Chiral nanosystem and chiral supraparticles for drug delivery: an expert opinion DOI
Mahfoozur Rahman, Jagdish Singh, Alhussain Aodah

et al.

Expert Opinion on Drug Delivery, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Introduction Chiral nanocarriers enhance therapeutic efficacy by improving in vivo stability and cellular uptake. Chemical functionalization reduces cytotoxicity, resulting favorable biocompatibility. Nanoparticles self-assemble into supraparticles, enhancing drug delivery through improved retention loading. Area covered This review covers chiral nanostructures their mechanisms, applications various healthcare applications. Expert Opinion The chirality of biomaterials is crucial for advancing nanomedicine. nanosystem interacting selectively with biological molecules, specificity efficacy. off-target effects improves outcomes. Research has focused on uptake elimination to ensure safety, nanomaterials also show promise optical sensing gene editing. Their biocompatibility ability supraparticles may make them ideal systems.

Language: Английский

Supramolecular Chiral Binding Affinity‐Achieved Efficient Synergistic Cancer Therapy DOI Creative Commons

Jinfeng Zhou,

Jiake Gu,

Xiaohuan Sun

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(16)

Published: Feb. 21, 2024

Supramolecular chirality-mediated selective interaction among native assemblies is essential for precise disease diagnosis and treatment. Herein, to fully understand the supramolecular chiral binding affinity-achieved therapeutic efficiency, nanoparticles (WP5⊃D/L-Arg+DOX+ICG) with chirality transfer from arginine (D/L-Arg) water-soluble pillar[5]arene (WP5) are developed through non-covalent interactions, in which an anticancer drug (DOX, doxorubicin hydrochloride) a photothermal agent (ICG, indocyanine green) successfully loaded. Interestingly, WP5⊃D-Arg show 107 folds stronger capability toward phospholipid-composed liposomes compared WP5⊃L-Arg. The enantioselective further triggers chirality-specific accumulation cancer cells. As consequence, WP5⊃D-Arg+DOX+ICG exhibits extremely enhanced chemo-photothermal synergistic efficacy (tumor inhibition rate of 99.4%) than that WP5⊃L-Arg+DOX+ICG 56.4%) under same condition. This work reveals breakthrough can induce surprisingly large difference therapy, providing strong support significance bio-application.

Language: Английский

Citations

17
Recent advance development in pillar[5]arene-based nanomaterials for cancer therapy DOI
Yu Dai, Wenqiang Yu,

Yu‐Shan Cheng

et al.

Chemical Communications, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

In this review, we summarize five different types of pillar[5]arene-based nanomaterials and their applications in chemotherapy, photodynamic therapy, photothermal multimodal synergistic therapy for tumors.

Language: Английский

Citations

0
A chiral supramolecular nanocatcher prepared by D-biotin-pillar[5]arene for the selective capture and targeted delivery of oxaliplatin enantiomers DOI
Cuiting Yang, Dandan Wang, Shuai Chen

et al.

Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 110820 - 110820

Published: Jan. 1, 2025

Language: Английский

Citations

0
Folic-acid-functionalized Fe3O4@C@Pt nanozyme for synergistic catalytic-photothermal tumor therapy DOI
Yanan Li,

Zhilong Xu,

Lei Fan

et al.

New Journal of Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The study presents a Fe 3 O 4 @C@Pt nanozyme, modified with folic acid, that efficiently targets tumor cells and inhibits growth through combined photothermal therapy catalysis.

Language: Английский

Citations

0
Pillar[n]arene‐Based Supramolecular Nanodrug Delivery Systems for Cancer Therapy DOI Open Access
Shubin Wei,

Xinyi Cui,

Tingting Li

et al.

ChemMedChem, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Abstract Macrocyclic supramolecular materials play an important role in encapsulating anticancer drugs to improve the efficiency and reduce toxicity normal tissues through host‐guest interactions. Among them, pillar[n]arenes, as emerging class of macrocyclic compounds, have attracted increasing attention drug delivery drug‐controlled release due their high biocompatibility, excellent chemistry, simplicity modification. In this review, we summarize research progress pillar[n]arene‐based nanodrug systems (SNDs) recent years field tumor therapy, including release, imaging diagnostics therapeutic modalities. Furthermore, opportunities major limitations SNDs for therapy are discussed.

Language: Английский

Citations

0
Enhanced Combination Therapy Through Tumor Microenvironment-Activated Cellular Uptake and ROS-Sensitive Drug Release Using a Dual-Sensitive Nanogel DOI Creative Commons
Jianming Yuan,

Q.G. Chen,

Mingxiang Zuo

et al.

Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

A facile approach for enhanced combination therapy using a low pH and NIR irradiation-dual sensitive nanogel.

Language: Английский

Citations

0
In Situ NADH-Activated BODIPY-Based Macrocyclic Supramolecular Photosensitizer for Chemo-Photodynamic Synergistic Tumor Therapy DOI
Zhuo Lei,

Ya-Hui Song,

Yongjun Leng

et al.

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Photodynamic therapy (PDT) based on supramolecular assembly has been receiving wide attention due to its great potential application in clinical treatment. Herein, we report a photoelectron "reservoir" (SPR) constructed by tetracationic boron dipyrromethene (BODIPY)-based macrocycle (BBox·4Cl), doxorubicin (Dox), and tumor-targeted β-cyclodextrin-grafted hyaluronic acid (HACD). Upon irradiation, BBox·4Cl can situ catalyze nicotinamide adenine dinucleotide (NADH) continuously generate electrons inject into SPR, which further transfers oxygen, inducing highly efficient hydroxyl radical generation even under hypoxia. Synergistically, Dox SPR as "pump" be encapsulated transport photoelectrons between two BODIPY units, while HACD "sponge" enrich the electrostatic interaction concentrate them closer space, facilitates intramolecular intermolecular transfer, respectively, significantly enhances of radicals. Meanwhile, electron replenishment causes NADH depletion redox dysfunction, thereby accelerating apoptosis achieving effective synergistic tumor therapy.

Language: Английский

Citations

0
Editorial: Supramolecular cancer therapeutic biomaterials-volume II DOI Creative Commons
Yong Yao,

Gui‐Fei Huo,

Ruibo Zhao

et al.

Frontiers in Chemistry, Journal Year: 2025, Volume and Issue: 13

Published: March 5, 2025

briefly introduce the research work of this new topic.Hepatocellular carcinoma (HCC) has fourth highest death rate among all cancer types worldwide. Programmed cell (PCD) is a key biological mechanism for controlling progression, tumor expansion and metastasis. In addition, Tumor microenvironment (TME) critical in influencing Overall survival (OS) immune response to immunotherapy interventions. From multi-omics perspective, combination PCD TME helps predict patients with liver cancer. Liu et al. analyzed changes classifiers used classify into two subgroups (high PVD-low low PVD-high TME). Next, they compared somatic mutation (TMB), response, functional annotation between groups. Finally, Western blot (WB) was performed. Immunohistochemistry (IHC) assessed on Human Protein Map (HPA). PCD-TME classifier, 23 PCD-related genes three were identified. Using model, patients' prognosis treatment can be accurately predicted. The results study provide tool clinical management hepatocellular help develop accurate strategies these (Liu 2024).Fluorescence imaging near-infrared-II region advantages centimeter-scale tissue penetration micron-scale spatial resolution, which sparked interest visualizing lymphatic system. Jin prepared HA@ICG nanoparticles based NIR-II fluorescence characteristics ICG, inhibited π-π stacking ICG molecules, had an ideal particle size surface modification, good duration could assess local microcirculation. vitro vivo studies demonstrated that it excellent photostability, biosafety visualization ability system, expected clinic (Zhang 2024). However, further needed validation disease models deep-seated tissues.In paper, Prof. Wang coworkers proposed metal-organic framework (MOF)-based nano-platform mitochondrial-targeted CO gas therapy drug therapy. They designed thiol-functionalized MOF (UiO-66-SH) combined resveratrol (RES) form UiO@FeCO@RES nano-platform. platform capable triggering decomposition by ATP within cells, releasing RES generating gas, achieving synergistic anti-cancer effects inhibiting ATPase disrupting mitochondrial function. Experimental show effectively target mitochondria release ROS, significantly enhancing killing effect cells (Wang 2025). This strategy combining provides ideas treatment.In mini-review Fukuhara focuses application progress dynamic stimuli-responsive supramolecular chemosensors detection, particular attention external stimulus solution-state hydrostatic pressure its role systems. Focusing mechanical force pressure, found HeLa regulates influx Ca²⁺ through piezo ion channel, mainly affecting intracellular pathway, have restore original state channel. These findings suggest importance systems (Matsumoto different pressure-responsive peptide scaffolds development reagents promote future mechanobiology.In summary, we highly value endeavors, understandings, outlooks every contributor domain therapeutic biomaterials. We sincerely hope issue offer perspective applying chemistry address biomedical issues encourage -depth field.

Language: Английский

Citations

0
Engineering nanodiamond platform for tumor light up and high-performance cancer treatment DOI
Hui Qiao, Jiangtao Wu, Dongmei Zhang

et al.

Particuology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Chiral Inorganic Polar BaTiO3/BaCO3 Nanohybrids with Spin Selection for Asymmetric Photocatalysis DOI

Yemeng Sun,

Yan Zhang,

Jingren Ni

et al.

Nano Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 19, 2024

Chirality-dependent photocatalysis is an emerging domain that leverages unique chiral light–matter interactions for enabling asymmetric catalysis driven by spin polarization induced circularly polarized light selection. Herein, we synthesize inorganic polar BaTiO3/BaCO3 nanohybrids via a hydrothermal method employing glucose as structural inducer. When excited opposite light, the same material exhibits significant catalysis, while enantiomers present preference. More importantly, preferred undergoes reversal with of CD signal. Systematic experimental results demonstrate more photogenerated carriers are generated in semiconductors under suitable irradiation, including spin-polarized electrons, which inhibits recombination electron–hole pairs and promotes activation oxygen molecules into reactive species, thus inducing this photocatalytic feature. This study provides valuable insights development highly efficient polarization-sensitive perovskite nanostructures promising candidates next-generation, multifunctional device applications.

Language: Английский

Citations

1