Sonosynthetic Cyanobacteria Oxygenation for Self‐Enhanced Tumor‐Specific Treatment

Advanced Science, Journal Year: 2024, Volume and Issue: 11(29)

Published: June 12, 2024

Abstract Photosynthesis, essential for life on earth, sustains diverse processes by providing nutrition in plants and microorganisms. Especially, photosynthesis is increasingly applied disease treatments, but its efficacy substantially limited the well‐known low penetration depth of external light. Here, ultrasound‐mediated reported enhanced sonodynamic tumor therapy using organic sonoafterglow (ultrasound‐induced afterglow) nanoparticles combined with cyanobacteria, demonstrating proof‐of‐concept sonosynthesis (sonoafterglow‐induced photosynthesis) cancer therapy. Chlorin e6, a typical small‐molecule chlorine, formulated into to stimulate cyanobacteria sonosynthesis, which serves three roles, i.e., overcoming tissue‐penetration limitations light sources, reducing hypoxia, acting as sonosensitizer vivo suppression. Furthermore, sonosynthetic oxygenation suppresses expression hypoxia‐inducible factor 1α, leading reduced stability downstream SLC7A11 mRNA, results glutathione depletion inactivation peroxidase 4, thereby inducing ferroptosis cells. This study not only broadens scope microbial nanomedicine also offers distinct direction sonosynthesis.

Language: Английский

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A Dual‐Targeting Biomimetic Nanoplatform Integrates SDT/CDT/Gas Therapy to Boost Synergistic Ferroptosis for Orthotopic Hepatocellular Carcinoma Therapy

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Abstract The development of efficient therapeutic strategies to promote ferroptotic cell death offers significant potential for hepatocellular carcinoma (HCC) treatment. Herein, this study presents an HCC‐targeted nanoplatform that integrates bimetallic FeMoO 4 nanoparticles with CO‐releasing molecules, and further camouflaged SP94 peptide‐modified macrophage membrane enhanced ferroptosis‐driven multi‐modal therapy HCC. Leveraging the multi‐enzyme activities multivalent metallic elements, not only decomposes H 2 O generate oxygen alleviate tumor hypoxia but also depletes glutathione inactivate peroxides 4, which amplify sonodynamic under ultrasound (US) irradiation. Meanwhile, catalyzes Fenton reaction produce hydroxyl radicals chemodynamic therapy. Elevated intracellular reactive species trigger cascade release CO, leading lethal lipid peroxidation enhancing ferroptosis‐mediated This demonstrates robust anti‐tumor efficacy US irradiation favorable biosafety in both subcutaneous orthotopic HCC models, representing a promising approach Additionally, findings offer new insights into microenvironment modulation optimize US‐triggered cancer

Language: Английский

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Molecular Strategies for Constructing Epoxy‐Type Afterglow Probes in Disease Diagnosis and Treatment

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

Abstract Epoxy‐type afterglow luminescence is a cascade reaction of photochemical defects caused as result the formation and release epoxy intermediates, exhibiting continuous phenomenon that remains intrinsic after excitation, with extremely impressive signal‐to‐background ratio (SBR) level in vivo. Afterglow based on this epoxy‐type mechanism ideally suited for applications developments diagnosis treatment biological diseases. In tutorial review, work aims to deeply elaborate mechanisms materials present application imaging Lastly, future perspectives potential challenges technology preclinical diagnostic, therapeutic, predictive analyses, well clinical translations are discussed.

Language: Английский

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X-ray/γ-ray/Ultrasound-Activated Persistent Luminescence Phosphors for Deep Tissue Bioimaging and Therapy

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(42), P. 56519 - 56544

Published: Oct. 14, 2024

Persistent luminescence phosphors (PLPs) can remain luminescent after excitation ceases and have been widely explored in bioimaging therapy since 2007. In bioimaging, PLPs efficiently avoid tissue autofluorescence light scattering interference by collecting persistent signals the end of excitation. Outstanding signal-to-background ratios, high sensitivity, resolution achieved with PLPs. therapy, continuously produce therapeutic molecules such as reactive oxygen species removing sources, which realizes sustained activity a single dose stimulation. However, most are activated ultraviolet or visible light, makes it difficult to reactivate vivo, particularly deep tissues. recent years, sources penetration activate PLPs, including X-ray, γ-ray, ultrasound. Researchers found that various inorganic organic be ultrasound, making these valuable imaging deep-seated tumors. These X-ray/γ-ray/ultrasound-activated not systematically introduced previous reviews. this review, we summarize recently developed ultrasound luminescence. The biomedical applications deep-tissue also discussed. This review provide instructions for design deep-tissue-renewable further promote phototheranostics, noninvasive biosensing devices, energy harvesting.

Language: Английский

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Recent Development of Organic Afterglow Probes for Diagnosis and Treatment of Cancer

Targets, Journal Year: 2024, Volume and Issue: 2(4), P. 327 - 340

Published: Oct. 31, 2024

Afterglow imaging plays a crucial role in the cancer treatment field. In contrast to inorganic afterglow agents, organic agents possess easily modifiable structures and exhibit excellent biocompatibility, thereby presenting significant prospects for application tumor diagnosis management. this review, we summarize design principles applications of probes therapy. Finally, discuss future challenges

Language: Английский

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Multienzyme-like polyoxometalate for oxygen-independent sonocatalytic enhanced cancer therapy

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 681, P. 319 - 330

Published: Nov. 23, 2024

Language: Английский

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