International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 669, P. 125101 - 125101
Published: Dec. 19, 2024
Language: Английский
Advanced Science, Journal Year: 2024, Volume and Issue: 11(26)
Published: May 2, 2024
Abstract Atherosclerotic cardiovascular disease (ASCVD) has become the leading cause of death worldwide, and early diagnosis treatment atherosclerosis (AS) are crucial for reducing occurrence acute events. However, AS is challenging, oral anti‐AS drugs suffer from limitations like imprecise targeting low bioavailability. To overcome aforementioned shortcomings, Cur/MOF@DS developed, a nanoplatform integrating by loading curcumin (Cur) into metal−organic frameworks with nanozymes magnetic resonance imaging (MRI) properties. In addition, surface‐modification dextran sulfate (DS) enables PCN‐222(Mn) effectively target scavenger receptor class A in macrophages or foam cells within plaque region. This employs mechanisms that scavenge excessive reactive oxygen species microenvironment, promote macrophage autophagy regulate polarization to realize lipid regulation. vivo vitro experiments confirm this outstanding MRI performance effects, which may provide new option AS.
Language: Английский
Citations
9
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 7, 2025
Atherosclerotic cardiovascular disease (ASCVD) causes significant morbidity and mortality globally. Most of the chemicals specifically target certain pathways minimally impact other diseases associated with ASCVD. Moreover, interactions these drugs can cause toxic reactions. Consequently, exploration multi-targeted safe medications for treating preventing ASCVD has become an increasingly popular trend. Gallic acid (GA), a natural secondary metabolite found in various fruits, plants, nuts, demonstrated potentials ASCVD, addition to its known antioxidant anti-inflammatory effects. It alleviates entire process atherosclerosis (AS) by reducing oxidative stress, improving endothelial dysfunction, inhibiting platelet activation aggregation. Additionally, GA treat ASCVD-related diseases, such as coronary heart (CHD) cerebral ischemia. However, pharmacological actions prevention treatment have not been comprehensively reviewed, which limits clinical development. This review primarily summarizes vitro vivo on related risk factors AS, it provides comprehensive overview toxicity, extraction, synthesis, pharmacokinetics, pharmaceutics GA,aimed enhance understanding applications further research
Language: Английский
Citations
0
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: April 23, 2025
Atherosclerosis is a complex cardiovascular disease driven by multiple factors, including aging, inflammation, oxidative stress, and plaque rupture. The progression of this often covert, emphasizing the need for early biomarkers effective intervention measures. In recent years, advancements in therapeutic strategies have highlighted potential targeting specific processes atherosclerosis, such as localization, macrophage activity, key enzymes. Based on this, review discusses role targeted drugs treatment atherosclerosis. It also focuses their clinical efficacy anti-atherosclerosis ability to provide more precise approaches. findings underscore that future research can concentrate exploring newer drug delivery systems further refine enhance long-term dynamic management
Language: Английский
Citations
0
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: April 24, 2025
Abstract Cardiovascular disease (CVD) is one of the most critical diseases which predominant cause death in world. Early screening and diagnosis effective treatment after play an important role patient's recovery. Metal–organic frameworks (MOFs), a kind hybrid ordered micro or meso‐porous materials, constructed by metal nodes clusters with organic ligands, due to their special features like high porosity specific surface area, open sites, ligand tunability, are widely used various areas including gas storage, catalysis, sensors, biomedicine. Recently, advances MOFs bringing new developments opportunities for healthcare industry theranostic CVD. In this review, applications illustrated therapy CVD, biomarker detection, imaging, drug delivery systems, therapeutic platforms, nanomedicine. Also, toxicity biocompatibility discussed. By providing comprehensive summary played CVDs, it hoped promote future theranostics, especially CVDs.
Language: Английский
Citations
0
International Journal of Pharmaceutics X, Journal Year: 2024, Volume and Issue: 8, P. 100310 - 100310
Published: Dec. 1, 2024
Curcumin (CUR) is highly promising for topical therapeutic applications, but water-insolubility one of the major challenges plaguing its drugability, while conventional lipid nanocarriers are limited by low drug-carrying capacity, many additives, and complex processes. In current work, we constructed a composite carrier integrated with cyclodextrin metal-organic framework (γ-CD-MOF) nanosponge (β-CDNS), in which γ-CD-MOF had 13.9 % drug loading 267.1-fold increase solubility water CUR, β-CDNS showed bioadhesion further increasing solubility. The (γ-CD-MOF@β-CDNS) significantly improved vitro release transdermal permeation absorption properties excellent create an advantage local administration treating diseases high exudate, prevents affected area from deteriorating condition counter-absorption formulation. Thus, this contributes new option to address delivery insoluble drugs offers strategy clinical application CUR.
Language: Английский
Citations
2
Small, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 17, 2024
Abstract Staphylococcus aureus ( S. )‐infected osteomyelitis is a deep tissue infection that cannot be effectively treated with antibiotics. Microwave (MW) thermal therapy (MTT) and MW dynamic (MDT) based on MW‐responsive materials are promising for the of bacteria‐infected occurring in tissues In this work, system carbon nanotubes (CNTs)/Prussian blue (PB)/puerarin (Pue) stable network‐like structures constructed. The PB grown situ CNTs, its introduction not only reduces aggregation but large specific surface area mesoporous structure can also provide many active sites adsorption oxygen polar molecules. Pue natural anti‐inflammatory material inflammation at site. composite CNTs avoids skin effect thus improve dielectric reflection losses. response CNTs/PB/Pue mainly due to occurrence loss, multiple reflections scattering, interface polarization, dipole polarization. addition, under irradiation, produce reactive species (ROS), such as singlet 1 O 2 ), hydroxyl radical (·OH).
Language: Английский
Citations
1
Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 16(1), P. 2 - 2
Published: Dec. 24, 2024
Atherosclerosis, a pathological process propelled by inflammatory mediators and lipids, is principal contributor to cardiovascular disease incidents. Currently, drug therapy, the primary therapeutic strategy for atherosclerosis, faces challenges such as poor stability significant side effects. The advent of nanomaterials has garnered considerable attention from scientific researchers. Nanoparticles, liposomes polymeric nanoparticles, have been developed delivery in atherosclerosis treatment. This review will focus on how nanoparticles effectively improve safety efficacy, well continuous development optimization same material further explore current future opportunities this field.
Language: Английский
Citations
1
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 157265 - 157265
Published: Oct. 1, 2024
Language: Английский
Citations
0
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 669, P. 125101 - 125101
Published: Dec. 19, 2024
Language: Английский
Citations
0