Intelligent Nanomaterials Design for Osteoarthritis Managements

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: March 30, 2025

Osteoarthritis (OA) is the most prevalent degenerative joint disorder, characterized by progressive degradation, pain, and diminished mobility, all of which collectively impair patients' quality life escalate healthcare expenditures. Current treatment options are often inadequate due to limited efficacy, adverse side effects, temporary symptom relief, underscoring urgent need for more effective therapeutic strategies. Recent advancements in nanomaterials nanomedicines offer promising solutions improving drug bioavailability, reducing effects providing targeted benefits. This review critically examines pathogenesis OA, highlights limitations existing treatments, explores latest innovations intelligent design OA therapy, with an emphasis on their engineered properties, mechanisms, translational potential clinical application. By compiling recent findings, this work aims inspire further exploration innovation nanomedicine, ultimately advancing development personalized therapies.

Language: Английский

The advances in zwitterionic materials and their biomedical applications

International Materials Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: April 13, 2025

In recent years, zwitterionic materials have been widely used in biomedical and nanomedical due to their unique structure which the molecule is electrically neutral with equal positive negative charge. This kind of material could form a thick hydration layer by electrostatic effect, prevent contamination, show wide applications life science fields, such as resisting non-specific protein adsorption, biofilm, thrombosis formation, so on. Most importantly, diversity functional groups has made it more convenient for surface modification further utilization, creating multifunctional various applications. review summarized up-to-date materials, including conventional novel structural characteristics, well blood-contacting implantable devices, antibacterial coatings, wound dressings, drug-targeted carriers, smart wearable biosensors, especially clinical uses. New discoveries, existing challenges, commercial status are also outlined, future opportunities development perspectives new biomaterials demonstrated.

Language: Английский

Molecular Dynamics Investigation of the Shearing Behavior of Short-Chain Additives at Nanoscale Rough Ceramic/Polymer Interfaces: Implications for Biomedical Applications

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

The shearing behavior between ceramics and polymers is crucial for the performance of composite materials, especially in applications like total knee replacement, where it significantly impacts wear durability artificial joints. However, atomic evolution mechanism at interface during shear key influencing factors nanoscale are not fully understood. To address this, we use a molecular dynamics approach to model short PP chain additives SiO2/PP interface, focusing on underlying mechanisms under both smooth rough conditions. results show that with its roughness, induces significant deformation due hindering effect SiO2, whereas exhibits minimal deformation. As result, higher interfacial stress. study further examines impact finding increased roughness (larger amplitude or smaller wavelength) intensifies obstructive chain, leading larger Additionally, loading velocity considered. Within typical velocity, negligible, effects only occurring when exceeds several hundred meters per second. Finally, propose forming cross-linked network from short-chain can serve as an approximation long-chain discuss cross-linking. findings provide valuable insights into interfaces contribute understanding friction wear, particularly such replacement field biomedical applications.

Language: Английский