Highly stable and near-infrared responsive phase change materials for targeted enzyme delivery toward cancer therapy DOI Creative Commons
Yuqiong Xia, Chang Liu,

Xuejuan Zhao

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101345 - 101345

Published: Nov. 19, 2024

Natural enzyme-based catalytic cascades have garnered increasing attention in cancer therapy, but their clinical utility is greatly limited due to loss of function during

Language: Английский

Light‐Activated In Situ Vaccine with Enhanced Cytotoxic T Lymphocyte Infiltration and Function for Potent Cancer Immunotherapy DOI Creative Commons

Xian An,

Zhuang Chen, Yi Luo

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(33)

Published: July 2, 2024

In situ cancer vaccination is an attractive strategy that stimulates protective antitumor immunity. Cytotoxic T lymphocytes (CTLs) are major mediators of the adaptive immune defenses, with critical roles in response and establishing memory, consequently extremely important for vaccines to generate systemic lasting efficacy. However, dense extracellular matrix hypoxia solid tumors severely impede infiltration function CTLs, ultimately compromising efficacy vaccines. To address this issue, a robust vaccine, Au@MnO

Language: Английский

Citations

7
DNA Nanostructures‐Based In Situ Cancer Vaccines: Mechanisms and Applications DOI Open Access
Bingyu Lin, Yanfei Liu, Qi‐Wen Chen

et al.

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Abstract Current tumor vaccines suffer from inadequate immune responsive due to the insufficient release of antigens, low infiltration, and immunosuppressive microenvironment. DNA nanostructures with their ability precisely engineer, controlled release, biocompatibility, capability augment immunogenicity microenvironment, have gained significant attention for potential revolutionize vaccine designing. This review summarizes various applications in construction situ cancer vaccines, which can generate tumor‐associated antigens directly damaged tumors immune‐stimulation. The mechanisms components are listed, specific strategies constructing using explored underlying action elucidated. immunogenic cell death (ICD) induced by chemotherapeutic agents, photothermal therapy (PTT), photodynamic (PDT), radiation (RT) related building systematically summarized. different immunotherapy elaborated, exerts precise, long‐lasting, robust responses. current challenges future prospectives proposed. provides a holistic understanding evolving role development.

Language: Английский

Citations

0
In Situ Vaccination Via Hypochlorous Acid-Activatable Nanoassemblies for Synergistic Cancer Immunotherapy DOI
Xiao Dong,

Shu Xia,

Mingzhi Wang

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Self-assembly GSH response based peptide-drug nanocombination synergistically promotes DNA damage for prostate cancer immunotherapy DOI

Maosong Hu,

Yuyu Zhu, Xinyi Tang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160862 - 160862

Published: Feb. 1, 2025

Language: Английский

Citations

0
Epigenetic nanoplatform for synergistic immune activation and immunogenicity restoration enhancing cancer radio-immunotherapy DOI

Zhenhu He,

Xiaopei Peng,

Jiong Li

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161177 - 161177

Published: March 1, 2025

Language: Английский

Citations

0
Growth of NIR-II-Responsive Gold Nanobipyramids with Improved Yield and a Study of Their Application in Cancer Therapy DOI
Yujie Ma, Liang‐Bin Xiong, Wenbin Qiu

et al.

Langmuir, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Gold nanobipyramids (Au NBPs), as a novel and emerging plasmonic nanomaterial, have shown larger local electric field enhancements, optical cross-sections, higher refractive index sensitivity compared to other nanoparticles. Besides, their localized surface plasmon resonance (LSPR) absorption can be tailored cover the entire NIR-II light region, which is crucial for clinical cancer treatment. However, strategies synthesize Au NBPs with an response still several disadvantages, such tedious procedures use of hazardous chemical substances. In this work, we used seed-mediated growth method explored new high-yield response, especially in region above 1030 nm, by regulating conditions during seed growth. The yield at 1060 nm has been improved 5-fold 6-fold previous methods when 230 μL sodium citrate or controlled temperature 45 °C were solution containing 125 NaBH4. influence mechanism these factors on detail. Furthermore, photodynamic photothermal behaviors LSPR investigated, results indicate that great potential therapy. proven induce immunogenic cell death (ICD), indicating immunotherapy. This work may provide idea synthesis biomedical applications response.

Language: Английский

Citations

0
Highly stable and near-infrared responsive phase change materials for targeted enzyme delivery toward cancer therapy DOI Creative Commons
Yuqiong Xia, Chang Liu,

Xuejuan Zhao

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101345 - 101345

Published: Nov. 19, 2024

Natural enzyme-based catalytic cascades have garnered increasing attention in cancer therapy, but their clinical utility is greatly limited due to loss of function during

Language: Английский

Citations

0