A Smart Nanomedicine Unleashes a Dual Assault of Glucose Starvation and Cuproptosis to Supercharge αPD‐L1 Therapy DOI Creative Commons

Yiming Xu,

Yuan Wu,

Xinjie Zheng

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Combination therapy has become a promising strategy for promoting the outcomes of anti-programmed death ligand-1 (αPD-L1) in lung cancer. Among all, emerging strategies targeting cancer metabolism have shown great potency treating cancers with immunotherapy. Here, alteration glucose and copper metabolisms is found to synergistically regulate PD-L1 expression cells. Thus, an intelligent biomimetic nano-delivery system synthesized by camouflaging cell membranes onto oxidase-loaded Cu-LDHs (CMGCL) targeted interference. Such novel nanomedicine able induce cuproptosis upregulation significantly via self-amplified cascade reactions. Meanwhile, decent membrane coating, CMGCL exhibited biosafety, tumor-targeted efficiency anti-tumor effects LLC tumor-bearing mice models. Additionally, combination can sensitize therapeutic αPD-L1, substantially tumor inhibition both subcutaneous metastasis LLC-bearing Overall, these findings highlight potential connections between cuproptosis, offering approach integrating starvation,

Language: Английский

Recent progress on transition metal dichalcogenide-based composites for cancer therapy DOI
Bo Chen, Yue Dai, S.‐Y. Yang

et al.

Nanoscale, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Cancer remains a global health challenge, driving the need for advanced treatments. While transition metal dichalcogenides (TMDs) show promise in cancer therapy, their stability and efficacy require improvement. This study explores TMD-based composites as solution to enhance therapeutic potential. review begins by providing an overview of TMDs emphasizing preparation techniques fundamental properties. The focus is then shifted categorizing based on constituent materials, delving into various types, such TMD-organic, TMD-carbon, TMD-metal chalcogenide, TMD-metal, TMD-oxide composites, well more complex ternary multinary systems. We further explore key fabrication strategies, including hydrothermal/solvothermal methods surface deposition/coating techniques. Subsequently, applications treatment, chemotherapy, photothermal phototherapy, integrated combination therapies. Finally, critical challenges field perspectives potential directions future research are presented.

Language: Английский

Citations

0
Integrated electrode-electrolyte optimization to fabricate pinewood-derived carbon-permeated CoNi3S4(P) hybrid nanocomposites as redox-rich electrode materials for ultra-high energy density hybrid supercapacitors DOI

Samikannu Prabu,

Kung‐Yuh Chiang, Abdullah N. Alodhayb

et al.

Journal of Power Sources, Journal Year: 2025, Volume and Issue: 640, P. 236705 - 236705

Published: March 18, 2025

Language: Английский

Citations

0
Mechanochemical Loading of Doxorubicin on the Surface of Magnesium and Zinc-Based Layered Double Hydroxides DOI Open Access

Minerva Guadalupe Ventura Muñoz,

Jesús Alfredo Lara Cerón,

Manuel de Jesús Gallegos Saucedo

et al.

Processes, Journal Year: 2025, Volume and Issue: 13(4), P. 931 - 931

Published: March 21, 2025

In the search for technologies and materials to improve safety efficacy of active ingredients used in treating diseases, layered double hydroxides (LDHs) have been proposed as drug carriers since they can enhance effects even reduce toxicity. Doxorubicin (DOX) is one most widely studied antitumor drugs due its broad spectrum; however, low plasma bioavailability slow systemic clearance, only a small fraction reaches acts on tumor, so LDHs vehicles solve these disadvantages. The method load incubating LDH particles DOX solutions. this work, two additional methods, co-precipitation, mechanochemical reaction, were explored evaluate structural stability vehicle amount retained by structured magnesium/aluminum zinc/aluminum cations, which are common compositions design biomedical applications. structure degraded loading process, whereas stable against three processes. procedure, green sustainable technology, loaded highest content DOX.

Language: Английский

Citations

0
Ratiometric Fluorometry on Microfluidic Paper-Based Analytical Device for Simultaneous Glucose and Cholesterol Detection Using MnFe-Layered Double Hydroxides as Peroxidase Mimic DOI
Nattasa Kitchawengkul, Akarapong Prakobkij, Rattaporn Saenmuangchin

et al.

Sensors and Actuators B Chemical, Journal Year: 2025, Volume and Issue: unknown, P. 137671 - 137671

Published: March 1, 2025

Language: Английский

Citations

0
Mg-Co double hydroxide/lactoferrin composite coating on Ti-based orthopedic implants: A pioneering strategy for augmenting bone defect restoration DOI
Jiali Wang, Xiaofeng Wang, Xiaotong Shen

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 308, P. 142489 - 142489

Published: March 26, 2025

Language: Английский

Citations

0
Evaluating two series of layered double hydroxides in the fight against microorganisms DOI
Anna Donnadio, Tamara Posati,

Livia Ottaviano

et al.

Applied Clay Science, Journal Year: 2025, Volume and Issue: 271, P. 107789 - 107789

Published: March 31, 2025

Language: Английский

Citations

0
Gallium‐Magnesium Layered Double Hydroxide for Elevated Tumor Immunotherapy Through Multi‐Network Synergistic Regulation DOI
Jia Tan, Binbin Ding, Hao Chen

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Abstract Immunotherapeutic efficacy is often limited by poor immunogenicity, immunosuppressive tumor microenvironment (TME), and cytoprotective mechanisms, leading to low immune activation. To this end, here, L‐amino acid oxidase (LAAO) loaded gallium‐magnesium layered double hydroxide (MG‐LAAO) prepared for significantly enhanced immunotherapy through multi‐network synergistic regulation. First, MG‐LAAO induces cell pyroptosis initiating caspase‐1/GSDMD caspase‐3/GSDME pathways, further triggering immunogenic death (ICD). Then the released Ga 3+ mitochondrial iron overload, resulting in ferroptosis. In addition, also hinders autophagy of cells, reshapes (TME) neutralizing H + inhibiting lactic accumulation, thus destroying mechanism avoiding escape. Furthermore, synergy activates cGAS‐STING signaling pathway, generating powerful antitumor immunotherapy. This work highlights critical role synergies between block, pyroptosis, ferroptosis, ICD immunotherapy, demonstrating important effectively overcoming TME enhancing immunogenicity. particular, gallium‐induced revealed first time, providing theoretical support design new materials future.

Language: Английский

Citations

0
Defect-Engineered CoFe Layered Double Hydroxide Quantum Dots: Oxygen Vacancy-Driven Boost in Peroxidase-Mimic Catalysis for Multiplex Biomarker Sensing DOI
Zhongwei Yang, Xiaoyu Zhang, Longwei Wang

et al.

ACS Materials Letters, Journal Year: 2025, Volume and Issue: unknown, P. 1777 - 1785

Published: April 8, 2025

Language: Английский

Citations

0
Recent advances in CO2 capture and mineralization using layered double hydroxide-based materials: A review DOI

M. Hassan,

Sheikha F. Wahdain,

Sagheer A. Onaizi

et al.

Environmental Science and Pollution Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

Language: Английский

Citations

3
Zinc–Nickel Bimetallic Hydroxide Nanosheets Activate the Paraptosis–Pyroptosis Positive Feedback Cycle for Enhanced Tumor Immunotherapy DOI
Youdong Chen, Yujie Lu,

Huali Lei

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(43), P. 29913 - 29929

Published: Oct. 15, 2024

Immunotherapy holds significant promise for cancer treatment. However, the highly immunosuppressive nature of solid tumors limits its effectiveness. Herein, we developed bioactive zinc–nickel hydroxide (ZnNi(OH)4) nanosheets (NSs) that can effectively initiate paraptosis–pyroptosis positive feedback cycle through synergistic ionic effect, thereby mitigating immunosuppression and enhancing efficacy immunotherapy. The acid-sensitive ZnNi(OH)4 NSs releases Ni2+ Zn2+ in weakly acidic tumor microenvironment. released alleviated pyroptosis inhibition by inducing paraptosis inhibiting autophagic flux. Concurrently, triggered release endogenous within cell a coordination competition mechanism, further amplifying zinc overload-mediated pyroptosis. Interestingly, pyroptosis-associated oxidative stress endoplasmic reticulum promote Ni2+-mediated paraptosis, forming loop between paraptosis. This process not only kills cells but also stimulates strong inflammatory response, antitumor immune response immunotherapy efficacy. Overall, this study proposes an effective induction strategy based on metal ions demonstrates effectiveness potentiating

Language: Английский

Citations

2