Herbacetin as a Novel Ferroptosis Inhibitor for Mitigating Myocardial Damage Induced by Doxorubicin

Published: Jan. 1, 2025

Language: Английский

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Bimetallic NiCu‐MOF Protects DOX‐Induced Myocardial Injury and Cardiac Dysfunction by Suppressing Ferroptosis and Inflammation

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Abstract Doxorubicin (DOX), a potent anthracycline chemotherapeutic agent, is widely used in cancer treatment but associated with significant adverse effects, particularly DOX‐induced cardiomyopathy (DIC). DIC pathogenesis involves the generation of reactive oxygen species (ROS) and ferroptosis induction. Novel therapeutic strategies targeting antioxidant defenses inhibition are essential for mitigating DIC. An innovative bimetallic metal‐organic framework (MOF), NiCu‐MOF (NCM), developed, exhibiting multifaceted enzyme‐mimicking activities that effectively scavenge broad spectrum ROS. Additionally, NCM exhibits excellent iron‐chelating ability. In vitro experiments demonstrate significantly reduces cardiomyocyte death by attenuating ROS levels inhibiting ferroptosis. Furthermore, mouse model DIC, results substantial myocardial protection, evidenced improved cardiac function structural integrity. This protective effect attributed to suppression ferroptosis, preservation mitochondrial function, attenuation inflammatory responses. Collectively, these findings highlight biocompatible NCM's potential as novel cardioprotective agent offer promising strategy managing

Language: Английский

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ROS-mediated ferroptosis and pyroptosis in cardiomyocytes: An update

Life Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 123565 - 123565

Published: March 1, 2025

Language: Английский

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Aryl hydrocarbon receptor-regulated long non-coding RNAs: implications for glycolipid metabolism and prognosis in hepatocellular carcinoma

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: April 3, 2025

Background Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths with limited treatment options. Tumor metabolic disorder elevated in HCC and activates the aryl hydrocarbon receptor (AHR), transcription factor implicated cancer progression. However, role AHR regulating long non-coding RNAs (lncRNAs) their impact on glycolipid metabolism remains underexplored. Materials methods We investigated AHR’s influence several cell lines treated ligand. RNA sequencing was performed to identify differentially expressed (DE) lncRNAs mRNAs. analyzed differences then conducted functional pathway enrichment identified DE Furthermore, we constructed co-expression networks mRNAs survival analysis using The Cancer Genome Atlas (TCGA) data. Results substantial number DEG significant between them related progression, pathways such as PI3K-Akt, VEGF, PPAR signaling highlighted. A network utilized elucidate lncRNA–mRNA interactions regulation metabolism.Survival AHR-regulated associated poor prognosis, like ASAP1-IT1 RMDN2-AS1 . Conclusion This study clarifies gene expression HCC, revealing novel lncRNA biomarkers potential therapeutic targets that could aid HCC. Further research needed explore effects glucose-lipid

Language: Английский

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Wogonin attenuates septic cardiomyopathy by suppressing ALOX15-mediated ferroptosis

Acta Pharmacologica Sinica, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Language: Английский

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The TFRC as a prognostic biomarker and potential therapeutic target in cervical cancer: a preliminary study

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: April 15, 2025

Background Early detection and treatment of CIN or early-stage cervical cancer lead to better clinical outcomes compared treating advanced-stage patients. Thus, specific biomarkers for the diagnosis prognosis should be urgently explored. Methods We analyzed tumor based on genes closely related OS in database with GSE63514, GSE7803, GSE9750 TCGA data sets, top 20 core were screened out. Notably, transferrin receptor (TFRC) emerged as a prioritized candidate due its dual role cellular iron homeostasis oncogenic signaling. However, exact TFRC development progression remains unclear. then used various bioinformatics methods mathematical models analyze those data, aiming investigate significance illustrate association immunity. In addition, molecular function mechanisms revealed by gene ontology, Kyoto Encyclopedia Genes Genomes, set enrichment analysis. Immunohistochemistry was employed assess protein expression 19 cancers, 16 HSILs 15 normal tissues. Results highly expressed CESC datasets. Meanwhile, correlated pathological stage, lymph node metastasis, malignant degree lesions HPV infection status. Our analysis confirmed that higher tissues tissues, it also elevated HSIL relative determined IHC staining. Increased linked decreased overall survival (OS) ( p = 0.024), disease-specific (DSS) 0.009), progression-free interval (PFI) 0.007) different stages, T N significantly associated worse DSS. constructed nomogram model, contributed exhibited good predictive power Finally, we immunosuppression is high expression. Conclusions exhibits significant diagnostic prognostic value cancer.

Language: Английский

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Targeted delivery of Saikosaponin A and doxorubicin via hyaluronic acid-modified ZIF-8 nanoparticles for TNBC treatment: Inhibiting metastasis and reducing cardiotoxicity

Biomaterials Advances, Journal Year: 2024, Volume and Issue: 167, P. 214114 - 214114

Published: Nov. 12, 2024

Language: Английский

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New insights into the relationship of mitochondrial metabolism and atherosclerosis

Cellular Signalling, Journal Year: 2024, Volume and Issue: 127, P. 111580 - 111580

Published: Dec. 27, 2024

Language: Английский

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Polypeptide-Based Copper Ionophore for In Situ Glutathione-Triggered Chemodynamic and Chemotherapy

Molecular Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Intracellular copper ion homeostasis has become an attractive target for cancer therapy. Herein, we report a 2,2'-dipicolylamine (DPA) functionalized polyglutamate derivative (PDHB) which is capable of rapidly forming PDHB-copper complex (PDHB@Cu) due to the strong coordination ability pendant DPA with Cu

Language: Английский

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Exploring the mechanism of sesamin for the treatment of PM2.5-induced cardiomyocyte damage based on transcriptomics, network pharmacology and experimental verification

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 5, 2024

Introduction Exposure to fine particulate matter (PM 2.5 ) is known be associated with cardiovascular diseases. Sesamin (Ses) a natural phenolic compound found in sesame seeds and oil. Ferroptosis novel mode of cell death characterised by iron-dependent lipid peroxidation. This study aims explore whether PM can induce ferroptosis H9C2 cells investigate the precise protective mechanism Ses. Methods Based on transcriptomic data, may cardiomyocytes. The inducer erastin inhibitor ferrostatin-1 (Fer-1) were used illustrate mechanisms involved -induced injury. Using network pharmacology, pharmacological potential therapy targets Ses explored for treatment cardiomyocyte cultured pretreated Fer-1 or different concentrations Ses, then injury model was established using . Indicators oxidative responses, including total superoxide dismutase, reduced glutathione, glutathione peroxidase malondialdehyde, measured. expression levels ferroptosis-related proteins determined through Western blot analysis. Results demonstrate that induces exerts effect suppressing ACSL4-mediated ferroptosis. Discussion Overall, these findings elucidate which ameliorates detrimental effects

Language: Английский

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