Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13

Published: April 21, 2025

The deposition of drug-loaded nanoparticles within the skin structure has been a challenge due to inexorable barrier function. Unless specific like liposomes and lipid-based related vesicles, most cannot penetrate epidermal layers by themselves. This is reason why microneedle-based systems are nowadays straightforward in research. They can greatly bypass stratum corneum deposit supramolecular cargo entities dermal layers, which perform features such as drug-controlled release, targeting or stimuli-responsive behaviors. At this point, after more than 20 years research using nanoparticle-microneedle combination all positive results, clinical experience still so limited. Therefore, how it possible that everlasting promise translation these not reached real practice? In piece work, based on authors' review, series limiting factors regulatory framework guidelines identified discussed, while highlighted revolutionary advances biomedical field 3D-printing technology microfluidics will contribute accelerate nanoparticle-microneedle-based devices make their use entrance market.

Language: Английский