Bimetallic Ca/Zn Nanoagonist Remould the Immunosuppressive Hepatocellular Carcinoma Microenvironment Following Incomplete Microwave Ablation via Pyroptosis and the STING Signaling Pathway DOI Creative Commons
Ling Yuan, Xiayi Liang,

Kangning Yan

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

During the treatment of solid tumors, local therapeutic approaches carry risk incomplete radical cure, which may lead to rapid tumor growth. Incomplete microwave ablation (iMWA) can induce tumors exhibit highly invasive and uncontrollable growth, is related immunosuppressive microenvironment. A multifunctional bimetallic Ca/Zn nanoagonist (PZH/Zn@CaNA) with a biomimetic liposome-modified surface tissues after iMWA developed. In response acidic microenvironment, released traditional Chinese medicine preparation Pien Tze Huang (PZH) reduced protein expressions JAK2-STAT3 signaling pathway, thereby slowing down proliferation growth hepatocellular carcinoma (HCC). Furthermore, ions Ca2⁺ Zn2⁺ cascade enhance killing effect oxidative stress, generating substantial amounts reactive oxygen species. This process induces pyroptosis releases significant quantities damage associated molecular patterns, triggering immune activation mechanisms STING pathway that reshape HCC microenvironment resulting from iMWA. strategy markedly differs previous chemoimmunotherapies, not only effectively addressed problem conventional drugs showing heterogeneous distribution in regions, but also verified critical role played by PZH/Zn@CaNA inhibiting iMWA-induced regulating stress remodeling

Language: Английский

The effect of ultrasound-guided microwave ablation on liver function and short-term efficacy in patients with postoperative recurrence of liver cancer DOI Creative Commons
Xiaodan Fu,

Lijie Gu,

Juan Xu

et al.

Current Problems in Surgery, Journal Year: 2025, Volume and Issue: 65, P. 101734 - 101734

Published: Feb. 6, 2025

Language: Английский

Citations

2
Nanomaterials in the diagnosis and treatment of gastrointestinal tumors: New clinical choices and treatment strategies DOI Creative Commons
Liping Chen,

Qingqing Li

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101782 - 101782

Published: April 19, 2025

Language: Английский

Citations

1
Bimetallic Ca/Zn Nanoagonist Remould the Immunosuppressive Hepatocellular Carcinoma Microenvironment Following Incomplete Microwave Ablation via Pyroptosis and the STING Signaling Pathway DOI Creative Commons
Ling Yuan, Xiayi Liang,

Kangning Yan

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

During the treatment of solid tumors, local therapeutic approaches carry risk incomplete radical cure, which may lead to rapid tumor growth. Incomplete microwave ablation (iMWA) can induce tumors exhibit highly invasive and uncontrollable growth, is related immunosuppressive microenvironment. A multifunctional bimetallic Ca/Zn nanoagonist (PZH/Zn@CaNA) with a biomimetic liposome-modified surface tissues after iMWA developed. In response acidic microenvironment, released traditional Chinese medicine preparation Pien Tze Huang (PZH) reduced protein expressions JAK2-STAT3 signaling pathway, thereby slowing down proliferation growth hepatocellular carcinoma (HCC). Furthermore, ions Ca2⁺ Zn2⁺ cascade enhance killing effect oxidative stress, generating substantial amounts reactive oxygen species. This process induces pyroptosis releases significant quantities damage associated molecular patterns, triggering immune activation mechanisms STING pathway that reshape HCC microenvironment resulting from iMWA. strategy markedly differs previous chemoimmunotherapies, not only effectively addressed problem conventional drugs showing heterogeneous distribution in regions, but also verified critical role played by PZH/Zn@CaNA inhibiting iMWA-induced regulating stress remodeling

Language: Английский

Citations

0