Photocatalytic Enantioselective Radical Cascade Multicomponent Minisci Reaction of β‐Carbolines Using Diazo Compounds as Radical Precursors

Advanced Science, Journal Year: 2024, Volume and Issue: 11(25)

Published: April 19, 2024

Abstract Here, a photocatalytic asymmetric multicomponent cascade Minisci reaction of β‐carbolines with enamides and diazo compounds is reported, enabling an effective enantioselective radical C─H functionalization high yields enantioselectivity (up to 83% yield 95% ee). This protocol exhibits step economy, chemo‐/enantio‐selective control, good functional group tolerance, allowing access variety valuable chiral β‐carbolines. Notably, are suitable precursors in reactions. Moreover, the efficiency practicality this approach demonstrated by synthesis bioactive natural products.

Language: Английский

Photocatalytic Synthesis of Isoquinolinediones via the Cascade Reaction of N-Alkyl-N-methylacrylamides with Diazo Compounds

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Carbon radicals generated from acceptor diazo compounds prefer to add electron-rich olefins and heteroarenes due their containing electron-withdrawing groups. Herein, a cascade reaction of with electron-deficient is developed. In the presence visible light Ru catalyst, generate carbon via proton-coupled electron transfer process, followed by addition various N-alkyl-N-methylacrylamides subsequent cyclization give series acyl-substituted isoquinolinediones.

Language: Английский

Iron-Catalyzed C–H Arylphosphorylation of Quinoxalines

Organic Letters, Journal Year: 2024, Volume and Issue: 26(36), P. 7672 - 7677

Published: Sept. 4, 2024

A one-pot strategy for iron-catalyzed C2,3-H arylphosphorylation of electron-deficient quinoxalines with phosphines and aryl compounds is reported. The proposed method features the use non-noble metal catalysts, capacity utilizing multiple as substrates, simultaneous formation C-P C-C bonds in one pot, simplicity its operation, mildness reaction conditions, compatibility a wide range substrates. Moreover, it offers practical route direct access to 2-aryl-3-phosphino

Language: Английский