National Science Review,
Journal Year:
2024,
Volume and Issue:
12(2)
Published: Nov. 26, 2024
ABSTRACT
Maxillofacial
injuries
that
may
cause
severe
functional
and
aesthetic
damage
require
effective
immediate
management
due
to
continuous
exposure
diverse
microbial
populations.
Moreover,
drug
resistance,
biofilm
formation,
oxidative
stress
significantly
impede
timely
bacterial
removal
immune
function,
making
the
exploration
of
advanced
materials
for
maxillofacial
wound
healing
an
appealing
yet
highly
challenging
task.
Herein,
a
near-infrared
photothermal
sterilization
agent
was
designed,
encapsulated
with
liposomes
coated
ascorbic
acid
known
its
antioxidant
immune-regulatory
functions.
The
resulting
nanoparticles,
4TPE-C6T-TD@AA,
effectively
neutralize
reactive
oxygen
species
generated
by
lipopolysaccharides,
facilitate
conversion
pro-inflammatory
M1
macrophages
anti-inflammatory
M2
macrophages,
eliminate
>90%
Staphylococcus
aureus
Escherichia
coli
disrupting
physiological
functions
upon
808
nm
laser
irradiation.
In
vivo
experiments
demonstrate
4TPE-C6T-TD@AA
rapidly
eliminates
bacteria
from
infected
wounds
in
region
rats,
promotes
S.
aureus-infected
enhancing
collagen
formation
modulating
inflammatory
microenvironment.
conclusion,
this
study
presents
promising
therapeutic
strategy
combating
infections
excessive
inflammation
treating
injuries.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(22)
Published: April 11, 2024
Abstract
The
inflammatory
response
is
a
key
factor
affecting
tissue
regeneration.
Inspired
by
the
immunomodulatory
role
of
spermidine,
an
injectable
double
network
hydrogel
functionalized
with
spermidine
(DN‐SPD)
developed,
where
first
and
second
networks
are
formed
dynamic
imine
bonds
non‐dynamic
photo‐crosslinked
respectively.
single
before
photo‐crosslinking
exhibits
excellent
injectability
thus
can
be
printed
in
situ
to
form
hydrogels.
DN‐SPD
has
demonstrated
desirable
mechanical
properties
adhesion.
More
importantly,
“operando”
comparison
hydrogels
loaded
or
diethylenetriamine
(DETA),
sham
molecule
resembling
shown
similar
physical
properties,
but
quite
different
biological
functions.
Specifically,
outcomes
3
sets
vivo
animal
experiments
demonstrate
that
not
only
reduce
inflammation
caused
implanted
exogenous
biomaterials
reactive
oxygen
species
also
promote
polarization
macrophages
toward
regenerative
M2
phenotype,
DN‐DETA
hydrogel.
Moreover,
immunoregulation
translate
into
faster
more
natural
healing
both
acute
wounds
diabetic
wounds.
Hence,
local
administration
affords
simple
elegant
approach
attenuate
foreign
body
reactions
induced
treat
chronic
refractory
Journal of Materials Chemistry B,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Responsive
hydrogels
were
capable
of
achieving
the
spatiotemporally
controlled
release
polyphenol
that
relieved
severe
oxidative
stress
and
modulated
macrophage
polarization,
thus
accelerating
diabetic
wound
healing.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 28, 2025
Abstract
Conductive
hydrogels
are
highly
attractive
in
3D
bioprinting
of
tissue
engineered
scaffolds
for
skin
injury
repair.
However,
their
application
is
limited
by
mismatched
electrical
signal
conduction
mode
and
poor
printability.
Herein,
the
bioprinting‐assisted
fabrication
a
double‐layer
ionic
conductive
scaffold
using
newly
designed
biomimetic
bioink
(GHCM)
reported,
which
composed
gelatin
methacrylate
(GelMA),
oxidized
hyaluronic
acid
(OHA),
carboxymethyl
chitosan
(CMCS),
2‐methacryloyloxyethyl
phosphorylcholine
(MPC)
treatment
full‐thickness
defects.
The
combination
rigid
(GelMA)
dynamic
(OHA‐CMCS)
polymer
networks
imparts
GHCM
excellent
reversible
thixotropy,
enabling
good
printability,
allowing
creation
skin‐like
constructs
with
high
shape
fidelity
cell
activity
convenient
one‐step
bioprinting.
Moreover,
incorporation
zwitterionic
MPC
endows
signaling
pattern
similar
to
that
natural
tissue.
By
integrating
human
foreskin
fibroblasts
(HFF‐1),
umbilical
vein
endothelial
cells
(HUVECs),
immortalized
keratinocytes
(HaCaTs),
comprising
an
epidermal
layer
vascularized
dermal
created.
In
vivo
experiments
have
demonstrated
provide
appropriate
microenvironment
cellular
signaling,
growth,
migration,
differentiation,
ultimately
accelerating
re‐epithelialization,
collagen
deposition,
vascularization
wounds,
may
represent
general
versatile
strategy
precise
engineering
electroactive
tissues
regenerative
medicine
applications.
Macromolecular Rapid Communications,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 13, 2025
Abstract
Myocardial
infarction
(MI)
is
a
leading
cause
of
mortality
among
cardiovascular
diseases.
Following
MI,
the
damaged
myocardium
progressively
being
replaced
by
fibrous
scar
tissue,
which
exhibits
poor
electrical
conductivity,
ultimately
resulting
in
arrhythmias
and
adverse
cardiac
remodeling.
Due
to
their
extracellular
matrix‐like
structure
excellent
biocompatibility,
hydrogels
are
emerging
as
focal
point
tissue
engineering.
However,
traditional
lack
necessary
conductivity
restore
signal
transmission
infarcted
regions.
Imparting
while
also
enhancing
adhesive
properties
enables
them
adhere
closely
myocardial
establish
stable
connections,
facilitate
synchronized
contraction
repair
within
area.
This
paper
reviews
strategies
for
constructing
conductive
hydrogels,
focusing
on
application
MI
repair.
Furthermore,
challenges
future
directions
developing
discussed.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 11, 2025
Abstract
Self‐healing
hydrogels
are
intelligent
wound
dressings
to
repair
structural
damage
caused
by
limb
movement,
demonstrating
advantages
in
stretchable
management.
Chitosan
is
widely
used
the
preparation
of
due
biocompatibility
and
biodegradability.
However,
self‐healing
efficiency
mechanical
strength
chitosan
not
ideal.
To
address
issues,
three
hydrogels:
single
schiff
base
network
(OH),
double
schiff‐base
bond
hydrogel
(OHD),
borate
ester
bond/schiff
(OHPB)
designed.
The
time
OHPB
only
0.7
s
measured
real‐time
electrochemical
test,
while
OH
OHD
3.5
h
1.5
h.
Furthermore,
exhibits
desirable
tissue
adhesion.
Following
destruction‐repair
process,
CIP
exosome
loaded
(ec⊂OHPB)
displays
approximate
100%
drug
leakage
resistance
achieve
long‐term
antibacterial,
cells
migration
promotion
M2
polarization.
ec⊂OHPB
significantly
accelerates
infected
wounds
healing
relieving
inflammation,
facilitating
angiogenesis
collagen
deposition,
promoting
epidermal
remodeling.
Consequently,
with
instantaneous
property
enhanced
performance
makes
it
possible
broaden
application
prospects
dressings.
