Free Cholesterol‐Induced Liver Injury in Non‐Alcoholic Fatty Liver Disease: Mechanisms and a Therapeutic Intervention Using Dihydrotanshinone I DOI Creative Commons
Jia‐Wen Shou, Juncai Ma, Xuchu Wang

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 12(2)

Published: Nov. 19, 2024

Abstract Build‐up of free cholesterol (FC) substantially contributes to the development and severity non‐alcoholic fatty liver disease (NAFLD). Here, we investigate specific mechanism by which FC induces injury in NAFLD propose a novel therapeutic approach using dihydrotanshinone I (DhT). Rather than ester (CE), observed elevated levels total cholesterol, FC, alanine transaminase (ALT) patients high‐cholesterol diet‐induced mice compared those healthy controls. The level demonstrated positive correlation with ALT both mice. Mechanistic studies revealed that reactive oxygen species level, impaired function lysosomes, disrupted lipophagy process, consequently inducing cell apoptosis. We then found DhT protected on an HCD diet, independent gut microbiota. functioned as potent ligand for peroxisome proliferator‐activated receptor α (PPARα), stimulating its transcriptional enhancing catalase expression lower (ROS) level. Notably, protective effect was nullified hepatic PPARα knockdown. Thus, these findings are first report detrimental role NAFLD, could lead new treatment strategies leveraging potential pathway.

Language: Английский

Drying methods affect nutritional value, amino acids, bioactive compounds, and in vitro function of extract in mulberry leaves DOI

Chengfeng Zhao,

Tao Li,

Cangning Zhang

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 144018 - 144018

Published: March 1, 2025

Language: Английский

Citations

0
Free Cholesterol‐Induced Liver Injury in Non‐Alcoholic Fatty Liver Disease: Mechanisms and a Therapeutic Intervention Using Dihydrotanshinone I DOI Creative Commons
Jia‐Wen Shou, Juncai Ma, Xuchu Wang

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 12(2)

Published: Nov. 19, 2024

Abstract Build‐up of free cholesterol (FC) substantially contributes to the development and severity non‐alcoholic fatty liver disease (NAFLD). Here, we investigate specific mechanism by which FC induces injury in NAFLD propose a novel therapeutic approach using dihydrotanshinone I (DhT). Rather than ester (CE), observed elevated levels total cholesterol, FC, alanine transaminase (ALT) patients high‐cholesterol diet‐induced mice compared those healthy controls. The level demonstrated positive correlation with ALT both mice. Mechanistic studies revealed that reactive oxygen species level, impaired function lysosomes, disrupted lipophagy process, consequently inducing cell apoptosis. We then found DhT protected on an HCD diet, independent gut microbiota. functioned as potent ligand for peroxisome proliferator‐activated receptor α (PPARα), stimulating its transcriptional enhancing catalase expression lower (ROS) level. Notably, protective effect was nullified hepatic PPARα knockdown. Thus, these findings are first report detrimental role NAFLD, could lead new treatment strategies leveraging potential pathway.

Language: Английский

Citations

2