Circ_0000215 Aggravates Cerebral Ischemic Vertigo by Targeting miR-361-3p to Promote Neuroinflammation and Apoptosis DOI Creative Commons
Sihua Qi, Feng Li, Lijun Yang

et al.

Journal of Stroke and Cerebrovascular Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 108317 - 108317

Published: April 1, 2025

Vertigo can result from cerebral ischemia (CI). Circular RNAs (cirRNA)'s role in CI is well-documented. This study focused on the clinical significance and mechanisms of circ_0000215 CI-induced vertigo. 120 patients 128 control participants were enrolled. During 90-day follow-up, 32.5% reported Mice models vertigo a cellular OGD/R-induced HT22 model constructed. RT-qPCR analyzed miR-361-3p expression. ROC curve analysis evaluated circ_0000215's predictive value for CI. ELISA assessed inflammatory factor levels, while CCK-8 flow cytometry cell proliferation apoptosis. Dual luciferase report RIP assays confirmed binding to miR-361-3p. levels significantly elevated patients, mice, OGD-induced cells, decreased. Elevated diagnosed predicted occurrence Additionally, Cox regression further that it an independent risk Inhibiting improved neurologic scores, shortened escape latency, increased blood but these effects reversed by downregulation Moreover, decreasing mitigated apoptosis inflammation, yet beneficial downregulation. Molecularly, targets aids diagnosis predicts It may promote inflammation targeting miR-361-3p, contributing nerve damage

Language: Английский

Circ_0000215 Aggravates Cerebral Ischemic Vertigo by Targeting miR-361-3p to Promote Neuroinflammation and Apoptosis DOI Creative Commons
Sihua Qi, Feng Li, Lijun Yang

et al.

Journal of Stroke and Cerebrovascular Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 108317 - 108317

Published: April 1, 2025

Vertigo can result from cerebral ischemia (CI). Circular RNAs (cirRNA)'s role in CI is well-documented. This study focused on the clinical significance and mechanisms of circ_0000215 CI-induced vertigo. 120 patients 128 control participants were enrolled. During 90-day follow-up, 32.5% reported Mice models vertigo a cellular OGD/R-induced HT22 model constructed. RT-qPCR analyzed miR-361-3p expression. ROC curve analysis evaluated circ_0000215's predictive value for CI. ELISA assessed inflammatory factor levels, while CCK-8 flow cytometry cell proliferation apoptosis. Dual luciferase report RIP assays confirmed binding to miR-361-3p. levels significantly elevated patients, mice, OGD-induced cells, decreased. Elevated diagnosed predicted occurrence Additionally, Cox regression further that it an independent risk Inhibiting improved neurologic scores, shortened escape latency, increased blood but these effects reversed by downregulation Moreover, decreasing mitigated apoptosis inflammation, yet beneficial downregulation. Molecularly, targets aids diagnosis predicts It may promote inflammation targeting miR-361-3p, contributing nerve damage

Language: Английский

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