Regulatory mechanisms of connexin26

Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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Integration of Functional Human Auditory Neural Circuits Based on a 3D Carbon Nanotube System

Advanced Science, Journal Year: 2024, Volume and Issue: 11(32)

Published: June 18, 2024

Abstract The physiological interactions between the peripheral and central auditory systems are crucial for information transmission perception, while reliable models neural circuits currently lacking. To address this issue, mouse human pathways generated by utilizing a carbon nanotube nanofiber system. super‐aligned pattern of scaffold renders axons bipolar multipolar neurons extending in parallel direction. In addition, electrical conductivity maintains electrophysiological activity primary neurons. from units system then co‐cultured showed that two kinds form synaptic connections. Moreover, progenitor cells cochlea cortex derived embryos to generate region‐specific organoids these assembled nanofiber‐combined 3D Using optogenetic stimulation, calcium imaging, recording, it is revealed functional connections formed neurons, as evidenced spiking postsynaptic currents. circuit model will enable study pathway advance search treatment strategies disorders neuronal connectivity sensorineural hearing loss.

Language: Английский

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The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Abstract The auditory circuit primarily consists of peripheral organs and neural pathways. Hearing loss (HL), as reported by the World Health Organization, affects more than one in eight people worldwide, often leading to severe dysfunction that detrimentally impacts patients' quality life. Therefore, reconstruction has emerged a persistent research hotspot challenge within biomedical field. Traditional methods for reconstruction, such drug therapy, hearing aids, cochlear implants (CIs), so on. To certain extent, it can help patients with HL improve their status. However, they possess inherent advantages limitations. Recent advancements biomaterials, gene editing, stem cells, organoids, other technologies have ushered new prospects treatment impairment. This review focuses on potential innovative editing recovery. It reviews current status inner ear hair cell (HC) regeneration, spiral ganglion neuron (SGN) organoid construction loop. Furthermore, discusses challenges associated these approaches explores future directions, aiming furnish comprehensive reference both clinical applications domain restoration.

Language: Английский

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Bioadhesive drug-loaded microparticles prolong drug retention in the middle ear and ameliorate cisplatin-induced hearing loss

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113728 - 113728

Published: April 1, 2025

Language: Английский

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Recent Progress in Generation of Inner Ear Organoid

Advanced Biology, Journal Year: 2024, Volume and Issue: 8(10)

Published: July 25, 2024

Abstract Inner ear organoids play a crucial role in hearing research. In comparison to other animal models and 2D cell culture systems, inner offer significant advantages for studying the mechanisms of development exploring novel approaches disease treatment. derived from human cells are more closely resemble normal organs function. The 3D system organoid enhances cell–cell interactions mimics internal environment. this review, progress limitations methods tissue‐specific progenitors pluripotent stem (PSCs) summarized, which may new insights into generating that terms morphology

Language: Английский

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