Hyaluronidase‐Responsive Bactericidal Cryogel for Promoting Healing of Infected Wounds: Inflammatory Attenuation, ROS Scavenging, and Immune Regulation

Advanced Science, Journal Year: 2024, Volume and Issue: 11(17)

Published: Feb. 13, 2024

Abstract Wounds infected with multidrug‐resistant (MDR) bacteria are increasingly threatening public health and challenging clinical treatments because of intensive bacterial colonization, excessive inflammatory responses, superabundant oxidative stress. To overcome this malignant burden promote wound healing, a multifunctional cryogel (HA/TA2/KR2) composed hyaluronic acid (HA), tannic (TA), KR‐12 peptides is designed. The exhibited excellent shape‐memory properties, strong absorption performance, hemostatic capacity. In vitro experiments demonstrated that in the can be responsively released by stimulation hyaluronidase produced bacteria, reaching robust antibacterial activity against Escherichia coli ( E. coli) , MDR Pseudomonas aeruginosa (MDR‐PA), methicillin‐resistant Staphylococcus aureus (MRSA) disrupting cell membranes. Furthermore, synergetic effect TA efficiently scavenge ROS decrease expression pro‐inflammatory cytokines (tumor necrosis factor (TNF)‐α & interleukin (IL)−6), as well modulate macrophage phenotype toward M2 type. vivo animal tests indicated effectively destroy healing process via accelerating angiogenesis re‐epithelialization. Proteomic analysis revealed underlying mechanism which mainly reshaped microenvironment inhibiting Nuclear kappa B (NF‐κB) signaling pathway activating Janus kinase‐Signal transducer activator transcription (JAK‐STAT6) pathway. Therefore, HA/TA2/KR2 promising dressing candidate for bacteria‐infected healing.

Language: Английский

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Research progress of natural polysaccharide-based and natural protein-based hydrogels for bacteria-infected wound healing

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 496, P. 153803 - 153803

Published: July 6, 2024

Language: Английский

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Antibacterial adhesive based on oxidized tannic acid-chitosan for rapid hemostasis

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 333, P. 121973 - 121973

Published: Feb. 22, 2024

Language: Английский

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All-in-One: A Multifunctional Composite Biomimetic Cryogel for Coagulation Disorder Hemostasis and Infected Diabetic Wound Healing

Nano-Micro Letters, Journal Year: 2025, Volume and Issue: 17(1)

Published: March 3, 2025

Abstract Traditional hemostatic materials are difficult to meet the needs of non-compressible bleeding and for coagulopathic patients. In addition, open wounds susceptible infection, then develop into chronic wounds. However, development integrated dressings that do not depend on coagulation pathway improve microenvironment remains a challenge. Inspired by porous structure composition natural extracellular matrix, adipic dihydrazide modified gelatin (GA), dodecylamine-grafted hyaluronic acid (HD), MnO 2 nanozyme (manganese dioxide)@DFO (deferoxamine)@PDA (polydopamine) (MDP) nanoparticles were combined prepare GA/HD/MDP cryogels through amidation reaction hydrogen bonding. These exhibited good fatigue resistance, photothermal antibacterial (about 98% killing ratios both Escherichia coli methicillin-resistant Staphylococcus aureus (MRSA) after 3 min near-infrared irradiation), reactive oxygen species scavenging, release, angiogenesis properties. Furthermore, in liver defect model rats with coagulopathy, cryogel displayed less shorter hemostasis time than commercial sponge. MRSA-infected diabetic wounds, could decrease wound inflammation oxidative stress, alleviate hypoxic environment, promote collagen deposition, induce vascular regeneration, showing better repair effect compared Tegaderm™ film. results indicated have great potential hemorrhage patients healing infected

Language: Английский

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Hyaluronic Acid Receptor‐Mediated Nanomedicines and Targeted Therapy

Small Methods, Journal Year: 2024, Volume and Issue: unknown

Published: July 23, 2024

Abstract Hyaluronic acid (HA) is a naturally occurring polysaccharide found in the extracellular matrix with broad applications disease treatment. HA possesses good biocompatibility, biodegradability, and ability to interact various cell surface receptors. Its wide range of molecular weights modifiable chemical groups make it an effective drug carrier for delivery. Additionally, overexpression specific receptors on surfaces many states enhances accumulation drugs at pathological sites through receptor binding. In this review, modification drugs, major proteins, latest advances receptor‐targeted nano delivery systems (DDS) treatment tumors inflammatory diseases are summarized. Furthermore, functions varying vivo selection methods different discussed.

Language: Английский

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3D bioprinted dynamic bioactive living construct enhances mechanotransduction-assisted rapid neural network self-organization for spinal cord injury repair

Bioactive Materials, Journal Year: 2025, Volume and Issue: 46, P. 531 - 554

Published: Jan. 8, 2025

Language: Английский

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Enhanced hemostatic efficacy of cryogel with copper ion-loaded mesoporous bioactive glasses for acute and persistent bleeding

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 12, 2025

Uncontrolled acute and persistent bleeding, as well with infection, is a great challenge because of the high mortality during treating patients injuries, complex surgery or bone marrow failure. Here, we develop an external form natural components which based on phosphorylated methacrylated gelatin (GelMA, G) cryogel (GP) loaded tannic acid (TA)-mixed copper ion (Cu2+) mesoporous bioactive glasses (MBG), named after GP@MBG-Cu-TA cryogel, to address goals reduce bleeding enhance antibacterial activity. Structurally, GP, MBG TA Cu2+ adheres GP via hydrogen bonding. In vitro, displays good biocompatibility, hemostatic antimicrobial capability. vivo studies, can effect in liver injury SD rats for aplastic anemia hemophilia A mice tail amputation bleeding. addition, accelerates skin wound repair bacterial contamination at site. sum, not only endowed dual function capability, but also stop objects either normal abnormal coagulation function. Thus, provides promising candidate dressing managing complications clinic.

Language: Английский

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Development and functionality analysis of lipoplex-loaded polysaccharide-based surface coatings for local nucleic acid delivery

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 673, P. 125330 - 125330

Published: Feb. 14, 2025

Language: Английский

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Silk Nonwoven Fabric‐Based Dressing with Antibacterial and ROS‐Scavenging Properties for Modulating Wound Microenvironment and Promoting Diabetic Wound Healing

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

The microenvironment of diabetic wounds is exceptionally complex, characterized notably by persistent bacterial infections and the excessive production reactive oxygen species (ROS). Traditional treatment methods often fall short achieving ideal results. Consequently, there an urgent need to develop implement more advanced efficient strategies effectively address complexity recalcitrance wounds. This study pioneers a novel approach fabricating silk fibroin-based nonwoven dressing (SF-Ag-HCA) under neutral conditions, integrating silver ions with dihydrocaffeic acid-modified fibroin. Uniquely, this achieves dual functionality: exceptional antibacterial efficacy against common pathogens (E. coli, S. aureus, P. aeruginosa) robust ROS-scavenging capabilities, mitigating oxidative stress promoting immune homeostasis. SF-Ag-HCA not only surpasses conventional materials in regulating wound but also accelerates re-epithelialization collagen deposition. Animal studies further validate its superior performance healing infected compared commercial alternatives. innovative represents significant advancement care, offering integrated, cost-effective solution tailored for complex chronic management.

Language: Английский

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Mild photothermal-driven nanorobots for infected wound healing through effective photodynamic therapy and wound microenvironment remodeling

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162255 - 162255

Published: April 1, 2025

Language: Английский

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