Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 504, P. 158713 - 158713
Published: Dec. 17, 2024
Language: Английский
Advanced Science, Journal Year: 2024, Volume and Issue: 11(21)
Published: April 6, 2024
Abstract Neutrophil extracellular traps (NETs) seriously impede diabetic wound healing. The disruption or scavenging of NETs using deoxyribonuclease (DNase) cationic nanoparticles has been limited by liberating trapped bacteria, short half‐life, potential cytotoxicity. In this study, a positive correlation between the level in exudation and severity inflammation patients is established. Novel bio‐based hydrogel microspheres ‘micro‐cage’, termed mPDA‐PEI@GelMA, engineered integrating methylacrylyl gelatin (GelMA) with polyethyleneimine (PEI)‐functionalized mesoporous polydopamine (mPDA). This unique ‘micro‐cage’ construct designed to non‐contact scavenge surface, minimizing biological toxicity ensuring high biosafety. are introduced into along exudation, mPDA‐PEI immobilizes them inside through strong binding affinity cfDNA web structure. findings demonstrate that mPDA‐PEI@GelMA effectively mitigates pro‐inflammatory responses associated wounds both vivo vitro. work introduces novel nanoparticle strategy enhance healing processes, benefits clinical applications.
Language: Английский
Citations
11
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 498, P. 155575 - 155575
Published: Sept. 7, 2024
Language: Английский
Citations
5
Biomarker Research, Journal Year: 2025, Volume and Issue: 13(1)
Published: Jan. 23, 2025
Neutrophil extracellular traps (NETs) are intricate, web-like formations composed of DNA, histones, and antimicrobial proteins, released by neutrophils. These structures participate in a wide array physiological pathological activities, including immune rheumatic diseases damage to target organs. Recently, the connection between NETs cancer has garnered significant attention. Within tumor microenvironment metabolism, exhibit multifaceted roles, such as promoting proliferation migration cells, influencing redox balance, triggering angiogenesis, driving metabolic reprogramming. This review offers comprehensive analysis link emphasizing areas that remain underexplored. include interaction with mitochondria, their effect on states within tumors, involvement reprogramming, contribution angiogenesis tumors. Such insights lay theoretical foundation for deeper understanding role development. Moreover, also delves into potential therapeutic strategies suggests future research directions, offering new perspectives treatment other related diseases.
Language: Английский
Citations
0
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113609 - 113609
Published: March 1, 2025
Language: Английский
Citations
0
Composites Part B Engineering, Journal Year: 2025, Volume and Issue: unknown, P. 112401 - 112401
Published: March 1, 2025
Language: Английский
Citations
0
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161767 - 161767
Published: March 1, 2025
Language: Английский
Citations
0
Small, Journal Year: 2025, Volume and Issue: unknown
Published: March 19, 2025
Abstract Hydrogel microspheres are important in regenerative medicine and tissue engineering, acting as cargos of cells, drugs, growth factors, bio‐inks for 3D printing, medical devices. The antimicrobial anti‐inflammatory characteristics hydrogel good treating injured tissues. However, the biological properties should be modified optimal treatment various body parts with different physiological biochemical environments. In addition, specific preparation methods required to produce customized shapes sizes clinical applications. Herein, advances biomedical applications reviewed. Synthesis precursor solutions, manufacturing methods, strategies enhancing functions these described. involvement bioactive repair is also discussed. This review anticipates fostering more insights into design, production, application biomedicine.
Language: Английский
Citations
0
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 30, 2025
Abstract Functional biomaterials composed of multiple biomacromolecules have significant advantages over those made from a single type. However, harmoniously integrating various remains challenging. Neutrophil extracellular traps (NETs), an emerging biological structure released neutrophils, serve as natural prototype worth investigating and learning from. NETs consist intricate exhibit web‐like microstructure, endowing them with multifaceted roles in both physiological pathological processes. In this review, research progress is systematically examined on materials science perspective. First, the origin transformation are introduced, their functional mechanisms NET components thoroughly dissected rather than conventionally treating entity. Second, given complex functions, revealed potential biomarker for disease prediction. Third, typical characterization technologies analysis summarized. Fourth, artificial inspired by discussed. addition, regulatory processes provide bio‐inspired prototypes design advanced materials. Finally, perspectives opportunities challenges advancing presented biomarkers models development
Language: Английский
Citations
0
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(8), P. 990 - 990
Published: July 26, 2024
Wound healing progresses through three distinct stages: inflammation, proliferation, and remodeling. Immune regulation is a central component throughout, crucial for orchestrating inflammatory responses, facilitating tissue repair, restraining scar formation. Elements such as mitochondria, reactive oxygen species (ROS), macrophages, autophagy, ferroptosis, cytokines collaboratively shape immune in this process. Skin wound dressings, recognized their ability to augment biomaterials’ immunomodulatory characteristics via antimicrobial, antioxidative, pro- or anti-inflammatory, tissue-regenerative capacities, have garnered heightened attention. Notwithstanding, lack of comprehensive research addressing how these dressings attain properties the mechanisms thereof persists. Hence, paper pioneers systematic review biomaterials, emphasizing underlying immunological mechanisms. It begins by highlighting importance peculiarities obstacles faced skin injury recovery. This segment explores impact metabolism, infections, systemic illnesses, local immobilization on response during healing. Subsequently, examines spectrum biomaterials utilized therapy, including hydrogels, aerogels, electrospun nanofiber membranes, collagen scaffolds, microneedles, sponges, 3D-printed constructs. elaborates approaches employed materials, focusing mitochondrial ROS modulation, autophagic processes, macrophage influence Acknowledging challenge antibiotic resistance, also summarizes promising plant-based alternatives biomaterial integration, curcumin. In its concluding sections, charts recent advancements prospects that accelerate modulation. includes exploring transplantation morphology optimization, metal ion incorporation, electrostimulation-enabled control, benefits composite materials immune-regulatory dressings. The ultimate objective establish theoretical foundation guide future investigations realm related science disciplines.
Language: Английский
Citations
2
Advances in Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 334, P. 103317 - 103317
Published: Oct. 21, 2024
Language: Английский
Citations
1