ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(51), P. 70160 - 70173
Published: Dec. 11, 2024
In
recent
years,
field-effect
transistor
(FET)
sensing
technology
has
attracted
significant
attention
owing
to
its
noninvasive,
label-free,
real-time,
and
user-friendly
detection
capabilities.
Owing
the
large
specific
surface
area,
high
flexibility,
excellent
conductivity
of
two-dimensional
(2D)
materials,
FET
biosensors
based
on
2D
materials
have
demonstrated
unique
potential
in
biomarker
analysis
healthcare
applications,
driving
continuous
innovation
transformation
field.
Here,
we
review
trends
development
key
performance
metrics
main
characteristics,
also
discuss
structural
designs
modification
strategies
for
biosensing
devices
utilizing
graphene,
transition
metal
dichalcogenides,
black
phosphorus,
other
enhance
metrics.
Finally,
offer
insights
into
future
directions
biosensor
advancements,
improvements,
present
new
recommendations
practical
clinical
applications.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(31)
Published: June 18, 2024
Since
two-dimensionalal
(2D)
materials
have
distinct
chemical
and
physical
properties,
they
are
widely
used
in
various
sectors
of
modern
technologies.
In
the
domain
diagnostic
biodevices,
particularly
for
point-of-care
(PoC)
biomedical
diagnostics,
2D-based
field-effect
transistor
biosensors
(bio-FETs)
demonstrate
substantial
potential.
Here,
this
review
article,
operational
mechanisms
detection
capabilities
biosensing
devices
utilizing
graphene,
transition
metal
dichalcogenides
(TMDCs),
black
phosphorus,
other
2D
addressed
detail.
The
incorporation
these
into
FET-based
offers
significant
advantages,
including
low
limits
(LOD),
real-time
monitoring,
label-free
diagnosis,
exceptional
selectivity.
also
highlights
diverse
applications
biosensors,
ranging
from
conventional
to
wearable
devices,
underscoring
versatility
material-based
FET
devices.
Additionally,
provides
a
comprehensive
assessment
limitations
challenges
faced
by
along
with
insights
future
prospects
advancements.
Notably,
detailed
comparison
is
tabulated
platforms
their
working
mechanisms.
Ultimately,
aims
stimulate
further
research
innovation
field
while
educating
scientific
community
about
latest
advancements
materials-based
biosensors.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2025,
Volume and Issue:
13
Published: March 7, 2025
Diabetes
is
a
widespread
metabolic
disorder
that
presents
considerable
challenges
in
its
management.
Recent
advancements
biomaterial
research
have
shed
light
on
innovative
approaches
for
the
treatment
of
diabetes.
This
review
examines
role
biomaterials
diabetes
diagnosis
and
treatment,
as
well
their
application
managing
diabetic
wounds.
By
evaluating
recent
developments
alongside
future
obstacles,
highlights
promising
potential
care,
underscoring
importance
enhancing
patient
outcomes
refining
methodologies.
Talanta,
Journal Year:
2025,
Volume and Issue:
292, P. 127881 - 127881
Published: March 11, 2025
microRNAs
are
small
oligonucleotides
involved
in
post-transcriptional
gene
regulation
whose
alteration
is
found
several
diseases,
including
cancer,
and
therefore
their
detection
crucial
for
diagnosis,
prognosis,
treatment
purposes.
Field-Effect
Transistor-based
biosensors
(bioFETs)
represent
a
promising
technology
the
clinical
of
microRNAs.
However,
one
main
challenges
associated
with
this
Debye
screening,
becoming
significant
at
high
ionic
strengths
required
effective
hybridization.
We
aimed
detecting
oncogenic
microRNA-155
by
using
bioFET
system
as
capture
element
complementary
RNA
probe
(antimiR-155)
combined
introduction
PEG
molecules
(20
kDa,
PEG20),
an
strength
300
mM.
optimized
co-immobilization
ratio
between
antimiR-155
PEG20
assessed
its
impact
on
interactions
oligonucleotides.
The
kinetics
can
be
well
described
Langmuir-Freundlich
isotherm
affinity
constant
within
range
typical
nucleic
acid
interactions.
significantly
enhanced
sensitivity
miR-155
reaching
level
less
than
200
pM,
together
excellent
discrimination
against
other
clinically
relevant
Our
findings
demonstrate
that
incorporation
constitutes
strategy
to
mitigate
screening
effects
facilitates
bioFET-based
applications
physiological
strengths.
There
is
an
urgent
need
today
for
interface
management
with
recognition
layers
composed
of
short
receptor
molecules,
excellent
specificity
and
affinity
toward
a
target
molecule,
wide
range
sensing
applications.
The
current
work
demonstrates
specific
detection
G-type
nerve
agent,
which
based
on
nucleophilic
substitution
reaction
between
the
surface-bound
4-amino-2-((dimethylamino)methyl)phenol
(amino-2-DMAMP)
receptors
diethyl
chlorophosphate
(DCP)
simulant.
2-DMAMP
DCP
are
demonstrated
31P-nuclear
magnetic
resonance
(NMR)
electrospray
ionization
mass
spectrometry
(ESI-MS/MS).
proposed
layer
utilized
through
design
realization
electronic
chemosensor
using
meta-nanochannel
field-effect
transistor
(MNC
FET).
SiO2
area
MNC
FET
functionalized
amino-2-DMAMP
amine-based
chemistry,
response
quantified.
An
demonstrated,
coupled
limit
1
pg/mL,
dynamic
8
orders
magnitude,
linearity
sensitivity.
high
grade
pave
way
to
specific,
label-free,
quantitative,
low-cost,
easy-to-operate,
field-deployable
sensors.
Transition
metal
dichalcogenides
(TMDs)
have
emerged
as
groundbreaking
materials
in
the
field
of
biomedical
applications,
particularly
development
biosensors
and
medical
devices.
Their
unique
electronic
optical
properties,
combined
with
their
tunability
biocompatibility,
position
TMDs
promising
candidates
for
enhancing
early
disease
detection
enabling
personalized
medicine.
This
perspective
explores
multifaceted
potential
TMDs,
highlighting
applications
fluorescence
Raman-based
biosensing,
wearable
implantable
devices,
smart
therapeutic
systems
targeted
treatment.
Additionally,
we
address
critical
challenges
such
regulatory
hurdles,
long-term
stability,
ethical
considerations
surrounding
continuous
health
monitoring
data
privacy.
Looking
to
future,
envision
playing
a
vital
role
advancement
precision
medicine,
facilitating
real-time
individualized
treatments.
However,
successful
integration
into
clinical
practice
necessitates
interdisciplinary
collaboration
among
science,
bioengineering,
By
fostering
collaboration,
can
fully
harness
capabilities
revolutionize
healthcare,
making
it
more
accessible,
precise,
patients
worldwide.
Applied Physics A,
Journal Year:
2025,
Volume and Issue:
131(1)
Published: Jan. 1, 2025
The
objective
of
the
present
study
is
to
develop
a
novel
nanocomposite
platform
for
drug
delivery,
and
photothermal
therapy.
Molybdenum
disulfide
(MoS2)
nanosheet,
as
one
most
stable
transitional
metal
dichalcogenides,
indicates
unique
structure,
thermal,
optical
properties.
In
this
work,
MFC
was
synthesized
from
MoS2
nanosheets,
iron
oxide
(Fe3O4)
nanoparticles,
copper
monosulfide
(CuS)
nanoparticles.
Then
structural,
morphology,
properties
were
characterized
by
X-ray
diffraction
(XRD),
transmission
electron
microscopy
(TEM),
energy-dispersive
spectroscopy
(EDS),
fourier
transform
infrared
(FTIR),
ultraviolet-visible
(UV-Vis)
spectroscopies.
After
that,
experiment
done
with
different
concentrations
(50,
100,
150,
200,
400
ppm).
Photothermal
experiments
indicated
that
concentration
ppm
have
produced
highest
heat
(58.3
$$\:℃\:$$
)
after
10
min
near
(NIR)
laser
irradiation.
Then,
doxorubicin
(DOX)
loaded
into
nanocomposite.
It
further
studied
in-vitro
DOX
release
with,
without
Results
in
presence
NIR
irradiation
(1
W/cm2),
optimized
DOX/MFC
show
controlled
63.5%
pH
=
5.8
4
h.
Finally,
cytotoxicity
on
Hela
cells
assessed
using
an
MTT
assay.
result
assay
shows
69.9%
killed
at
µg/mL,
under
808
nm
concentrations.
illustrated
NIR-
radiation
W/cm2)
viability
decreased
when
increased
Therefore,
suggested
good
candidate
therapy,
delivery.
