Cardiovascular Drugs and Therapy, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 6, 2024
Language: Английский
Advanced Science, Journal Year: 2024, Volume and Issue: 11(25)
Published: April 26, 2024
Abstract Myocardial infarction (MI), a consequence of coronary artery occlusion, triggers the degradation ferritin, resulting in elevated levels free iron heart and thereby inducing ferroptosis. Targeting myocardial ferroptosis through chelation excess has therapeutic potential for MI treatment. However, post ischemic injury areas using conventional iron‐specific chelators is hindered by ineffective intracellular chelation, rapid clearance, high systemic toxicity. A chitosan‐desferrioxamine nanosponge (CDNS) designed co‐crosslinking chitosan deferoxamine noncovalent gelation to address these challenges. This architecture facilitates direct regardless (DFO) release due its sponge‐like porous hydrogel structure. Upon cellular internalization, CDNS can effectively chelate facilitate efflux captured iron, inhibiting associated oxidative stress lipid peroxidation. In mouse models, injection promotes sustainable retention suppression infarcted heart. intervention improves cardiac function alleviates adverse remodeling post‐MI, leading decreased promotion angiogenesis inhibition study reveals nanosponge‐based nanomedicine targeting with efficient efflux, offering promising
Language: Английский
Citations
16
APOPTOSIS, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 20, 2025
Language: Английский
Citations
1
Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)
Published: Feb. 17, 2025
Language: Английский
Citations
1
Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 25, 2025
Language: Английский
Citations
1
International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 2461 - 2473
Published: Feb. 1, 2025
Ferroptosis is a type of iron-dependent programmed cell death characterized by depletion glutathione. Although generally less harmful to normal cells, in tumor the high demand for iron ions provides conditions conducive ferroptosis. In this review, we provide an overview recent progress research on regulation ferroptosis summarizing and assessing current state, trends, applications nanomaterials cells. Given advantages terms targeting, safety, improved drug efficacy, reduced side effects, these materials are considered have potential therapeutic value modulating cells via different mechanisms. respect, describe methods modifying interfering with glutathione activity lipid peroxidation. The development that can be applied induce or inhibit anticipated new options treatment diverse range diseases.
Language: Английский
Citations
1
Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(9), P. 4386 - 4405
Published: July 8, 2024
Ferroptosis is a form of iron-dependent regulatory cell death that related to the pathogenesis and progression various cardiovascular diseases, such as arrhythmia, diabetic cardiomyopathy, myocardial infarction, ischemia/reperfusion injury, heart failure. This makes it promising therapeutic target for diseases. It interesting significant number disease treatment drugs derived from phytochemicals have been shown ferroptosis, thus producing cardioprotective effects. study offers concise overview initiation control mechanisms ferroptosis. discusses core factors ferroptosis potential new targets elucidating how influences In addition, this review systematically summarizes effects on emphasizing their clinical applications in treating provides reference further molecular may accelerate application diseases worth research field.
Language: Английский
Citations
6
Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 104, P. 102629 - 102629
Published: Dec. 5, 2024
Language: Английский
Citations
6
Cardiology in Review, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 12, 2025
Coronary artery disease (CAD) is responsible for 690,000 deaths a year, leading cause of mortality worldwide. CAD results from cholesterol plaque buildup in arteries. Chelation therapy, which uses ethylenediaminetetraacetic acid to remove toxic metals the bloodstream, has been explored as an alternative treatment atherosclerotic CAD. While 2013 Trial Assess Therapy (TACT) trial showed modest cardiovascular benefits, particularly patients with diabetes, subsequent studies such TACT2 did not confirm its efficacy reducing events diabetes. Adverse effects chelation therapy could include renal dysfunction, electrolyte imbalances, and potential complications heavy metal mobilization that be fatal. Still, none these were seen TACT or TACT2.
Language: Английский
Citations
0
Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 962 - 962
Published: Feb. 19, 2025
Cardiovascular diseases (CVDs) represent a leading global health crisis, significantly impairing patients' quality of life and posing substantial risks to their survival. Conventional therapies for CVDs often grapple with challenges such as inadequate targeting precision, suboptimal therapeutic efficacy, potential adverse side effects. To address these shortcomings, researchers are intensively developing advanced drug delivery systems characterized by high specificity selectivity, excellent biodegradability, superior biocompatibility, minimal toxicity. These innovative enable the precise pharmaceuticals drug-loading capacities, leakage, expansive specific surface areas, thereby enhancing outcomes. In this review, we summarize classify various materials application values. We also evaluate feasibility efficacy viral non-viral vectors treatment CVDs, existing limitations prospects discussed. hope that review will provide new perspectives future development ultimately contributing improved patient care
Language: Английский
Citations
0
Small Science, Journal Year: 2025, Volume and Issue: 5(5)
Published: Feb. 20, 2025
Nanomaterials have been vastly used in daily life. However, owing to their unique properties, nanomaterials also show potential side effects. Among the various organs affected by nanomaterials, circulatory system stands out as particularly vulnerable, drawing additional attention its cardiac toxicity. To address cardiovascular nanotoxicity and further promote safe use of nanotechnology, a comprehensive review cardiotoxicity induced is provided. The begins identifying current research trends hotspots this field via bibliometric analysis. Subsequently, based on objectively obtained hotspots, mechanism nanotoxicity, including exposure route, membrane injury, ion disturbance, oxidative stress, inflammation, cell death, reviewed discussed. Finally, strategies for mitigation are proposed. objective assist readers understanding facilitate application human health.
Language: Английский
Citations
0