Dyes and Pigments, Journal Year: 2025, Volume and Issue: unknown, P. 112823 - 112823
Published: April 1, 2025
Language: Английский
Dyes and Pigments, Journal Year: 2025, Volume and Issue: unknown, P. 112823 - 112823
Published: April 1, 2025
Language: Английский
Advanced Science, Journal Year: 2024, Volume and Issue: 11(38)
Published: Aug. 9, 2024
Fluorogens with aggregation-induced emission (AIEgens) are promising agents for two-photon fluorescence (TPF) imaging. However, AIEgens' photophysical properties fixed and unoptimizable once synthesized. Therefore, it is urgent meaningful to explore an efficient post-regulation strategy optimize properties. Herein, a general reported. By simply tuning the ratio of inert AIEgens within binary nanoparticles (BNPs), quantum yield absorption cross-section functional enhanced by 8.7 5.4 times respectively, which not achievable conventional strategies, notorious phototoxicity almost eliminated. The experimental results, theoretical simulation, mechanism analysis demonstrated its feasibility generality. BNPs enabled deep cerebrovascular network imaging ≈1.10 mm depth metastatic cancer cell detection single-cell resolution. Furthermore, TPF quality improved self-supervised denoising algorithm. proposed molecular opened new avenue efficiently boost consequently quality.
Language: Английский
Citations
4Journal of Biophotonics, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 5, 2025
ABSTRACT Two‐photon fluorescence (TPF) imaging opens a new avenue to achieve high resolution at extended penetration depths. However, it is difficult for conventional TPF systems simultaneously and speed. In this work, we develop an innovative deep learning framework of Lateral Axial Resolution Restoration (LARR) break the contradiction between LARR employs self‐supervised training scheme computationally restore sparsely sampled images isotropic by 4‐fold axial 16‐fold lateral enhancement. The simulation studies experimental results demonstrate excellent performance preserve fine structural features with improved signal‐to‐noise ratio structure similarity index. Moreover, system able 60‐fold speed comparable as compared system. outstanding makes potential tool fast resolution.
Language: Английский
Citations
0Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107752 - 107752
Published: April 1, 2025
Language: Английский
Citations
0Dyes and Pigments, Journal Year: 2025, Volume and Issue: unknown, P. 112823 - 112823
Published: April 1, 2025
Language: Английский
Citations
0