Expert Opinion on Drug Delivery,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 17, 2024
Introduction
Chiral
nanocarriers
enhance
therapeutic
efficacy
by
improving
in
vivo
stability
and
cellular
uptake.
Chemical
functionalization
reduces
cytotoxicity,
resulting
favorable
biocompatibility.
Nanoparticles
self-assemble
into
supraparticles,
enhancing
drug
delivery
through
improved
retention
loading.
Area
covered
This
review
covers
chiral
nanostructures
their
mechanisms,
applications
various
healthcare
applications.
Expert
Opinion
The
chirality
of
biomaterials
is
crucial
for
advancing
nanomedicine.
nanosystem
interacting
selectively
with
biological
molecules,
specificity
efficacy.
off-target
effects
improves
outcomes.
Research
has
focused
on
uptake
elimination
to
ensure
safety,
nanomaterials
also
show
promise
optical
sensing
gene
editing.
Their
biocompatibility
ability
supraparticles
may
make
them
ideal
systems.
Nanoscale,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
This
review
covers
fundamental
principles
and
techniques
for
measuring
chiral
properties
as
well
the
synthesis
of
sulfur-based
nanomaterials,
their
optical
chiroptical
properties,
possible
applications.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(28), P. 37308 - 37317
Published: July 8, 2024
The
chiroptical
activity
of
various
semiconductor
inorganic
nanocrystalline
materials
has
typically
been
tested
using
circular
dichroism
or
circularly
polarized
luminescence.
Herein,
we
report
on
a
high-throughput
screening
method
for
identifying
and
differentiating
chiroptically
active
quantum-sized
ZnO
crystals
Raman
spectroscopy
combined
with
principal
component
analysis.
quantum
dots
(QDs)
coated
by
structurally
diverse
homo-
heterochiral
aminoalcoholate
ligands
(cis-
trans-1-amino-2-indanolate,
2-amino-1-phenylethanolate,
diphenyl-2-pyrrolidinemethanolate)
were
prepared
the
one-pot
self-supporting
organometallic
procedure
then
extensively
studied
toward
identification
specific
fingerprints
spectral
variations.
direct
comparison
between
spectra
demonstrates
that
it
is
very
difficult
to
make
definite
recognition
QDs
enantiomers
based
only
differences
in
respective
bands'
position
shifts
their
intensities.
However,
applied
approach
involving
analysis
performed
allows
simultaneous
differentiation
QDs.
first
second
components
explain
98,
97,
87%
variability
among
families
demonstrate
possibility
presented
as
qualitative
assay.
Thus,
reported
multivariate
paves
way
chirotopically
nanocrystals.
Advanced Optical Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 14, 2024
Abstract
Chiral
carbon
dots
(CDs)
with
circularly
polarized
luminescence
(CPL)
are
one
of
the
most
dynamic
areas
modern
science.
However,
design,
preparation,
and
ambiguity
mechanism
solid‐state
CPL‐active
CDs
remains
a
formidable
challenge.
Herein,
for
first
time,
customized
chiroptical
activities
in
solid
state,
especially
CPL,
transcribed
from
chiral
metal–organic
framework
(CMOFs)
via
bottle‐around‐ship
strategy.
Within
these
CMOFs⊃CDs
assemblies,
inherited
chirality
host
CMOFs
through
host–guest
interactions,
which
is
revealed
by
density
functional
theory
(DFT)
simulations
experimental
results,
amplified
dissymmetry
factor
(
g
lum
)
effective
artificial
light‐harvesting
systems.
Impressively,
pairs
generated
color‐tunable
CPL
white
chromaticity
coordinates
(0.32,
0.32).
Furthermore,
benefiting
excellent
processability,
as
luminescent
coatings
3D
printing
inks,
light‐emitting
diode,
an
extended
model
“light
bulb”
featuring
successfully
fabricated,
respectively.
This
strategy
paves
new
avenue
synthesis
advanced
application
CDs‐based
materials.
Expert Opinion on Drug Delivery,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 17, 2024
Introduction
Chiral
nanocarriers
enhance
therapeutic
efficacy
by
improving
in
vivo
stability
and
cellular
uptake.
Chemical
functionalization
reduces
cytotoxicity,
resulting
favorable
biocompatibility.
Nanoparticles
self-assemble
into
supraparticles,
enhancing
drug
delivery
through
improved
retention
loading.
Area
covered
This
review
covers
chiral
nanostructures
their
mechanisms,
applications
various
healthcare
applications.
Expert
Opinion
The
chirality
of
biomaterials
is
crucial
for
advancing
nanomedicine.
nanosystem
interacting
selectively
with
biological
molecules,
specificity
efficacy.
off-target
effects
improves
outcomes.
Research
has
focused
on
uptake
elimination
to
ensure
safety,
nanomaterials
also
show
promise
optical
sensing
gene
editing.
Their
biocompatibility
ability
supraparticles
may
make
them
ideal
systems.
