Dendritic Molecular Baskets for Selective Binding of Toxic Methotrexate DOI Creative Commons
Nitesh Kumar, Tyler J. Finnegan,

Sagarika Taneja

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 12, 2024

Abstract We describe the preparation, assembly, recognition characteristics, and bioactivity of dendritic basket 6 12− . This novel cavitand has a deep aromatic pocket with three ( S )‐glutamic acid dendrons at rim to amplify water solubility prevent self‐association. 1 H NMR spectroscopy, calorimetry (ITC), mass spectrometry (ESI‐MS) measurements validate formation an inclusion complex between anticancer drug methotrexate (MTX 2− ) in K d =9.2 μM). To identify docking pose, comparison computed (DFT MM) experimental chemical shifts suggests that MTX folds inside (π⋅⋅⋅π), forming HBs peptidic while anchoring (C−H⋅⋅⋅π) through its N‐methyl group. In consequence, selectively binds competition structurally similar folic leucovorin (reversal poisoning agent). While host is biocompatible (HEK293; IC 50 >150 μM) produces [MTX⊂ ] 14− cell media, it experiences limitation pharmacokinetic sequestration as dihydrofolate reductase's affinity suggested prevail over Nonetheless, considering basket's biocompatibility, tunability, chemoselectivity, stands leading candidate pursuit effective abiotic antidote for poisoning.

Language: Английский

Nanotherapeutics for Alleviating Anesthesia‐Associated Complications DOI Creative Commons
Bin Lü, Ling Wei, Gaoxiang Shi

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(15)

Published: Feb. 11, 2024

Abstract Current management of anesthesia‐associated complications falls short in terms both efficacy and safety. Nanomaterials with versatile properties unique nano‐bio interactions hold substantial promise as therapeutics for addressing these complications. This review conducts a thorough examination the existing nanotherapeutics highlights strategies developing prospective nanomedicines to mitigate anesthetics‐related toxicity. Initially, general, regional, local anesthesia along commonly used anesthetics related prevalent side effects are introduced. Furthermore, employing nanotechnology prevent alleviate is systematically demonstrated from three aspects, that is, 1) safe nano‐formulization anesthetics; 2) nano‐antidotes sequester overdosed alter their pharmacokinetics; 3) pharmacodynamic activities treat Finally, prospects challenges facing clinical translation anesthesia‐related discussed. work provides comprehensive roadmap effective toxicity, which can potentially revolutionize

Language: Английский

Citations

9
Protective effects of diacerein against quinolinic acid–induced Huntington’s disease–like symptoms in adult zebrafish by targeting GSK-3β signalling DOI
Falguni Goel,

Vaishali Dobhal,

Shamsher Singh

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Language: Английский

Citations

1
Supported silver nanoparticles over starch-modified magnetic nanoparticles: Characterization, Its application for A3 coupling reactions, analgesic and anesthetic activities DOI
Junwei Lu,

Meilan Zhang,

Attalla F. El‐kott

et al.

Journal of Organometallic Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 123544 - 123544

Published: Jan. 1, 2025

Language: Английский

Citations

0
Targeted drug delivery in neurodegenerative diseases: the role of nanotechnology DOI Creative Commons

Rupal Dhariwal,

Mukul Jain, Y. Mir

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 29, 2025

Neurodegenerative diseases, characterized by progressive neuronal loss and cognitive impairments, pose a significant global health challenge. This study explores the potential of nanotherapeutics as promising approach to enhance drug delivery across physiological barriers, particularly blood–brain barrier (BBB) blood-cerebrospinal fluid (B-CSFB). By employing nanoparticles, this research aims address critical challenges in diagnosis treatment conditions such Alzheimer’s, Parkinson’s, Huntington’s diseases. The multifactorial nature these disorders necessitates innovative solutions that leverage nanomedicine improve solubility, circulation time, targeted while minimizing off-target effects. findings underscore importance advancing applications develop effective therapeutic strategies can alleviate burden neurodegenerative diseases on individuals healthcare systems.

Language: Английский

Citations

0
Clickable immune-microenvironment modulated hydrogels for spinal cord injury repair DOI
Luzhong Zhang, Jingjing Wei, Yuan Huang

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 679, P. 1079 - 1092

Published: Oct. 21, 2024

Language: Английский

Citations

2
Improvement of sleep duration and quality through GABAA receptor by whey protein hydrolysate containing DIQK as the active main compound DOI Creative Commons
Hyowon Lee,

Hyeongyeong Kim,

Cheng-Min Jin

et al.

Journal of Dairy Science, Journal Year: 2024, Volume and Issue: 107(11), P. 8811 - 8823

Published: May 31, 2024

This study characterized the sleep activity, mechanism, and active peptides of whey protein hydrolysates selected through behavioral analysis fruit-flies (Drosophila melanogaster). Sleep-inducing (WP) hydrolysate was fruit fly behavior analysis, activity measured using a pentobarbital model electroencephalographic analysis. The mechanism action confirmed γ-aminobutyric acid (GABA) receptor antagonist, peptide identified liquid chromatography-mass spectroscopy. Whey hydrolysate, prepared Alcalase Prozyme (WP-AP), increased time in dose-dependent manner. WP-AP significantly not only but also slow-wave showed an insomnia-alleviating effect caffeine-induced insomnia mouse model. In addition, gene expression levels GABA sub-type A (GABAA) receptors brains mice orally administered with WP-AP. Through mixture DIQK, VPPF peptide, contained estimated to exhibit due its high content, DIQK speculated be main -inducing ingredient. These results indicate that has potential used as new ingredient improve quality.

Language: Английский

Citations

1
Multidisciplinary integration of frontier technologies facilitating the development of anesthesiology and perioperative medicine in aging society DOI Creative Commons

Lize Xiong,

Jun‐Li Cao, Hailong Dong

et al.

Fundamental Research, Journal Year: 2024, Volume and Issue: 4(4), P. 795 - 796

Published: June 5, 2024

Language: Английский

Citations

0
Dendritic Molecular Baskets for Selective Binding of Toxic Methotrexate DOI Creative Commons
Nitesh Kumar, Tyler J. Finnegan,

Sagarika Taneja

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 12, 2024

We describe the preparation, assembly, recognition characteristics, and bioactivity of dendritic basket 6

Language: Английский

Citations

0
Dendritic Molecular Baskets for Selective Binding of Toxic Methotrexate DOI Creative Commons
Nitesh Kumar, Tyler J. Finnegan,

Sagarika Taneja

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 12, 2024

Abstract We describe the preparation, assembly, recognition characteristics, and bioactivity of dendritic basket 6 12− . This novel cavitand has a deep aromatic pocket with three ( S )‐glutamic acid dendrons at rim to amplify water solubility prevent self‐association. 1 H NMR spectroscopy, calorimetry (ITC), mass spectrometry (ESI‐MS) measurements validate formation an inclusion complex between anticancer drug methotrexate (MTX 2− ) in K d =9.2 μM). To identify docking pose, comparison computed (DFT MM) experimental chemical shifts suggests that MTX folds inside (π⋅⋅⋅π), forming HBs peptidic while anchoring (C−H⋅⋅⋅π) through its N‐methyl group. In consequence, selectively binds competition structurally similar folic leucovorin (reversal poisoning agent). While host is biocompatible (HEK293; IC 50 >150 μM) produces [MTX⊂ ] 14− cell media, it experiences limitation pharmacokinetic sequestration as dihydrofolate reductase's affinity suggested prevail over Nonetheless, considering basket's biocompatibility, tunability, chemoselectivity, stands leading candidate pursuit effective abiotic antidote for poisoning.

Language: Английский

Citations

0