Oxidative stress and cellular senescence: Roles in tumor progression and therapeutic opportunities DOI Creative Commons
Ping Jin, Xudong Feng, Chongan Huang

et al.

MedComm – Oncology, Journal Year: 2024, Volume and Issue: 3(4)

Published: Dec. 1, 2024

Abstract Oxidative stress results from an imbalance between the production and neutralization of reactive oxygen species. It induces oxidative damage to cellular components including proteins, lipids, nucleic acids, membranes, therefore intrinsically linking aging‐related diseases such as cancer, cardiovascular disease, neurological disorders. Emerging evidence suggests that may promote tumor development by influencing various aspects senescence, its onset, pro‐inflammatory secretion, alteration function structure. Modulating target senescence offers a novel strategy for cancer prevention treatment. However, thorough grasp specific mechanisms at play is lacking. This review will present association their regulatory role in progression treatment, with emphasis on senescence‐associated secretory phenotype, immunosenescence therapy‐induced senescence. Current agents strategies remove side effects via killing senescent cells or modulating improve antitumor efficacy be summarized. help readers better understand complex relationship also provide basis further research this area.

Language: Английский

PGC1α‐Inducing Senomorphic Nanotherapeutics Functionalized with NKG2D‐Overexpressing Cell Membranes for Intervertebral Disc Degeneration DOI Creative Commons
Sheng Liu,

Kanglu Li,

Yuxin He

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(22)

Published: March 30, 2024

Abstract Cellular senescence is a significant contributor to intervertebral disc aging and degeneration. However, the application of senotherapies, such as senomorphics targeting markers senescence‐associated secretory phenotype (SASP), remains limited due challenges in precise delivery. Given that natural killer group 2D (NKG2D) ligands are increased on surface senescent nucleus pulposus (NP) cells, NKG2D‐overexpressing NP cell membranes (NNPm) constructed, which expected achieve dual effect toward cells based homologous membrane fusion NKG2D‐mediated immunosurveillance mechanism. Then, mesoporous silica nanoparticles carrying peroxisome proliferator‐activated receptor‐ɣ coactivator 1α (PGC1α)inducer (SP) coated with NNPm (SP@NNPm) it found SP@NNPm selectively targets SP cores exhibit pH‐responsive drug release. Moreover, effectively induces PGC1α‐mediated mitochondrial biogenesis mitigates induced by oxidative stress SASP, thereby alleviating puncture‐induced This dual‐targeting nanotherapeutic system represents novel approach delivery for degeneration treatment.

Language: Английский

Citations

5
MicroSphere 3D Structures Delay Tissue Senescence through Mechanotransduction DOI
Ziang Li, Jincheng Tang, Liang Zhou

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

The extracellular matrix (ECM) stores signaling molecules and facilitates mechanical biochemical in cells. However, the influence of biomimetic "rejuvenation" ECM structures on aging- degeneration-related cellular activities tissue repair is not well understood. We combined physical extrusion precise "on–off" alternating cross-linking methods to create anisotropic biomaterial microgels (MicroRod MicroSphere) explored how they regulate cell nucleus pulposus (NP) their potential antidegenerative effects intervertebral discs. NP cells exhibited aligned growth along surface MicroRod, enhanced proliferation, reduced apoptosis. This suggests an adaptive response involving adhesion mechanosensing, which causes cytoskeletal extension via environmental cues. maintain nuclear membrane integrity through YAP/TAZ pathway, activates cGAS-STING pathway rectify aging mechanisms. In vivo, MicroRod carries reduces inflammatory factor protease secretion degenerated discs, inhibiting degeneration promoting regeneration. Our findings highlight role stress maintaining activity antiaging harsh environments, providing a foundation for further research development biomaterials.

Language: Английский

Citations

0
Natural Product-Derived Senotherapeutics: Extraction and Biological Evaluation Techniques DOI
Harris Pratsinis, Eleni Mavrogonatou, Sevasti‐Kiriaki Zervou

et al.

Methods in molecular biology, Journal Year: 2025, Volume and Issue: unknown, P. 315 - 359

Published: Jan. 1, 2025

Language: Английский

Citations

0
The anti-oxidation related bioactive materials for intervertebral disc degeneration regeneration and repair DOI

Yingjie Mai,

Siying Wu, Penghui Zhang

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 45, P. 19 - 40

Published: Nov. 9, 2024

Language: Английский

Citations

1
Oxidative stress and cellular senescence: Roles in tumor progression and therapeutic opportunities DOI Creative Commons
Ping Jin, Xudong Feng, Chongan Huang

et al.

MedComm – Oncology, Journal Year: 2024, Volume and Issue: 3(4)

Published: Dec. 1, 2024

Abstract Oxidative stress results from an imbalance between the production and neutralization of reactive oxygen species. It induces oxidative damage to cellular components including proteins, lipids, nucleic acids, membranes, therefore intrinsically linking aging‐related diseases such as cancer, cardiovascular disease, neurological disorders. Emerging evidence suggests that may promote tumor development by influencing various aspects senescence, its onset, pro‐inflammatory secretion, alteration function structure. Modulating target senescence offers a novel strategy for cancer prevention treatment. However, thorough grasp specific mechanisms at play is lacking. This review will present association their regulatory role in progression treatment, with emphasis on senescence‐associated secretory phenotype, immunosenescence therapy‐induced senescence. Current agents strategies remove side effects via killing senescent cells or modulating improve antitumor efficacy be summarized. help readers better understand complex relationship also provide basis further research this area.

Language: Английский

Citations

0