Cardiovascular Drugs and Therapy, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 6, 2024
Language: Английский
Molecular Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown
Published: May 2, 2025
Iron homeostasis imbalance, caused by conditions such as thalassemia, sickle cell anemia, and myocardial infarction, often results in elevated free iron levels, leading to ferroptosis severe organ damage. While current chelators like deferoxamine (DFO) deferiprone are effective, they associated with significant side effects, including nephrotoxicity, gastrointestinal bleeding, liver fibrosis. This creates an urgent need for safer, natural-product-based alternatives effective chelation therapy (ICT). study investigates caffeic acid (CA)-based complexes biogenic amines, specifically spermine (CA-Sp) histidine (CA-His), potential ICT candidates. Initial vitro assays on HEK-293 cells under dextran (ID)-induced toxicity have demonstrated their protective CA-Sp exhibiting superior efficacy. The vivo studies mice further validated potential, showing remarkable mitigation compared DFO. Inductively coupled plasma mass spectrometry (ICP-MS) reveals excretion fecal matter the treatment group along reductions serum ferritin levels. markers of nephrotoxicity (creatinine) function (ALT, AST) also been shown be normalized treated groups, while immunological analyses revealed restored levels neutrophils, T cells, B cells. Additionally, inflammatory cytokines, TNF-α IL-6, exhibited reductions, CA-based formulations surpassing effects Histological using Prussian blue staining confirmed reduced deposition vital organs liver, kidney, spleen. These findings highlight a particularly promising candidate ICT, offering safer more strategy managing overload its complications.
Language: Английский
Citations
0
Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12
Published: May 2, 2025
Myocardial infarction, as the principal type of ischemic heart disease, has currently become focus research on its prevention and treatment strategies. From perspective myocardial infarction pathogenesis, it is urgent to impede progression this disease improve diagnosis techniques. Ferroptosis, a form programmed cell death mechanistically distinct from apoptosis autophagy, implicated throughout pathogenesis infarction. Dysregulation protein translation leads abnormal expression, disruption cellular signaling, dysfunction, thereby disturbing normal function exacerbating progression. Consequently, clarifying mechanism dysregulation in ferroptosis during will enhance understanding In review, latest progress relationship between collected. The mechanisms by which they regulate are explored, current status role different stages introduced. These findings expected provide valuable insights for pathophysiological precise treatment.
Language: Английский
Citations
0
Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
This review constructs a dynamic and progressive pathological framework for the development of IHD, from MI to IRI eventually HF, systematically revealing multidimensional therapeutic strategies nanomaterials.
Language: Английский
Citations
0
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: May 16, 2025
Abstract Cigarette smoke (CS) disrupts mitochondrial iron homeostasis, causing excess free to generate reactive oxygen species, leading oxidative stress and impairing tissue repair. For smokers undergoing bone defect repair, achieving precise control over the balance between stored iron, while simultaneously enhancing endogenous poses a considerable challenge. This study introduces dual‐drive strategy (IBDS), which efficiently chelates promotes ferritin synthesis create FerritinBank for deposition, thus optimizing homeostasis. IBDS is delivered through an injectable, biodegradable iron‐capturing hydrogel (SilMA/gelMA/DPT). The released DPT selectively targets within mitochondria, modulating dynamics restore their function. action complemented by promotion of synthesis, serves bolster homeostasis suppress ferroptosis. Transcriptomic sequencing experimental data suggest that corrects energy metabolism abnormalities macromolecule synthesis. In vivo studies confirm significantly improves healing smoking‐induced calvarial defects. first report nanoparticles promoting build reservoir, highlighting potential regeneration in other iron‐overload‐related conditions.
Language: Английский
Citations
0
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(37), P. 48880 - 48894
Published: Sept. 3, 2024
Myocardial infarction (MI) is a serious cardiovascular disease with high morbidity and mortality rates, posing significant threat to patient's health quality of life. Following MI, the damaged myocardial tissue typically not fully repaired, leading permanent impairment function. While traditional treatments can alleviate symptoms reduce pain, their ability repair heart muscle limited. Functionalized hydrogels, broad category materials diverse functionalities, enhance properties hydrogels cater needs engineering, drug delivery, medical dressings, other applications. Recently, functionalized have emerged as promising new therapeutic approach for treatment MI. possess outstanding biocompatibility, customizable mechanical properties, drug-release capabilities. These enable them offer scaffold support, release, regeneration promotion, making treating This paper aims evaluate advancements delivery methods while also discussing potential challenges they may pose future clinical use.
Language: Английский
Citations
2
Cardiovascular Drugs and Therapy, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 6, 2024
Language: Английский
Citations
1