International Journal of Clinicopathological Correlation,
Journal Year:
2024,
Volume and Issue:
8(2)
Published: Dec. 27, 2024
The
early
diagnosis
of
diseases
is
a
fundamental
aspect
contemporary
medicine,
crucial
for
enhancing
patient
prognosis
and
alleviating
healthcare
system
burdens.
Biomarkers—measurable
indicators
biological
processes
or
disease
states—have
emerged
as
pivotal
tools
in
diagnostics.
This
review
focuses
on
novel
biomarkers
detection
cancer,
cardiovascular
diseases,
inflammatory
conditions,
with
special
emphasis
liquid
biopsies,
circulating
tumor
DNA
(ctDNA),
cardiac
troponins,
cytokines,
exosome-based
markers.
Furthermore,
advancements
omics
technologies
artificial
intelligence
are
highlighted
transformative
this
field.
Despite
their
potential,
challenges
such
validation,
standardization,
practical
integration
into
clinical
workflows
persist.
Addressing
these
through
collaborative
research
will
ensure
play
central
role
diagnostics,
ultimately
advancing
global
outcomes.
Molecular Neurobiology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 17, 2025
Abstract
Neurodegenerative
diseases
(NDs)
like
Alzheimer’s,
Parkinson’s,
and
ALS
rank
among
the
most
challenging
global
health
issues,
marked
by
substantial
obstacles
in
early
diagnosis
effective
treatment.
Current
diagnostic
techniques
frequently
demonstrate
inadequate
sensitivity
specificity,
whilst
conventional
treatment
strategies
encounter
challenges
related
to
restricted
bioavailability
insufficient
blood–brain
barrier
(BBB)
permeability.
Recently,
exosomes—nanoscale
vesicles
packed
with
proteins,
RNAs,
lipids—have
emerged
as
promising
agents
potential
reshape
therapeutic
approaches
these
diseases.
Unlike
drug
carriers,
they
naturally
traverse
BBB
can
deliver
bioactive
molecules
affected
neural
cells.
Their
molecular
cargo
influence
cell
signaling,
reduce
neuroinflammation,
potentially
slow
neurodegenerative
progression.
Moreover,
exosomes
serve
non-invasive
biomarkers,
enabling
precise
while
allowing
real-time
disease
monitoring.
Additionally,
engineered
exosomes,
loaded
molecules,
enhance
this
capability
targeting
diseased
neurons
overcoming
barriers.
By
offering
enhanced
reduced
immunogenicity,
an
ability
bypass
physiological
limitations,
exosome-based
present
a
transformative
advantage
over
existing
approaches.
This
review
examines
multifaceted
role
of
NDDs,
emphasizing
their
capabilities,
intrinsic
functions,
advanced
vehicles.
Biosensors,
Journal Year:
2025,
Volume and Issue:
15(3), P. 197 - 197
Published: March 20, 2025
This
article
explores
the
development
and
application
of
innovative
piezoelectric
sensors
in
point-of-care
diagnostics.
It
highlights
significance
bedside
tests,
such
as
lateral
flow
electrochemical
providing
rapid
accurate
results
directly
at
patient’s
location.
paper
delves
into
principles
assays,
emphasizing
their
ability
to
detect
disease-related
biomarkers
through
mechanical
stress-induced
electrical
signals.
Various
applications
chemosensors
biosensors
are
discussed,
including
use
detection
cancer
biomarkers,
pathogens,
other
health-related
analytes.
also
addresses
integration
materials
with
advanced
sensing
technologies
improve
diagnostic
accuracy
efficiency,
offering
a
comprehensive
overview
current
advances
future
directions
medical
Advances in computational intelligence and robotics book series,
Journal Year:
2025,
Volume and Issue:
unknown, P. 107 - 138
Published: March 28, 2025
Next-generation
wearable
technologies
and
digital
twins
are
the
two
ingredients
that
make
field
of
individual
health
monitoring
innovation.
Digital
virtual
representations
people,
which
assimilate
data
from
devices
with
biometric
use
analytic
machine
learning
tools
to
produce
models
human
change
in
real-time.
The
biomechanical
equivalents
these
variables
help
enhancing
examination
cyclers'
physiological
alterations
a
way
creates
more
compelling
proposals
for
patient-oriented
medical
treatments.
By
integrating
this
twin
models,
healthcare
providers
can
simulate
scenarios,
predict
potential
risks,
tailor
treatment
plans
unique
needs
each
patient.
As
integration
continues
evolve,
it
promises
unlock
new
frontiers
personalized
tracking,
revolutionizing
individuals
clinicians
manage
wellness.
Frontiers in Medicine,
Journal Year:
2025,
Volume and Issue:
12
Published: April 8, 2025
Modern
healthcare
depends
fundamentally
on
clinical
biochemistry
for
disease
diagnosis
and
therapeutic
guidance.
The
discipline
encounters
operational
constraints,
including
sampling
inefficiencies,
precision
limitations,
expansion
difficulties.
Recent
advancements
in
established
technologies,
such
as
mass
spectrometry
the
development
of
high-throughput
screening
point-of-care
are
revolutionizing
industry.
biosensor
technology
wearable
monitors
facilitate
continuous
health
tracking,
Artificial
Intelligence
(AI)/machine
learning
(ML)
applications
enhance
analytical
capabilities,
generating
predictive
insights
individualized
treatment
protocols.
However,
concerns
regarding
algorithmic
bias,
data
privacy,
lack
transparency
decision-making
("black
box"
models),
over-reliance
automated
systems
pose
significant
challenges
that
must
be
addressed
responsible
AI
integration.
limitations
remain-substantial
implementation
expenses,
system
incompatibility
issues,
information
security
vulnerabilities
intersect
with
ethical
considerations
fairness
protected
information.
Addressing
these
demands
coordinated
efforts
between
clinicians,
scientists,
technical
specialists.
This
review
discusses
current
biochemistry,
explicitly
addressing
reference
intervals
barriers
to
implementing
innovative
biomarkers
medical
settings.
discussion
evaluates
how
advanced
technologies
multidisciplinary
collaboration
can
overcome
constraints
while
identifying
research
priorities
diagnostic
accessibility
better
delivery.
IGI Global eBooks,
Journal Year:
2025,
Volume and Issue:
unknown, P. 203 - 220
Published: March 7, 2025
This
chapter
explores
how
technology
is
transforming
cancer
education
and
support
for
survivors
healthcare
providers.
It
covers
innovations
like
mobile
apps,
telemedicine,
AI,
virtual
reality,
social
media,
highlighting
their
impact
on
sharing
information,
offering
support,
delivering
care.
Through
literature
reviews,
case
studies,
research,
the
assesses
effectiveness
of
these
tools
in
improving
patient
outcomes,
enhancing
provider
education,
creating
a
more
connected
care
community.
also
addresses
challenges
digital
literacy,
accessibility,
data
privacy,
insights
professionals,
policymakers,
tech
developers
to
optimize
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 22, 2025
The
development
of
portable,
cost-effective,
and
highly
sensitive
biosensors
for
real-time
biomarker
detection
is
crucial
advancing
point-of-care
testing
(POCT)
wearable
health
monitoring.
Here,
we
present
an
integrated
portable
electrochemical
sensor
(ip-ECS)
that
combines
gold
nanoparticles
(AuNPs)
MXene-modified
screen-printed
electrodes
(SPEs)
with
a
custom-designed,
low-power
electronic
system
monitoring
serum
biomarkers.
AuNPs
MXene
nanocomposite
significantly
enhances
the
performance
SPE
by
providing
high
density
active
sites,
improved
conductivity,
catalytic
activity.
two
model
molecules
(DA
UA)
validated
feasibility
ip-ECS,
achieving
limits
as
low
1.12
1.11
μM
UA
DA,
respectively.
Furthermore,
ip-ECS
was
successfully
applied
to
detect
Cys
C
in
human
serum,
showing
linear
response
range
50-5000
ng/mL
strong
correlation
(ρ
=
0.9556)
conventional
latex
immunoturbidimetry
(LIA).
Clinical
validation
using
samples
from
pregnant
women
revealed
elevated
levels
gestational
diabetes
mellitus
(GDM)
patients,
highlighting
sensor's
potential
early
GDM
risk
prediction.
represents
significant
step
forward
next-generation
POCT,
diagnostics,
personalized
medicine.
Advances in computational intelligence and robotics book series,
Journal Year:
2025,
Volume and Issue:
unknown, P. 89 - 124
Published: March 7, 2025
This
paper
explored
the
crucial
areas
of
cybersecurity
in
healthcare
industry,
stressing
need
to
defend
infrastructures
and
private
patient
information
against
online
attacks.
As
part
their
applications
electronic
(e-healthcare)
services
for
risk
management,
fraud
detection,
identity
authentication
effectively
mitigate
cyber
risks,
current
proposed
bimodal
access
gateway
using
artificial
neural
network
(ANN)
computer
algorithm
secure
e-healthcare
data
warehouse
infrastructure.
In
this
study,
distributed
cloud
Internet
Things
(IoT)
server
systems
were
created
connected
through
5G
radio
frequency
enable
grid
synchronization,
resource
allocation
service-level
optimization.
approach
was
adopted
strengthen
defense
keep
ahead
every
evolving
threats
repositories.
