A Smart Nanomedicine Unleashes a Dual Assault of Glucose Starvation and Cuproptosis to Supercharge αPD‐L1 Therapy DOI Creative Commons

Yiming Xu,

Yuan Wu,

Xinjie Zheng

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Combination therapy has become a promising strategy for promoting the outcomes of anti-programmed death ligand-1 (αPD-L1) in lung cancer. Among all, emerging strategies targeting cancer metabolism have shown great potency treating cancers with immunotherapy. Here, alteration glucose and copper metabolisms is found to synergistically regulate PD-L1 expression cells. Thus, an intelligent biomimetic nano-delivery system synthesized by camouflaging cell membranes onto oxidase-loaded Cu-LDHs (CMGCL) targeted interference. Such novel nanomedicine able induce cuproptosis upregulation significantly via self-amplified cascade reactions. Meanwhile, decent membrane coating, CMGCL exhibited biosafety, tumor-targeted efficiency anti-tumor effects LLC tumor-bearing mice models. Additionally, combination can sensitize therapeutic αPD-L1, substantially tumor inhibition both subcutaneous metastasis LLC-bearing Overall, these findings highlight potential connections between cuproptosis, offering approach integrating starvation,

Language: Английский

Layered Double Hydroxides: Recent Progress and Promising Perspectives Toward Biomedical Applications DOI Creative Commons
Lei Li, Irem Soyhan, Eliza M. Warszawik

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(20)

Published: March 19, 2024

Abstract Layered double hydroxides (LDHs) have been widely studied for biomedical applications due to their excellent properties, such as good biocompatibility, degradability, interlayer ion exchangeability, high loading capacity, pH‐responsive release, and large specific surface area. Furthermore, the flexibility in structural composition ease of modification LDHs makes it possible develop specifically functionalized meet needs different applications. In this review, recent advances applications, which include LDH‐based drug delivery systems, cancer diagnosis therapy, tissue engineering, coatings, functional membranes, biosensors, are comprehensively discussed. From these various research fields, can be seen that there is great potential possibility use However, at same time, must recognized actual clinical translation still very limited. Therefore, current limitations related on discussed by combining limited examples with requirements biomaterials. Finally, an outlook future provided.

Language: Английский

Citations

27
Materials Containing Single‐, Di‐, Tri‐, and Multi‐Metal Atoms Bonded to C, N, S, P, B, and O Species as Advanced Catalysts for Energy, Sensor, and Biomedical Applications DOI Creative Commons
Jitendra N. Tiwari, Krishan Kumar, Moein Safarkhani

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(33)

Published: July 1, 2024

Abstract Modifying the coordination or local environments of single‐, di‐, tri‐, and multi‐metal atom (SMA/DMA/TMA/MMA)‐based materials is one best strategies for increasing catalytic activities, selectivity, long‐term durability these materials. Advanced sheet supported by metal atom‐based have become a critical topic in fields renewable energy conversion systems, storage devices, sensors, biomedicine owing to maximum utilization efficiency, precisely located centers, specific electron configurations, unique reactivity, precise chemical tunability. Several offer excellent support are attractive applications energy, medical research, such as oxygen reduction, production, hydrogen generation, fuel selective detection, enzymatic reactions. The strong metal–metal metal–carbon with metal–heteroatom (i.e., N, S, P, B, O) bonds stabilize optimize electronic structures atoms due interfacial interactions, yielding activities. These provide models understanding fundamental problems multistep This review summarizes substrate structure‐activity relationship different active sites based on experimental theoretical data. Additionally, new synthesis procedures, physicochemical characterizations, biomedical discussed. Finally, remaining challenges developing efficient SMA/DMA/TMA/MMA‐based presented.

Language: Английский

Citations

21
The role of graphene quantum dots in cutting‐edge medical therapies DOI

Kosar Arab,

Aliakbar Jafari,

Farangis Shahi

et al.

Polymers for Advanced Technologies, Journal Year: 2024, Volume and Issue: 35(9)

Published: Sept. 1, 2024

Abstract Graphene quantum dots (GQDs), owing to their unique optical, electrical, and chemical properties, have emerged as promising nanomaterials for various biomedical applications. This review provides a comprehensive overview of the latest advancements in utilization GQDs tissue engineering, wound healing, drug delivery systems, other therapies. The inherent properties GQDs, including high biocompatibility, tunable photoluminescence, significant surface area, make them ideal candidates enhancing medical treatments diagnostics. In improve mechanical biological performance scaffolds, promoting cell proliferation differentiation. For enhance antimicrobial activity facilitate faster regeneration. Their potential DDS is highlighted by ability deliver therapeutic agents efficiently, ensuring targeted controlled release. Additionally, play crucial role therapies, particularly cancer treatment, efficacy reducing side effects. While offer diagnostics, challenges such understanding long‐term cytotoxicity at higher concentrations, need standardized synthesis methods remain critical areas further research. also discusses future directions opportunities emphasizing transformative advancing modern healthcare solutions. insights presented here contribute expanding field GQD research, highlighting significantly patient outcomes drive innovations.

Language: Английский

Citations

11
Facile preparation of a pH-sensitive biocompatible nanocarrier based on magnetic layered double hydroxides/Cu MOFs-chitosan crosslinked к-carrageenan for controlled doxorubicin delivery to breast cancer cells DOI

Afsaneh Taghikhani,

Mirzaagha Babazadeh, Soodabeh Davaran

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 243, P. 114122 - 114122

Published: July 24, 2024

Language: Английский

Citations

10
Ascorbate-loaded Mg Fe layered double hydroxide for osteomyelitis treatment DOI
Wei Li, Yuliang Huang,

Dongqiang Gu

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 378, P. 1045 - 1060

Published: Jan. 5, 2025

Language: Английский

Citations

1
Nano‐High Entropy Materials in Electrocatalysis DOI

Xinyue Yan,

Yansong Zhou, Shuangyin Wang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 19, 2024

Abstract High entropy materials (HEMs) compositing of at least five elements have gained widespread attention in the field electrocatalysis due to their tunable activities and high stability. These intrinsic properties can be further highlighted when size HEMs comes nanoscale. In nanostructured HEMs, fascinating including large composition space, multi‐element synergy, configuration are expected endow nano‐HEMs with excellent catalytic activity stability, thus providing greater potential for design advanced electrocatalysts. this review, differentiated detail dimensions common synthesis methods summarized. Additionally, from perspective complex nanostructure‐performance relationship, applications systems, water‐splitting (hydrogen evolution reaction (HER), oxygen (OER)), hydrogen oxidation (HOR), reduction (ORR), carbon dioxide (CO 2 RR), nitrogen (NRR) alcohol (AOR) discussed. Finally, main challenges faced by underscored. This review is provide more insights into understanding developing efficient electrocatalytic practical applications.

Language: Английский

Citations

6
ZnFe Layered Double Hydroxide Nanosheets Loaded with Cu Single‐Atom Nanozymes with Multi‐Enzyme‐Like Catalytic Activities as an Effective Treatment for Bacterial Keratitis DOI Creative Commons
Keke Wang, Yuan Miao, Pengxiu Dai

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Abstract Bacterial keratitis (BK) is a type of corneal inflammation resulting from bacterial infection in the eye. Although nanozymes have been explored as promising materials wound healing, currently available lack sufficient catalytic activity and ability to penetrate biofilms, limiting their efficacy against treatment BK. To remedy this, ZnFe layered double hydroxide (ZnFe‐LDH) nanosheets are loaded with Cu single‐atom (Cu‐SAzymes) aminated dextran (Dex‐NH 2 ), formation nanozyme DT‐ZnFe‐LDH@Cu, which possesses peroxidase (POD)‐, oxidase (OXD)‐, catalase (CAT)‐like activities. This enables generate reactive oxygen species (ROS), such hydroxyl radicals ( • OH), superoxide anion radical (O •− singlet 1 O ) hydrogen peroxide (H thereby killing bacteria causing infections. The surface Dex‐NH enabled DT‐ZnFe‐LDH@Cu biofilm adsorb onto extracellular polymeric substances (EPS) produced by biofilm. Additionally, successfully repaired P. aeruginosa ‐infected injury BK rabbit model more effectively than commercially tobramycin eye drops. was enabled, part, reduce promoting polarization pro‐inflammatory macrophages (M1) anti‐inflammatory (M2) decrease expression α‐smooth muscle actin (α‐SMA) promote healing without scar formation. study provides an innovative concept for holds great scientific value clinical application potential.

Language: Английский

Citations

0
The Opportunities and Challenges of Using Nanomaterials as Photocatalysts for the Degradation of Environmental Pollutants DOI
Jamshid Khan, Israf Ud Din, Abdulrahman I. Alharthi

et al.

Comments on Inorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 46

Published: Jan. 22, 2025

Language: Английский

Citations

0
Kirkendall Effect-Mediated Transformation of ZIF-67 to NiCo-LDH Nanocages as Oxidase Mimics for Multicolor Point-of-Care Testing of β-Galactosidase Activity and Escherichia coli DOI

Lu Chen,

Huan Cheng,

Rong Hu

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Early and portable detection of pathogenic bacteria is crucial for ensuring food safety, monitoring product quality, tracing the sources bacterial infections. Moving beyond traditional plate-culture counting methods, analysis active components offers a rapid means quantifying bacteria. Here, metal-organic framework (MOF)-derived NiCo-layered double hydroxide nanosheets (LDHs), synthesized via Kirkendall effect, were employed as highly effective oxidase mimics to generate reactive oxygen species (ROS). These ROS quickly etched gold nanobipyramids (Au NBPs), producing vivid multicolormetric response. Experimental results theoretical calculations indicated that exceptional oxidase-like activity NiCo-LDHs stemmed from presence bimetallic sites vacancies modulating local electronic structure LDHs. Additionally, β-galactosidase (β-Gal), biomarker Escherichia coli, reacted with p-aminophenyl-β-d-galactopyranoside (PAPG) form p-aminophenol (PAP), reducing agent which consumes ROS, thereby inhibiting etching Au NBPs. Furthermore, three-dimensional (3D)-printed point-of-care testing (POCT) shell was designed device visually detect β-Gal E. coli in conjugation smartphones. This study not only provides novel approach rational design nanozymes but also establishes portably visual biosensing platform detecting

Language: Английский

Citations

0
Advanced Nanobiocomposite Hydrogels Incorporating Organofunctionalized LDH for Soft Tissue Engineering Applications DOI Open Access
Ionuț-Cristian Radu, Eugenia Tanasӑ, Sorina Dinescu

et al.

Polymers, Journal Year: 2025, Volume and Issue: 17(4), P. 536 - 536

Published: Feb. 19, 2025

Nanocomposite hydrogels are gaining significant attention for biomedical applications in soft tissue engineering due to the increasing demand highly flexible and durable polymer materials. This research paper focused on investigating optimizing a procedure development of novel nanocomposite based poly(2-hydroxyethyl methacrylate)-co-(2-acrylamido-2-methylpropane sulfonic acid) (HEMA/AMPSA) copolymers. These were synthesized through grafting-through process, where network was formed using modified clay crosslinker. The layered double hydroxide (LDH) with 3-(trimethoxysilyl)propyl methacrylate (ATPM) recipe two-step procedure. hydrogel compositions optimized achieve high flexibility. developed materials analyzed their mechanical morphological properties tensile compressive tests, transmission electron microscopy (TEM), scanning (SEM), micro-computed tomography (micro-CT). swelling behavior, density, kinetic diffusion mechanism demonstrated specific characteristics LDH-ATPM further characterized Thermogravimetry (TGA), FTIR-ATR X-ray diffraction (XRD). Biological assessments human adipose-derived stem cells (hASCs) essential evaluate biocompatibility potential applications.

Language: Английский

Citations

0