Fabrication of Interface Engineered S‐Scheme Heterojunction Nanocatalyst for Ultrasound‐Triggered Sustainable Cancer Therapy

Advanced Science, Journal Year: 2024, Volume and Issue: 11(15)

Published: Feb. 11, 2024

Abstract In order to establish a set of perfect heterojunction designs and characterization schemes, step‐scheme (S‐scheme) BiOBr@Bi 2 S 3 nanoheterojunctions that enable the charge separation expand scope catalytic reactions, aiming promote development improvement engineering is developed. this kind system, Fermi levels mediate formation internal electric field at interface guide recombination weak redox carriers, while strong carriers are retained. Thus, these high‐energy electrons holes able catalyze variety substrates in tumor microenvironment, such as reduction oxygen carbon dioxide superoxide radicals monoxide (CO), oxidation H O hydroxyl radicals, thus achieving sonodynamic therapy CO combined therapy. Mechanistically, generated reactive species damage DNA inhibit cancer cell energy levels, respectively, synergistically induce apoptosis. This study provides new insights into realization high efficiency low toxicity from unique perspective materials design. It anticipated therapeutic method will garner significant interest sonocatalytic nanomedicine field.

Language: Английский

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Surface Oxygen Vacancies and Corona Polarization of Bi₄Ti₃O₁₂ Nanosheets for Synergistically Enhanced Sonopiezoelectric Therapy

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(32), P. 22348 - 22359

Published: Aug. 1, 2024

Sonopiezoelectric therapy, an ultrasound-activated piezoelectric nanomaterial for tumor treatment, has emerged as a novel alternative modality. However, the limited catalytic efficiency is serious bottleneck its practical application. Excellent catalysts with high coefficients, good deformability, large mechanical impact surface area, and abundant catalytically active sites still need to be developed urgently. In this study, classical ferroelectric material, bismuth titanate (Bi4Ti3O12, BTO), selected sonopiezoelectric sensitizer therapy. BTO generates electron–hole pairs under ultrasonic irradiation, which can react substrates in sonocatalytic-driven redox reaction. Aiming further improve activity of BTO, modification oxygen vacancies treatment corona polarization are envisioned study. Notably, reduces bandgap inhibits recombination. Additionally, immobilized built-in electric field on promoting separation electrons holes. Consequently, these modifications greatly sonocatalytic situ generation cytotoxic ROS CO, effectively eradicating tumor.

Language: Английский

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Bi2S3-based photocatalysts: Properties, synthesis, modification strategies, and mechanistic insights towards environmental sustainability and green energy technologies

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 529, P. 216443 - 216443

Published: Jan. 28, 2025

Language: Английский

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Empowering wastewater treatment with step scheme heterojunction ternary nanocomposites for photocatalytic degradation of nitrophenol

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 26, 2025

The ongoing challenge of water pollution necessitates innovative approaches to remove organic contaminants from wastewater. In this work, new two-dimensional S-scheme heterojunction photocatalysts Bi2O3/CdS and MoS2/Bi2O3/CdS that are intended for the effective photocatalytic destruction 4-nitrophenol, a dangerous pollutant, synthesized characterized. Utilizing solvothermal method, successfully generated these ternary nanocomposites, which were characterized through various techniques including X-ray diffraction (XRD), scanning electron microscopy (SEM), photoelectron spectroscopy (XPS), high resolution transmission electronmicroscopy (HRTEM), Brunauer-Emmett-Telle (BET) diffuse reflectance (DRS). Our results demonstrated achieved an 86% degradation rate while composite exhibited exceptional performance, achieving nearly complete (99%) within 120 min under visible light irradiation. Most importantly improved activity originated release internal electric field in heterojunction. This enhanced is attributable synergistic effects heterojunctions facilitate more charge separation generation with OP RP confirmed synthesis using S-scheme. further by XPS, DRS, XPS-VB photocurrent response. These findings highlight promising application advanced real-world wastewater treatment processes, offering sustainable solution combat pollution.

Language: Английский

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Nanosonosensitizer Optimization for Enhanced Sonodynamic Disease Treatment

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 23, 2024

Low-intensity ultrasound-mediated sonodynamic therapy (SDT), which, by design, integrates sonosensitizers and molecular oxygen to generate therapeutic substances (e.g., toxic hydroxyl radicals, superoxide anions, or singlet oxygen) at disease sites, has shown enormous potential for the effective treatment of a variety diseases. Nanoscale play crucial role in SDT process because their structural, compositional, physicochemical, biological characteristics are key determinants efficacy. In particular, advances materials science nanotechnology have invigorated series optimization strategies augmenting efficacy nanosonosensitizers. This comprehensive review systematically summarizes, discusses, highlights state-of-the-art studies on current achievements nanosonosensitizer enhanced treatment, with an emphasis general design principles nanosonosensitizers strategies, mainly including organic inorganic Additionally, recent advancements optimized applications aimed treating various diseases, such as cancer, bacterial infections, atherosclerosis, autoimmune clarified detail. Furthermore, effects improved versatile thoroughly discussed. The concludes highlighting challenges future opportunities this rapidly evolving research field expedite its practical clinical translation application.

Language: Английский

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γ-PGA-dependent growth of BiOBr nanosheets with exposed {010} facets for enhanced photocatalytic RhB degradation

Applied Surface Science, Journal Year: 2025, Volume and Issue: unknown, P. 162446 - 162446

Published: Jan. 1, 2025

Language: Английский

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Enhanced reactive oxygen species production for antibacterial treatment with ultrasound-activated 2D MXene-porphyrin MOF composite

Applied Surface Science, Journal Year: 2025, Volume and Issue: 688, P. 162327 - 162327

Published: Jan. 8, 2025

Language: Английский

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Catalase-assembled nanoparticles for PA/CT dual-modality imaging and repair of acute alcoholic gastritis

Biomaterials Advances, Journal Year: 2025, Volume and Issue: 169, P. 214181 - 214181

Published: Jan. 9, 2025

Language: Английский

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Nanomedicine-Enabled Concurrent regulations of ROS Generation and Copper Metabolism for Sonodynamic-Amplified Tumor Therapy

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123137 - 123137

Published: Jan. 1, 2025

Language: Английский

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Advances in Multimodal Synergistic Therapy Derived from Sonodynamic Therapy Mediated by BaTiO₃ Piezoelectric Nanomaterials in Tumor Treatment

Small Structures, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Tumors endanger the lives of individuals worldwide. They form and metastatize to nearby distant tissues organs in several ways, which greatly increase difficulty therapy. The continuous development progress nanomedicine has provided new insights treatment tumors. Owing their excellent properties barium titanate (BaTiO 3 , BTO), especially piezoelectricity, BTO‐based nanomaterials have become popular among tumor therapy researchers recent years. sonodynamic (SDT) is considerably advanced than traditional therapies. Herein, first, properties, structure, preparation technology, working mechanism BTO under ultrasonic stimulation systematically introduced. Second, research BTO‐mediated SDT, electrical therapy, SDT‐derived multimodal synergistic field reviewed. Third, biocompatibility, biodistribution, bioelimination summarized. Finally, current problems associated with SDT as well potential obstacles opportunities oncology other biomedical fields are summarized prospected.

Language: Английский

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