A Multifunctional Metal–Phenolic Nanocoating on Bone Implants for Enhanced Osseointegration via Early Immunomodulation

Advanced Science, Journal Year: 2024, Volume and Issue: 11(18)

Published: March 6, 2024

Abstract Surface modification is an important approach to improve osseointegration of the endosseous implants, however it still desirable develop a facile yet efficient coating strategy. Herein, metal–phenolic network (MPN) proposed as multifunctional nanocoating on titanium (Ti) implants for enhanced through early immunomodulation. With tannic acid (TA) and Sr 2+ self‐assembled Ti substrates, MPN coatings provided bioactive interface, which can facilitate initial adhesion recruitment bone marrow mesenchymal stem cells (BMSCs) polarize macrophage toward M2 phenotype. Furthermore, TA‐Sr accelerated osteogenic differentiation BMSCs. In vivo evaluations further confirmed modified via generating favorable osteoimmune microenvironment. general, these results suggest that promising strategy achieving better faster be easily utilized in future clinical applications.

Language: Английский

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Nano-Based Approaches in Surface Modifications of Dental Implants: A Literature Review

Molecules, Journal Year: 2024, Volume and Issue: 29(13), P. 3061 - 3061

Published: June 27, 2024

Rehabilitation of fully or partially edentulous patients with dental implants represents one the most frequently used surgical procedures. The work Branemark, who observed that a piece titanium embedded in rabbit bone became firmly attached and difficult to remove, introduced concept osseointegration revolutionized modern dentistry. Since then, an ever-growing need for improved implant materials towards enhanced material-tissue integration has emerged. There is strong belief nanoscale will produce superior generation high efficiency, low cost, volume. aim this review explore contribution nanomaterials implantology. A variety have been proposed as potential candidates surface customization. They can inherent antibacterial properties, provide conditions osseointegration, act reservoirs biomolecules drugs. Titania nanotubes alone combination biological agents drugs are tissue implants. Regarding immunomodulation order avoid rejection, titania nanotubes, graphene, biopolymers successfully utilized, sometimes loaded anti-inflammatory extracellular vesicles. Peri-implantitis prevention be achieved through properties metal nanoparticles chitosan hybrid coatings bearing antibiotic substances. For corrosion resistance various explored. However, even though these modifications shown promising results, future research necessary assess their clinical behavior humans proceed widespread commercialization.

Language: Английский

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Deep learning assisted prediction of osteogenic capability of orthopedic implant surfaces based on early cell morphology

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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Bone Regeneration: A Review of Current Treatment Strategies

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(6), P. 1838 - 1838

Published: March 8, 2025

Bone regeneration has emerged as a critical research and clinical advancement field, fueled by the growing demand for effective treatments in orthopedics oncology. Over past two decades, significant progress biomaterials surgical techniques led to development of novel solutions treating bone defects, surpassing use traditional autologous grafts. This review aims assess latest approaches regeneration, including autologous, allogenic, xenogenic grafts, naturally derived biomaterials, innovative synthetic substitutes such bioceramics, bioactive glasses, metals, polymers, composite materials, other specialized applications. A comprehensive literature search was conducted on PubMed, focusing studies published between 2019 2024, meta-analyses, reviews, systematic reviews. The evaluated range strategies, examining outcomes, materials used, techniques, effectiveness various defects. identified numerous studies, with inclusion criteria focused those exploring strategies. These provided valuable insights into biological outcomes different graft types. Results indicated that while advancements show promising potential, challenges remain optimizing therapeutic strategies across diverse patient populations settings. findings emphasize need an integrated approach combines scientific research, practice, technological innovation improve therapies. Further is required establish standardized protocols determine optimal application enhance quality care.

Language: Английский

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Phase-transformed lactoferrin/strontium-doped nanocoatings enhance antibacterial, anti-inflammatory and vascularised osteogenesis of titanium

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 287, P. 138608 - 138608

Published: Dec. 9, 2024

Language: Английский

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Advances in osteoimmunomodulation of biomaterials after intrabone implantation: Focus on surface hydrophilicity

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Biomaterials intended for intrabone implantation are extensively utilized in orthopedic and dental applications. Their surface properties, particularly hydrophilicity, significantly influence the biological interactions surrounding implant, ultimately determining implant's

Language: Английский

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Biomaterials for bone tissue engineering: achievements to date and future directions

Biomedical Materials, Journal Year: 2024, Volume and Issue: 20(1), P. 012001 - 012001

Published: Nov. 22, 2024

Abstract Advancement in medicine and technology has resulted into prevention of countless deaths increased life span. However, it is important to note that, the modern lifestyle altered food habits, witnessed life-style stresses road accidents leading several health complications one primary victims bone health. More often than ever, healthcare professionals encounter cases massive fracture, loss generation critical sized defects. Surgical interventions, through use grafting techniques are necessary such cases. Natural grafts (allografts, autografts xenografts) however, have major drawbacks terms delayed rehabilitation, lack appropriate donors, infection morbidity that shifted focus investigators direction synthetic grafts. By employing biomaterials based on tissue engineering (BTE), provide a more biologically acceptable approach establishing phases healing. In BTE, various materials utilized support enhance regeneration. Biodegradable polymers like poly-(lactic acid), poly-(glycolic poly-( ϵ -caprolactone) commonly used for their customizable mechanical properties ability degrade over time, allowing natural growth. PEG employed hydrogels promote cell adhesion Ceramics, as hydroxyapatite beta-tricalcium phosphate ( β -TCP) mimic mineral attachment, with -TCP gradually resorbing new forms. Composite materials, including polymer-ceramic polymer-glasses, combine benefits both ceramics/glasses offer enhanced biological properties. collagen, gelatin, chitosan matrix attachment formation, also offering antimicrobial Hybrid decellularized retain structure factors, while functionalized scaffolds incorporate growth factors or bioactive molecules further stimulate healing integration. The current review article provides insights could yield revolutionary improvements orthopedic medical fields. introduction section this focuses statistical information requirements globally its impact economy. later section, anatomy human bone, defects diseases pertaining limitations were detailed. Biopolymers, bioceramics, biometals-based discussed depth sections followed. then concludes summary addressing trends future prospects potential transplants.

Language: Английский

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Bioinspired Adhesive Hydrogel Platform with Photothermal Antimicrobial, Antioxidant, and Angiogenic Properties for Whole-Process Management of Diabetic Wounds

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Diabetic wound healing remains a major challenge in modern medicine. The persistent inflammation and immune dysfunction hinder angiogenesis by producing excessive ROS increasing the susceptibility to bacterial infection. In this study, we developed an integrated strategy for whole-process management of diabetic wounds based on bioinspired adhesive hydrogel platform with hemostasis, photothermal antimicrobial, antioxidant, anti-inflammatory, angiogenic properties. A composite (termed AQTGF) using poly(acrylic acid) (PAA) quaternized chitosan (QCS) as backbone materials loaded TA-Gd/Fe-bimetallic-phenolic coordination polymer was prepared. AQTGF displayed favorable mechanical properties, self-healing capabilities, adhesion characteristics, response performance. vitro experiments demonstrated that exhibits excellent antimicrobial capacity angiogenic, M2 macrophage phenotype polarizing addition, rat tail amputation liver hemostasis had Moreover, vivo studies have indicated can facilitate accelerating epidermal growth, promoting collagen deposition, modulating polarization, inhibiting inflammation, angiogenesis. conclusion, study provides adaptable holds promise treatment chronic wounds.

Language: Английский

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Enhancing the Implant Osteointegration via Supramolecular Co‐Assembly Coating with Early Immunomodulation and Cell Colonization

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Abstract Osteointegration, the effective coupling between an implant and bone tissue, is a highly intricate biological process. The initial stages of bone‐related immunomodulation cellular colonization play crucial roles, but have received limited attention. Herein, novel supramolecular co‐assembled coating strontium (Sr)‐doped metal polyphenol networks (MPN) modified with c(RGDfc) developed well‐characterized, for eliciting early colonization. results showed that (Sr‐MPN)@RGD significantly regulated polarization macrophages to M2 phenotype by controllable release Sr, promote adhesion marrow mesenchymal stem cells (BMSCs) RGD presented on MPN. Notably, attenuated osteoclast differentiation oxidative stress as well enhanced osteoblast angiogenesis due macrophage toward phenotype, which in turn has profound effect neighboring through paracrine signaling. In vivo manifested superior osseointegration maturation bare Ti‐rod or coated MPN Sr‐MPN. This work contributed design multifunctional coatings address complex process osteointegration from perspective orchestrating cell recruitment immunomodulatory strategies.

Language: Английский

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Effectively Guiding Cell Elongation and Alignment by Constructing Micro/Nano Hierarchical Patterned Titania on Titanium Substrate

Biotechnology and Bioengineering, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

ABSTRACT Based on the innate sensitivity of cell to substrate topographical cues, modulating cell‐directed growth behavior is crucial for promoting tissue repair and reconstruction. Although photolithography technology has been extensively employed fabricate a variety anisotropic patterned structures guide growth, it remains great challenge design high‐resolution micro/nano hierarchical directly onto medical titanium (Ti)‐based implants. Herein, we present rapid, reliable reproducible approach combining hydrothermal construct structure including micro‐strips porous composed TiO 2 nanotubes features. In vitro biological physicochemical analyses revealed that not only efficiently facilitate localization adsorption BSA molecules, but also enhances control behavior. The synergistic effect between physical limitation organizing cellular cytoskeleton at micropattern focal adhesion sits nanoscale can effectively cells maintain stable elongation alignment, even large micro‐stripe width 100 μm. This study presents promising strategy precisely multi‐level Ti using biomaterials with excellent biocompatibility. These functional hybrid micropatterns offer powerful platform regulating bioreagent behaviors in various applications engineering, regenerative medicine, drug screening, biosensors.

Language: Английский

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