Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 498, P. 155189 - 155189
Published: Aug. 25, 2024
Language: Английский
Advanced Science, Journal Year: 2024, Volume and Issue: 11(25)
Published: April 22, 2024
Abstract Deep penetration and downregulation of heat shock protein (HSP) expression in multimodal synergistic therapy are promising approaches for curing cancer clinical trials. However, free small‐molecule drugs most drug vehicles have a low delivery efficiency deep into the tumor owing to poor hypoxic conditions at site. In this study, objective is use reactive oxygen species (ROS)‐responsive supramolecular gels co‐loaded with photosensitizer Zn(II) phthalocyanine tetrasulfonic acid (ZnPCS 4 ) functionalized tetrahedral DNA (TGSAs) (G@P/TGSAs) enhance tissue cell block HSP90 pathway chemo‐ photodynamic (PDT) ‐ photothermal (PTT) trimodal therapy. The injected situ release ZnPCS TGSAs under high ROS concentrations originating from both PDT. penetrate deeply tissues augment by inhibiting pathway. Proteomics show that HSP‐related proteins molecular chaperones inhibited/activated, Simultaneously, TGSA‐regulated apoptotic activated. vivo study demonstrates efficient excellent (45% growth inhibition).
Language: Английский
Citations
8
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 505, P. 159380 - 159380
Published: Jan. 8, 2025
Language: Английский
Citations
0
Chinese Journal of Chemical Engineering, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
0
ACS Materials Letters, Journal Year: 2025, Volume and Issue: unknown, P. 1431 - 1439
Published: March 19, 2025
Molecular agents with exceptional multifunctionality are highly sought for phototheranostic applications. Herein we present a high-performance polymer near-infrared II (NIR-II) fluorescence and photoacoustic (PA) imaging-guided mild photothermal therapy (mPTT) of tumors. We synthesize series semiconducting polymers based on pyrrolopyrrole cyanine, identifying that P(P-T) exhibits large mass extinction coefficient (139 L g–1 cm–1), excellent performance, bright NIR-II fluorescence, PA imaging signals, making it among the highest-performing in these properties. A tumor-targeting agent was developed by coencapsulating heat shock protein (HSP) inhibitor camouflaging M1 macrophage membranes. The integration enables comprehensive tumor site delineation, guiding subsequent therapeutic intervention. In 4T1 tumor-bearing mice, synergistic effect mPTT under low-power 808 nm laser irradiation, combined HSP inhibition, resulted significant suppression. This work offers valuable insights designing advanced agents.
Language: Английский
Citations
0
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(43), P. 58392 - 58404
Published: Oct. 16, 2024
Pyroptosis, a form of programmed cell death, holds great promise for breast cancer treatment. However, the downregulation gasdermin E (GSDME) limits effectiveness pyroptosis. To address this challenge, we developed folic acid-modified and glutathione/reactive oxygen species dual-responsive nanocarrier (FPSD NPs) targeted delivery doxorubicin (DOX). Through combination with DNA methyltransferase inhibitor decitabine (DAC), GSDME protein expression was significantly increased in 4T1 cells, resulting swelling ballooning, which are characteristic features In vivo experiments further demonstrated antitumor efficacy DAC + DOX@FPSD NPs, 4T1-bearing mice treated NPs exhibited reduced tumor volumes, minimized weights, decreased Ki67-positive TUNEL apoptosis ratios, pronounced lesions H&E staining. Furthermore, NP treatment could promote pyroptosis-associated immunity, as evidenced by presence CD3+, CD4+, CD8+ T heightened secretion necrosis factor-α interferon-γ, elevated high-mobility group box-1 levels, enhanced calreticulin exposure. The FPSD study had favorable stability, active targeting ability, biocompatibility, controlled release properties, represented an approach to therapy inducing pyroptosis, offers promising avenue
Language: Английский
Citations
3
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 155593 - 155593
Published: Sept. 1, 2024
Language: Английский
Citations
1
Small Methods, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Tetrahedral framework nucleic acids (tFNAs) are renowned for their controllable self-assembly, exceptional programmability, and excellent biocompatibility, which have led to widespread application in the biomedical field. Beyond these features, tFNAs demonstrate unique chemical biological properties including high cellular uptake efficiency, structural bio-stability, tissue permeability, derived from distinctive 3D structure. To date, an extensive range of tFNA-based nanostructures intelligently designed developed various applications such as drug delivery, gene therapy, biosensing, engineering, among other emerging fields. In addition role delivery systems, also possess intrinsic that render them highly effective therapeutic agents treatment complex diseases, arthritis, neurodegenerative disorders, cardiovascular diseases. This dual functionality significantly enhances utility research, presenting valuable opportunities development next-generation medical technologies across diverse diagnostic platforms. Consequently, this review comprehensively introduces latest advancements field, with a focus on benefits nanoplatforms, inherent capabilities agents. Furthermore, current limitations, challenges, future perspectives explored.
Language: Английский
Citations
1
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 498, P. 155189 - 155189
Published: Aug. 25, 2024
Language: Английский
Citations
0