conjunction conventional therapies develop personalized plans achieve precision

Language: Английский

Citations

0
Controlled Release of Hydrogen‐Carrying Perfluorocarbons for Ischemia Myocardium‐Targeting 19F MRI‐Guided Reperfusion Injury Therapy DOI Creative Commons
Chaoqun Nie,

A Rong,

Jing Wang

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(29)

Published: Aug. 18, 2023

Abstract Hydrogen gas is recently proven to have anti‐oxidative and anti‐inflammation effects on ischemia‐reperfusion injury. However, the efficacy of hydrogen therapy limited by efficiency storage, targeted delivery, controlled release. In this study, H 2 ‐PFOB nanoemulsions (NEs) developed with high loading capacity for ischemic myocardium precision therapy. The hydrogen‐carrying NEs determined chromatography microelectrode methods. Positive uptake in influence 19 F‐MR signal are quantitatively visualized using a 9.4T MR imaging system. biological therapeutic examined myocardial injury mouse model. results illustrated that can efficaciously achieve specific infiltration into exhibit excellent antioxidant anti‐inflammatory properties injury, which be dynamically Moreover, burst release induced low‐intensity focused ultrasound (LIFU) irradiation further promotes effect favorable biosafety profile. potential fully unfolded, may hold great future hydrogen‐based applications tailored

Language: Английский

Citations

7
Optical Fiber‐Enabled In Situ Photocatalytic Hydrogen Generation for Infiltrating Tumor Therapy in Brain DOI
Hang Zhang,

Shujuan Guan,

Lei Wang

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(28)

Published: June 17, 2024

In addition to repressing proliferation, inhibiting the infiltration of tumor cells is an important strategy improve treatment malignant tumors. Herein, a photocatalyst (pCNMC@Pt) designed by sequentially assembling manganese dioxide, chlorin e6, and platinum (Pt) nanoparticles onto protonated graphitic carbon nitride. With help Z-scheme structure near-infrared (NIR) photosensitizer, pCNMC@Pt capable responding NIR light generate large amounts hydrogen (H

Language: Английский

Citations

0
Low‐Intensity Focused Ultrasound‐Responsive Nanobubbles Enhance Thrombus Targeting and Penetration for Highly Effective Thrombolytic Therapy DOI Creative Commons
Wenli Zhang, Maoyuan Sun,

Lian Xu

et al.

Small Structures, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 6, 2024

Owing to the short half‐life, restricted targeting capability, and high bleeding risk associated with thrombolytic drugs, safe effective therapy remains challenging. Based on natural immune escape functions of platelets during thrombosis, spatiotemporally controlled nanobubbles (PAF@M) are developed specifically target thrombus sites. These designed by loading an air core perfluoropentane (PFP) l ‐arginine within a poly(lactic ‐co ‐glycolic acid) shell coating it platelet membrane. Under stimulation low‐intensity focused ultrasound (LIFU), physical shear stress promotes deep penetration into thrombus. Moreover, liquid–gas phase transition PFP release nitric oxide synergistically enhance ultrasonic cavitation disrupt structure. In terms mechanism, these gas molecules induce acoustic pore action fibrin network structure, loosening interior thrombus, act surfaces red blood cells activated platelets, launching comprehensive attack It is believed that PAF@M will delay progression thrombosis achieve highly therapy. This simple LIFU response principle has potential be safer more alternative current pharmaceutical approaches.

Language: Английский

Citations

0