Supramolecular Assembly‐Enabled Transdermal Therapy of Hypertrophic Scarring Through Concurrent Ferroptosis‐Apoptosis DOI
Bin Zhao, Mengying Wei, Xiaomeng Zhou

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

Abstract Hypertrophic scar (HS) remains a major challenge for clinicians due to unsatisfactory therapeutic performance. Although inducing apoptosis of HS fibroblasts (HSFs) has proved be an effective nonsurgical treatment strategy, potential chemotherapy resistance HSFs makes the development new and efficient strategies highly demanding. Herein, ferroptosis‐apoptosis combined strategy is developed through supramolecular self‐assembly between cucurbit[7]uril (CB[7]) two bioactive agents, dihydroartemisinin (DHA) gold nanoclusters (AuNCs). The resulting self‐assembled nanoparticles, named CAD NPs, showed high guest loading efficiency prominent pH‐responsive degradability in acidic lysosomes HSFs. Importantly, both DHA AuNCs act synergistically generate excessive reactive oxygen species lipid peroxidation, leading mitochondrial damage, ultimately concurrent ferroptosis on Upon further into hydrogel microneedles facilitate their transdermal delivery, these NPs superior antiscar effects shortening span 3 weeks improving appearance, as demonstrated at rabbit ear model HS. present assembly‐based provides innovative guideline efficiently treating well other diseases.

Language: Английский

Through-Space Electron Effect Regulated Selective Expression of Ultralong Organic Room Temperature Phosphorescence and Photochromism DOI
Lin Han, Youshi Lan,

Xingda Zhang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

We report a through-space electron effect (TSEE) between two phosphorescent units that significantly modulates the selective expression of ultralong organic room-temperature phosphorescence (UORTP) and photochromism. A series molecules (DNapTr, DNapBNT, DNapFL, DNapPy), featuring connected by nonconjugated spacer, were synthesized. Our findings reveal both TSEE energy gap ΔE (defined as EPU2 - EPU1) lowest triplet levels (T1) play crucial roles in determining UORTP photochromic behavior PMMA films. NMR spectra molecular simulations confirm presence TSEE, with their strength ranked DNapPy < DNapFL DNapBNT TSEE. The DNap unit is governed where moderate inhibits radical cation formation, while strong promotes it. Consequently, DNapTr, exhibit tunable photochromism, whereas remains nonphotochromic. jointly influenced ΔE. For DNapTr (ΔE > 0), excitons are trapped via leading to from DNap. In slightly <0), directs PU2. ≪ enables Py. By leveraging tuning T1 PU2, we successfully modulated photochromism UORTP. This study provides strategy for designing intelligent materials.

Language: Английский

Citations

0
White light-excited organic room-temperature phosphorescence for improved in vivo bioimaging DOI Creative Commons

Lutong Zhang,

Ji-Sen Li, Y Zhang

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 28, 2025

Language: Английский

Citations

0
Aqueous/Chemical‐Resistant Organic Room Temperature Phosphorescence Materials From Siloxane Network Reinforcement DOI
Qipeng Zhang, Xiaohui Kang, Fan Yang

et al.

Advanced Optical Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Abstract Organic room‐temperature phosphorescent(RTP) materials typically exhibit superior luminescent properties, yet their instability, particularly in aqueous environments where phosphorescence is quenched, and under acidic, alkaline, or organic solvent conditions, restricts application. Herein, a novel convenient strategy designed for constructing host–guest RTP by incorporating silane into urea‐derived products to form siloxane network‐strengthened stable host matrix. The possesses excellent chemical stability can be combined with the thermolytic of urea through covalent bonds, enhancing resistance host. connects guest molecules bonds hydrogen restricting non‐radiative loss, phosphorescent emission, protecting from quenching multiple environments. material, prepared using (3‐aminopropyl) triethoxysilane, urea, 2‐aminoterephthalic acid, exhibits blue lifetime 891 ms, visible naked eye 21 s. Notably, it maintains emission water, solvents, strong acid/alkali solutions while demonstrating stability, as evidenced its potential applications afterglow displays information encryption. This provides valuable insights designing broadens application complex

Language: Английский

Citations

0
A polymer rigidity probe based on ultralong organic room temperature phosphorescence of a new skeleton benzo[4,5]imidazo[1,2-a]pyridine DOI

Jiaxin Ma,

Jingjuan Bai,

Lin Han

et al.

Journal of Materials Chemistry C, Journal Year: 2024, Volume and Issue: 12(39), P. 16035 - 16044

Published: Jan. 1, 2024

We report a new backbone, BNPy. Copolymerizing MA and AA with BNPy derivatives extended UORTP to over 10 s. For BNPy-1, the τ p is closely related trend of matrix T g . Thus, BNPy-1 can be used as an efficient polymer rigidity (or ) probe.

Language: Английский

Citations

1
Recent progress on exciplex-based organic long-persistence luminescent materials DOI Creative Commons
Wei‐Guang Wang,

Xin Zhang,

Fei He

et al.

Chinese Science Bulletin (Chinese Version), Journal Year: 2024, Volume and Issue: 69(26), P. 3849 - 3863

Published: June 25, 2024

纯有机长余辉材料具有分子结构/功能可调、易加工、不含重金属元素、生物相容性好、可大面积应用以及柔性等优点,在数据加密、生物成像、安全打印等领域得到了广泛的应用,是目前有机光电子学研究的热点之一。基于给体-受体构建的激基复合物长余辉材料具有发光持续时间长、制备简便以及性能可调等优点,成为设计、开发有机长余辉材料的新选择,近年来受到了人们的广泛关注。本文系统地综述了给-受体激基复合物长余辉材料的基本设计理念,并依据受体材料的不同,详细总结了各类高效、稳定的激基复合物长余辉材料体系,探讨了给体和受体分子间的相互作用对其发光持续时间的影响及其结构与性能的关系,总结了激基复合物有机长余辉材料存在的问题,并对其未来发展所面临的挑战和机遇进行了展望。

Citations

0
Luminous Fish‐Inspired Hydrogels with Underwater Long‐Lived Room Temperature Phosphorescence DOI

Panyi Chen,

Haofei Qie,

Xipeng Yang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 5, 2024

Abstract Some marine animals form long‐lived luminescence for predation, communication, camouflage, and anti‐predation. These demonstrate soft nature, sustainable glowing, underwater emission, which are difficult to achieve in synthetic room temperature phosphorescence (RTP) materials. Inspired by these animals, here the study reports RTP hydrogels that show (lifetime >500 ms afterglow >10 s) water. Exceptional mechanical properties simultaneously achieved, including tensile strength of 5.1 MPa, strain 452%, toughness 19.3 MJ m −3 . The key this achievement lies situ phase separation microarchitecture formed between polyacrylamide (PAM) its partial hydrolysates, confines motions polymer chains protects vulnerable triplet excitons from quenching Such a strategy shows merits facile fabrication without laborious synthesis. In addition, offer repeatable photoprinting highly stability water, providing versatile platform applications materials, information encryption camouflage animals.

Language: Английский

Citations

0
Carbazole Analog Doping‐Induced Bright Red and Near‐Infrared Organic Room‐Temperature Phosphorescence with Long Lifetime DOI
Xianhe Zhang, Zongliang Xie, Bin Liu

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 15, 2024

Abstract Materials with room‐temperature phosphorescence (RTP) from deep red to near‐infrared (NIR) region exhibit great potential for emerging applications. However, such molecules typically require a low‐lying first triplet (T 1 ) excited state, which may not be optimal exciton stabilization, potentially compromising the lifetime. This study reports design of four 9 H ‐carbazole (Cz) analogs extended conjugation lengths used as dopants achieve RTP emissions in and NIR regions lifetimes exceeding 700 ms. These findings reveal that substituting reactive hydrogen atoms Cz methyl groups significantly enhances photoluminescence quantum yield (PLQY) these materials compared their non‐methylated counterparts. Additionally, doping systems can activated by visible light, achieving persistent even under excitation 450 nm light. Theoretical calculations demonstrate crucial roles charge transfer state enhanced spin‐orbital coupling (SOC) matrix elements upon long‐lifetime beyond 600 nm. research presents strategy employing Cz‐based facilitate extending regions.

Language: Английский

Citations

0
Supramolecular Assembly‐Enabled Transdermal Therapy of Hypertrophic Scarring Through Concurrent Ferroptosis‐Apoptosis DOI
Bin Zhao, Mengying Wei, Xiaomeng Zhou

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

Abstract Hypertrophic scar (HS) remains a major challenge for clinicians due to unsatisfactory therapeutic performance. Although inducing apoptosis of HS fibroblasts (HSFs) has proved be an effective nonsurgical treatment strategy, potential chemotherapy resistance HSFs makes the development new and efficient strategies highly demanding. Herein, ferroptosis‐apoptosis combined strategy is developed through supramolecular self‐assembly between cucurbit[7]uril (CB[7]) two bioactive agents, dihydroartemisinin (DHA) gold nanoclusters (AuNCs). The resulting self‐assembled nanoparticles, named CAD NPs, showed high guest loading efficiency prominent pH‐responsive degradability in acidic lysosomes HSFs. Importantly, both DHA AuNCs act synergistically generate excessive reactive oxygen species lipid peroxidation, leading mitochondrial damage, ultimately concurrent ferroptosis on Upon further into hydrogel microneedles facilitate their transdermal delivery, these NPs superior antiscar effects shortening span 3 weeks improving appearance, as demonstrated at rabbit ear model HS. present assembly‐based provides innovative guideline efficiently treating well other diseases.

Language: Английский

Citations

0