Brain Research, Journal Year: 2024, Volume and Issue: 1850, P. 149391 - 149391
Published: Dec. 9, 2024
Language: Английский
Advanced Science, Journal Year: 2024, Volume and Issue: 11(21)
Published: March 22, 2024
Abstract Neural stem cells (NSCs) transplantation is an attractive and promising treatment strategy for spinal cord injury (SCI). Various pathological processes including the severe inflammatory cascade difficulty in stable proliferation differentiation of NSCs limit its application translation. Here, a novel physico‐chemical bifunctional neural delivery system containing magnetic nanoparticles (MNPs methylprednisolone (MP) designed to repair SCI, former regulates through mechanical stimulation chronic phase, while latter alleviates response acute phase. The releases MP promote microglial M2 polarization, inhibit M1 reduce neuronal apoptosis. Meanwhile, tend differentiate into functional neurons with generated by MNPs static field, which related activation PI3K/AKT/mTOR pathway. SCI mice achieve better recovery after receiving via system, has milder inflammation, higher number microglia, more neurons, axonal regeneration. Together, this combined physical chemical drug therapy demonstrated be effective, provides new insights clinical transformation repair.
Language: Английский
Citations
15
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(34)
Published: May 14, 2024
Abstract Tissue vascularization plays a critical role in the regeneration and repair of damaged tissues. However, certain instances tissue injury, pace effectiveness can be limited. Innovative strategies leveraging magnetic fields nanoparticles (MNPs) are devised to enhance efficacy vascularization. This review explores potential field‐assisted augmenting repair. Direct application static or dynamic fields, alone combination with MNPs, offers means modulate cellular behaviors gene expression, thereby promoting angiogenesis regeneration. Techniques such as cell labeling, delivery using targeting have shown promise efficiently repairing various ischemic injuries by enhancing These broad applications bone skin regeneration, limb ischemia treatment, myocardial injury diabetic wound therapy. By summarizing recent advancements magnetically controlled strategies, this aims shed light on their future prospects clinical treatment.
Language: Английский
Citations
8
Life Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 123402 - 123402
Published: Jan. 1, 2025
Language: Английский
Citations
0
Small, Journal Year: 2025, Volume and Issue: 21(9)
Published: Jan. 22, 2025
Abstract Nanomaterials with unparalleled physical and chemical attributes have become a cornerstone in the field of nanomedicine delivery. These materials can be engineered into various functionalized nanocarriers, which focus research. Stimulus‐responsive nanodrug delivery systems (SRDDS) stand out as sophisticated class nanocarriers that release drugs response to environmental cues. Due complex pathogenesis multifaceted pathological environment nervous system, developing accurate effective drug therapy low side‐effects is formidable task. In recent years, SRDDS been widely used treatment neurological diseases. By customizing align specific microenvironment system tissues or external stimulation, efficacy enhanced. This review provides an in‐depth look at characteristics diseases highlights case studies tailored treat these disorders based on unique stimulation criteria triggers. Additionally, this comprehensive overview progress future prospects technology diseases, providing valuable guidance for its transition from fundamental research clinical application.
Language: Английский
Citations
0
Materials & Design, Journal Year: 2025, Volume and Issue: unknown, P. 113842 - 113842
Published: March 1, 2025
Language: Английский
Citations
0
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 23, 2025
Abstract Spinal cord injury (SCI) constitutes a critical occurrence that results in the disruption of both motor and sensory functions. Oxidative stress‐induced apoptosis pyroptosis have been identified as contributors to neuronal damage during secondary phase following SCI. Therefore, this study focuses on development self‐enhancing drug pair‐driven selenium (Se) nanotherapeutics, loading with 2,3,5,6‐tetramethylpyrazine (TMP) Ginsenoside Rg1 (Rg1), enhance treatment The engineered LET/TMP/Rg1@Se NPs exhibits remarkable antioxidant properties, effectively reducing oxidative by minimizing reactive oxygen species (ROS) accumulation restoring mitochondrial function. In addition their effects, nanotherapeutics demonstrates significant anti‐pyroptotic effects BV2 microglial cells modulating NLRP3/caspase‐1 pathway, leading decreased release pro‐inflammatory cytokines IL‐1β IL‐18. Moreover, inhibition inflammatory cascade response diminishes neuroinflammation‐induced promotes axonal regeneration neurons vitro. mouse model SCI, improved function regeneration, attributed pyroptosis, highlighting scientific basis for synergistic effect Se an innovative strategy effective SCI therapy.
Language: Английский
Citations
0
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 31, 2025
Abstract The diabetic tissue repair process is frequently hindered by persistent inflammation, infection risks, and a compromised microenvironment, which lead to delayed wound healing significantly impact the quality of life for patients. Electromagnetic biomaterials offer promising solution enabling intelligent detection wounds through electric magnetic effects, while simultaneously improving pathological microenvironment reducing oxidative stress, modulating immune responses, exhibiting antibacterial action. Additionally, these materials inherently promote regeneration regulating cellular behavior facilitating vascular neural repair. Compared traditional biomaterials, electromagnetic provide advantages such as noninvasiveness, deep penetration, responsiveness, multi‐stimuli synergy, demonstrating significant potential overcome challenges This review comprehensively examines superiority in repair, elucidates underlying biological mechanisms, discusses specific design strategies applications tailored characteristics wounds, with focus on skin bone defect By addressing current limitations pursuing multi‐faceted strategies, hold improve clinical outcomes enhance
Language: Английский
Citations
0
Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19
Published: May 12, 2025
Functional recovery following spinal cord injury (SCI) presents significant challenges and imposes a substantial burden on society. Current research primarily focuses minimizing damage promoting regeneration to enhance functional after SCI. Following SCI, secondary injuries such as mitochondrial dysfunction, vascular rupture, inflammatory responses, glial scarring occur in the lesion area, forming pathological microenvironment. These factors expand extent of damage, exacerbate severity, severely impede axonal Modulating microenvironment through various interventions may facilitate promote This article reviews influence advancements axon concerning response, scar formation Additionally, it integrates insights from bioengineering improve microenvironment, summarizing progress research. The review concludes with novel strategies for enhancing regeneration, offering fresh perspectives future investigations.
Language: Английский
Citations
0
Small, Journal Year: 2024, Volume and Issue: 20(46)
Published: Aug. 6, 2024
Abstract The strong anti‐inflammatory effect of methylprednisolone (MP) is a necessary treatment for various severe cases including acute spinal cord injury (SCI). However, concerns have been raised regarding adverse effects from MP, which also severely limits its clinical application. Natural polyphenols, due to their rich phenolic hydroxyl chemical properties, can form dynamic structures without additional modification, achieving targeted enrichment and drug release at the disease lesion, making them highly promising carrier. Considering application challenges natural polyphenolic platform employed efficient delivery reducing systemic side effects. Both in vitro SCI models demonstrated polyphenols multiple advantages as carriers delivering MP: (1) Achieved maximum injured site 2 h post‐administration, met desires early diseases; (2) Traceless MP; (3) Reducing effects; (4) Endowed system with new antioxidative an aspect that needs be addressed diseases treatment. This study highlighted prospect robust based on successfully overcome barrier MP treatment, providing possibility widespread
Language: Английский
Citations
3
Neurochemistry International, Journal Year: 2024, Volume and Issue: 178, P. 105801 - 105801
Published: July 5, 2024
Language: Английский
Citations
2