Hydrogel promotes bone regeneration through various mechanisms: a review DOI
Yuanyuan Zheng,

Ke Zheng,

Gang Hu

et al.

Biomedical Engineering / Biomedizinische Technik, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Abstract Large defects in bone tissue due to trauma, tumors, or developmental abnormalities usually require surgical treatment for repair. Numerous studies have shown that current repair and regeneration treatments certain complications limitations. With the in-depth understanding of mechanisms biological materials, a variety materials with desirable physicochemical properties functions emerged field recent years. Among them, hydrogels been widely used research their biocompatibility, unique swelling properties, ease fabrication. In this paper, development classification were introduced, mechanism promoting was described detail, including promotion marrow mesenchymal stem cell differentiation, angiogenesis, enhancement activity morphogenetic proteins, regulation microenvironment tissues. addition, future direction hydrogel engineering discussed.

Language: Английский

Injectable Biopolymer-Based Hydrogels: A Next-Generation Platform for Minimally Invasive Therapeutics DOI Creative Commons
Nargish Parvin, Sang Woo Joo, Tapas Kumar Mandal

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(6), P. 383 - 383

Published: May 23, 2025

Injectable biopolymer-based hydrogels have emerged as a powerful class of biomaterials designed for minimally invasive therapeutic strategies in modern medicine. These smart hydrogels, derived from natural biopolymers, such alginate, chitosan, gelatin, hyaluronic acid, and collagen, offer unique advantages, including biocompatibility, biodegradability, the ability to mimic extracellular matrix. This review provides comprehensive overview recent advancements design, crosslinking mechanisms, biofunctionality injectable tailored targeted drug delivery tissue regeneration. Special attention is given their role situ gelling systems, cancer therapy, musculoskeletal repair, neural Challenges related mechanical strength, degradation control, clinical translation are also discussed, along with future perspectives scalable manufacturing regulatory approval.

Language: Английский

Citations

0

Innovative Nanocomposite Scaffolds Containing ZIF-8 Nanoparticles for Improving Wound Healing: A Review DOI

Parinaz Nezhad‐Mokhtari,

Reza Rahbarghazi‬, Hamed Hamishehkar

et al.

Journal of Polymers and the Environment, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 17, 2024

Language: Английский

Citations

3

Integration of two-dimensional MXene into polymeric-based nanocomposite hydrogels for various biomedical applications: Recent Advances and Future Prospects DOI Creative Commons
Khurram Shahzad, Muhammad Asim Raza, Abrar Hussain

et al.

European Polymer Journal, Journal Year: 2024, Volume and Issue: unknown, P. 113512 - 113512

Published: Oct. 1, 2024

Language: Английский

Citations

3

Nanoparticle‐Mediated Gene Delivery for Bone Tissue Engineering DOI
Guangzhao Li, Jiaxin Wu, Xinting Cheng

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

Abstract Critical‐sized bone defects represent an urgent clinical problem, necessitating innovative treatment approaches. Gene‐activated grafts for tissue engineering have emerged as a promising solution. However, traditional gene delivery methods are constrained by limited osteogenic efficacy and safety concerns. Recently, organic inorganic nanoparticle (NP) vectors attracted significant attention in their safe, stable, controllable delivery. Targeted guided insights into healing mechanisms, coupled with the multifunctional design of NPs, is crucial enhancing therapeutic outcomes. Here, theoretical foundations underlying NP‐mediated therapy across different histological stages elucidated. Furthermore, distinct attributes functionalized NP discussed, cutting‐edge strategies aimed at optimizing efficiency throughout process highlighted. Additionally, review addresses unresolved challenges prospects this technology. This may contribute to continued development application treating critical‐sized defects.

Language: Английский

Citations

1

Adhesive and antibacterial guar gum-based nanocomposite hydrogel for remodeling wound healing microenvironment DOI
Weiwei Zhang, Qin He,

Ziming Jin

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 139054 - 139054

Published: Dec. 1, 2024

Language: Английский

Citations

1

Hydrogel promotes bone regeneration through various mechanisms: a review DOI
Yuanyuan Zheng,

Ke Zheng,

Gang Hu

et al.

Biomedical Engineering / Biomedizinische Technik, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Abstract Large defects in bone tissue due to trauma, tumors, or developmental abnormalities usually require surgical treatment for repair. Numerous studies have shown that current repair and regeneration treatments certain complications limitations. With the in-depth understanding of mechanisms biological materials, a variety materials with desirable physicochemical properties functions emerged field recent years. Among them, hydrogels been widely used research their biocompatibility, unique swelling properties, ease fabrication. In this paper, development classification were introduced, mechanism promoting was described detail, including promotion marrow mesenchymal stem cell differentiation, angiogenesis, enhancement activity morphogenetic proteins, regulation microenvironment tissues. addition, future direction hydrogel engineering discussed.

Language: Английский

Citations

0