bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 7, 2024
Abstract
Fluid
and
crystallized
intelligence
are
acknowledged
as
distinct
facets
of
cognitive
ability
during
brain
development,
but
the
specific
neural
substrates
molecular
mechanisms
underlying
them
remain
unclear.
This
study
used
a
sample
comprising
7471
young
adolescents
(mean
age
9.87
±
0.62
years)
from
ABCD
cohort
to
elucidate
differential
correlates
fluid
intelligence.
Our
findings
indicated
that
micro-level
MRI
phenotypes
such
water
diffusivity
were
closely
associated
with
intelligence,
whereas
macro-level
gray
matter
cortical
thickness
indicative
We
further
investigated
by
correlating
characteristic
markers
spatial
transcriptome
profiles
PET
imaging.
Results
showed
had
significant
associations
serotonin
glutamate
system,
while
was
related
serotonin,
dopamine
acetylcholine
system.
Furthermore,
we
examined
impacts
lifestyle
factors
on
these
two
forms
how
pathways
mediated
impacts.
investigation
suggested
physical
activities,
screen
use
sleep
duration
influenced
mainly
through
mGlu5
receptors
5HT1a
D2
receptors.
In
conclusion,
illustrated
basis
between
perspectives
neuroimaging,
neurotransmitters,
lifestyles
in
adolescents.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 26, 2024
Abstract
Objective
The
effect
of
screen
time
on
the
development
attention-deficit/hyperactivity
disorder
(ADHD)
symptoms,
as
well
brain,
and
neural
mechanisms
underlying
association
between
ADHD
symptoms
remain
unclear.
This
study
aims
to
examine
time,
using
large-scale
longitudinal
samples
from
Adolescent
Brain
Cognitive
Development
(ABCD)
study.
Method
From
ABCD
study,
we
extracted,
data
based
Child
Behavior
Checklist,
brain
structure
measures
10116
7880
children
(aged
9–10
years)
at
baseline
2-year
follow-up,
respectively.
We
used
linear
mixed-effects
model
baseline,
after
two
years.
also
examined
mediating
role
symptoms.
Results
Screen
was
associated
with
(β
=
0.032,
p
0.001)
thickness
some
cortical
regions
(right
temporal
pole:
β=-0.036,
false
discovery
rate
(FDR)-corrected
0.020;
left
superior
frontal
gyrus:
β=-0.028,
FDR-corrected
rostral
middle
β=-0.030,
0.020).
Moreover,
total
volume
partially
mediated
relationship
0.001,
0.023)
baseline.
Conclusion
These
results
suggest
that
influences
symptom
structure,
providing
insight
into
Furthermore,
interventions
reduce
may
help
improve
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 7, 2024
Abstract
Fluid
and
crystallized
intelligence
are
acknowledged
as
distinct
facets
of
cognitive
ability
during
brain
development,
but
the
specific
neural
substrates
molecular
mechanisms
underlying
them
remain
unclear.
This
study
used
a
sample
comprising
7471
young
adolescents
(mean
age
9.87
±
0.62
years)
from
ABCD
cohort
to
elucidate
differential
correlates
fluid
intelligence.
Our
findings
indicated
that
micro-level
MRI
phenotypes
such
water
diffusivity
were
closely
associated
with
intelligence,
whereas
macro-level
gray
matter
cortical
thickness
indicative
We
further
investigated
by
correlating
characteristic
markers
spatial
transcriptome
profiles
PET
imaging.
Results
showed
had
significant
associations
serotonin
glutamate
system,
while
was
related
serotonin,
dopamine
acetylcholine
system.
Furthermore,
we
examined
impacts
lifestyle
factors
on
these
two
forms
how
pathways
mediated
impacts.
investigation
suggested
physical
activities,
screen
use
sleep
duration
influenced
mainly
through
mGlu5
receptors
5HT1a
D2
receptors.
In
conclusion,
illustrated
basis
between
perspectives
neuroimaging,
neurotransmitters,
lifestyles
in
adolescents.
