Advancements in omics technologies: Molecular mechanisms of acute lung injury and acute respiratory distress syndrome (Review) DOI

Zhihuan Zheng,

Xinyu Qiao,

Junhao Yin

et al.

International Journal of Molecular Medicine, Journal Year: 2024, Volume and Issue: 55(3)

Published: Dec. 27, 2024

Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is an inflammatory response arising from and systemic with diverse causes associated high rates of morbidity mortality. To date, no fully effective pharmacological therapies have been established the relevant underlying mechanisms warrant elucidation, which may be facilitated by multi‑omics technology. The present review summarizes application technology in identifying novel diagnostic markers therapeutic strategies ALI/ARDS as well its pathogenesis.

Language: Английский

Roles and Potential Mechanisms of Endothelial Cell-Derived Extracellular Vesicles in Ischemic Stroke DOI
Xinyuan Yu, Yiwei Huang,

Changxin Li

et al.

Translational Stroke Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

Language: Английский

Citations

1
Endothelial Cell‐Derived Extracellular Vesicles Promote Aberrant Neutrophil Trafficking and Subsequent Remote Lung Injury DOI Creative Commons
Shuangfeng Zi, Xiaojing Wu, Ying Tang

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(38)

Published: Aug. 9, 2024

The development of acute respiratory distress syndrome (ARDS) in sepsis is associated with substantial morbidity and mortality. However, the molecular pathogenesis underlying sepsis-induced ARDS remains elusive. Neutrophil heterogeneity dysfunction contribute to uncontrolled inflammation patients ARDS. A specific subset neutrophils undergoing reverse transendothelial migration (rTEM), which characterized by an activated phenotype, implicated systemic dissemination inflammation. Using single-cell RNA sequencing (scRNA-seq), it identified functionally exhibiting rTEM phenotype lung a mouse model using cecal ligation puncture. prevalence elevated blood sepsis-associated positively correlated disease severity. Mechanically, scRNA-seq proteomic analys revealed that inflamed endothelial cell (EC) released extracellular vesicles (EVs) enriched karyopherin subunit beta-1 (KPNB1), promoting abluminal-to-luminal neutrophil rTEM. Additionally, EC-derived EVs are proportion clinical sepsis. Collectively, EV as critical regulator rTEM, providing insights into contribution injury.

Language: Английский

Citations

6
Ethyl Caffeate Alleviates Inflammatory Response and Promotes Recovery in Septic-Acute Lung Injury via the TNF-α/NF-κB/MMP9 Axis DOI

Yuan‐Lan Huang,

Gang Li, Dan Li

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156700 - 156700

Published: March 1, 2025

Language: Английский

Citations

0
Inflammatory indices reflect distinct pathogenic cellular programs driving sepsis progression: The role of mmp9 protein macromolecules DOI

Bangjiang Fang,

Linguangjin Wu,

Li Zhang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143024 - 143024

Published: April 1, 2025

Language: Английский

Citations

0
Plasma-derived extracellular vesicles prime alveolar macrophages for autophagy and ferroptosis in sepsis-induced acute lung injury DOI Creative Commons

Rongzong Ye,

Yating Wei, Jingwen Li

et al.

Molecular Medicine, Journal Year: 2025, Volume and Issue: 31(1)

Published: Feb. 4, 2025

Abstract Sepsis-induced acute respiratory distress syndrome (ARDS) is a severe complication of sepsis and the leading cause mortality. Although role alveolar macrophages (AMs) in stabilizing pulmonary homeostasis well established, effects circulating extracellular vesicles (EVs) on AMs remain largely unknown. In this study, an investigation was conducted to map miRNA protein expression profiles EVs derived from septic plasma. Notably, EV-based panels (miR-122-5p, miR-125b-5p, miR-223-3p, OLFM4, LCN2) have been found be associated with severity or prognosis sepsis, promising AUC values. Moreover, levels LCN2, miR-122-5p, miR-223-3p were identified as independent predictors ARDS. The vitro coculture results revealed that LPS-EVs plasma sepsis-induced lung injury (ALI), which carry pro-inflammatory EVs, partly mediated by evidenced promotion inflammation, autophagy ferroptosis AMs. Mechanistically, upregulation triggers activating Hippo signaling via targeting MEF2C. vivo, inhibition effectively mitigated LPS-EV-induced inflammation AM death lungs, histological lesions. Overall, contributes ALI priming for through MEF2C/Hippo pathway. These findings suggest novel mechanism plasma-AM interaction ALI, offering plausible strategy assessing progression treating injury.

Language: Английский

Citations

0
MCTR1 ameliorates LPS-induced lung injury by inhibiting neutrophil reverse transendothelial migration DOI
Cheng Yang, Xiao Yuan, Deming Wang

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 157, P. 114777 - 114777

Published: May 7, 2025

Language: Английский

Citations

0
Advancements in omics technologies: Molecular mechanisms of acute lung injury and acute respiratory distress syndrome (Review) DOI

Zhihuan Zheng,

Xinyu Qiao,

Junhao Yin

et al.

International Journal of Molecular Medicine, Journal Year: 2024, Volume and Issue: 55(3)

Published: Dec. 27, 2024

Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is an inflammatory response arising from and systemic with diverse causes associated high rates of morbidity mortality. To date, no fully effective pharmacological therapies have been established the relevant underlying mechanisms warrant elucidation, which may be facilitated by multi‑omics technology. The present review summarizes application technology in identifying novel diagnostic markers therapeutic strategies ALI/ARDS as well its pathogenesis.

Language: Английский

Citations

1