Review of Metal–Polyphenol Self-Assembled Nanoparticles: Synthesis, Properties, and Biological Applications in Inflammatory Diseases DOI
Huiying Li, Shuang Li, Jiawei Du

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Polyphenols, which are compounds characterized by the presence of phenolic hydroxyl groups, abundantly found in natural plants and exist highly complex forms within living organisms. As some most prevalent nature, polyphenols possess significant medicinal value due to their unique structural features, particularly therapeutic efficacy antitumor, anti-inflammatory, antibacterial applications. In context inflammation therapy, polyphenolic can inhibit excessive release inflammatory mediators from cells, thereby mitigating inflammation. Furthermore, these exhibit strong antioxidant properties, enabling them scavenge free radicals reactive oxygen species (ROS), reduce oxidative stress-related damage, exert anti-inflammatory effects. Due multiple groups ability chelate various metals, extensively utilized synthesis self-assembled nanoparticles for treatment diseases. Numerous studies have demonstrated that profile formed through self-assembly with metal ions surpasses alone. This Review will focus on different generate nanoparticles, characterization, applications inflammation-related diseases, providing researchers new insights into synthetic study metal-polyphenol nanocomposites biological

Language: Английский

New horizons for the therapeutic application of nanozymes in cancer treatment DOI Creative Commons
Pravanjan Malla, Yu‐Ming Wang, Chia‐Hao Su

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 20, 2025

The advent of nanozymes has revolutionized approaches to cancer diagnosis and therapy, introducing innovative strategies that address the limitations conventional treatments. Nanozyme nanostructures with enzyme-mimicking catalytic abilities exhibit exceptional stability, biocompatibility, customizable functions, positioning them as promising tools for theranostics. By emulating natural enzyme reactions, can selectively target eradicate cells, minimizing harm adjacent healthy tissues. Nanozymes also be functionalized specific targeting ligands, allowing precise delivery regulated release therapeutic agents, improving treatment effectiveness reducing adverse effects. However, issues such selectivity, regulatory compliance remain critical challenges clinical application nanozymes. This review provides an overview nanozymes, highlighting their unique properties, various classifications, activities, diverse applications in strategic oncological deployment could profoundly impact future advancements personalized medicine, recent progress prospective directions enzyme-mimetic treatment. summarizes

Language: Английский

Citations

2
Interlayer-engineered “six-in-one” nanozymes for cascade enzymatic/photothermal oncotherapy DOI
Zhenli Zhou, Danyang Li,

Linke Yu

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159189 - 159189

Published: Jan. 1, 2025

Language: Английский

Citations

0
Herbacetin as a Novel Ferroptosis Inhibitor for Mitigating Myocardial Damage Induced by Doxorubicin DOI
Hai Yang, Shaohong Huang,

Xinyu Heng

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
The Application and Molecular Mechanisms of Mitochondria-Targeted Antioxidants in Chemotherapy-Induced Cardiac Injury DOI Creative Commons

Chih-Jen Liu,

Lu‐Kai Wang, Fu‐Ming Tsai

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(3), P. 176 - 176

Published: March 7, 2025

Chemotherapeutic agents play a crucial role in cancer treatment. However, their use is often associated with significant adverse effects, particularly cardiotoxicity. Drugs such as anthracyclines (e.g., doxorubicin) and platinum-based cisplatin) cause mitochondrial damage, which one of the main mechanisms underlying These drugs induce oxidative stress, leading to an increase reactive oxygen species (ROS), turn damage mitochondria cardiomyocytes, resulting impaired cardiac function heart failure. Mitochondria-targeted antioxidants (MTAs) have emerged promising cardioprotective strategy, offering potential solution. efficiently scavenge ROS within mitochondria, protecting cardiomyocytes from damage. Recent studies shown that MTAs, elamipretide, SkQ1, CoQ10, melatonin, significantly mitigate chemotherapy-induced not only reduce but also help maintain structure function, stabilize membrane potential, prevent excessive opening permeability transition pore, thus preventing apoptosis dysfunction. In this review, we integrate recent findings elucidate cardiotoxicity highlight substantial therapeutic MTAs reducing are expected offer safer more effective treatment options for patients clinical practice.

Language: Английский

Citations

0
Bimetallic NiCu‐MOF Protects DOX‐Induced Myocardial Injury and Cardiac Dysfunction by Suppressing Ferroptosis and Inflammation DOI Open Access
Lu Liu,

Daiyong Chao,

Qing Dong

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Abstract Doxorubicin (DOX), a potent anthracycline chemotherapeutic agent, is widely used in cancer treatment but associated with significant adverse effects, particularly DOX‐induced cardiomyopathy (DIC). DIC pathogenesis involves the generation of reactive oxygen species (ROS) and ferroptosis induction. Novel therapeutic strategies targeting antioxidant defenses inhibition are essential for mitigating DIC. An innovative bimetallic metal‐organic framework (MOF), NiCu‐MOF (NCM), developed, exhibiting multifaceted enzyme‐mimicking activities that effectively scavenge broad spectrum ROS. Additionally, NCM exhibits excellent iron‐chelating ability. In vitro experiments demonstrate significantly reduces cardiomyocyte death by attenuating ROS levels inhibiting ferroptosis. Furthermore, mouse model DIC, results substantial myocardial protection, evidenced improved cardiac function structural integrity. This protective effect attributed to suppression ferroptosis, preservation mitochondrial function, attenuation inflammatory responses. Collectively, these findings highlight biocompatible NCM's potential as novel cardioprotective agent offer promising strategy managing

Language: Английский

Citations

0
SOD/CAT-biomimetic bioactive glass-ceramics nanozyme with intracellular oxygen supply and immunoregulation for MRSA-infected wound repair DOI
Tian Jing,

Yanzi Zhao,

Qingsong Zhang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162671 - 162671

Published: April 1, 2025

Language: Английский

Citations

0
Targeted intervention in obesity-associated atrial fibrosis using nanoparticle-loaded fusion protein DOI
Changying Wang, Xiaodong Zhang, Guangwei Zeng

et al.

APOPTOSIS, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Language: Английский

Citations

0
Review of Metal–Polyphenol Self-Assembled Nanoparticles: Synthesis, Properties, and Biological Applications in Inflammatory Diseases DOI
Huiying Li, Shuang Li, Jiawei Du

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Polyphenols, which are compounds characterized by the presence of phenolic hydroxyl groups, abundantly found in natural plants and exist highly complex forms within living organisms. As some most prevalent nature, polyphenols possess significant medicinal value due to their unique structural features, particularly therapeutic efficacy antitumor, anti-inflammatory, antibacterial applications. In context inflammation therapy, polyphenolic can inhibit excessive release inflammatory mediators from cells, thereby mitigating inflammation. Furthermore, these exhibit strong antioxidant properties, enabling them scavenge free radicals reactive oxygen species (ROS), reduce oxidative stress-related damage, exert anti-inflammatory effects. Due multiple groups ability chelate various metals, extensively utilized synthesis self-assembled nanoparticles for treatment diseases. Numerous studies have demonstrated that profile formed through self-assembly with metal ions surpasses alone. This Review will focus on different generate nanoparticles, characterization, applications inflammation-related diseases, providing researchers new insights into synthetic study metal-polyphenol nanocomposites biological

Language: Английский

Citations

0