Unravelling the Role of PANoptosis in Liver Diseases: Mechanisms and Therapeutic Implications

Liver International, Journal Year: 2025, Volume and Issue: 45(4)

Published: March 21, 2025

PANoptosis is a multimodal form of cell death that involves inflammatory, apoptotic, and necroptotic pathways, playing key role in the development liver diseases. This article first outlines definition characteristics PANoptosis, then explores its mechanisms action different types diseases, including acute injury, failure, metabolic dysfunction-associated fatty disease, hepatocellular carcinoma. Furthermore, this analyses molecular regulatory network potential therapeutic targets. Finally, summarises current research on diseases future directions, it reviews emerging mechanism

Language: Английский

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Molecular mechanism of PANoptosis and programmed cell death in neurological diseases

Neurobiology of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 106907 - 106907

Published: April 1, 2025

PANoptosis represents a highly coordinated inflammatory programmed cell death governed by the assembly and activation of PANoptosome, which strategically integrate core molecular elements from pyroptosis, apoptosis, necroptosis. The triple-component pathways set themselves apart alternative regulated mechanisms through their unique capacity to concurrently process signals derived multiple death-signaling modalities, thereby coordinating multifaceted cellular defense system against diverse pathological insults. Pathogen-associated patterns synergistically interact with cytokine storms, oncogenic stress active PANoptosis, establishing this pathway as critical nexus in pathogenesis tumor immunomodulation. This crosstalk highlights promising therapeutic target for managing immune-related disorders malignant transformation. Emerging evidence links neuroinflammatory dysregulated between (apoptosis, necroptosis, pyroptosis) accidental necrosis, driving neuronal loss neural damage. Single-cell transcriptomics reveals spatially resolved signatures Alzheimer's hippocampal microenvironments sclerosis demyelinating plaques, distinct clusters correlating quantifiable metrics. PANoptosis-targeted therapies show preclinical promise alleviating neurovascular dysfunction while preserving physiological microglial surveillance functions. Accumulating linking (particularly PANoptosis) neurological underscores urgency deciphering its developing precision modulators next-generation therapies. review systematically deciphers PANoptosome associated cascades, evaluates roles multiscale regulatory networks, proposes frameworks advance neurology.

Language: Английский

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Integrated bulk RNA and single-cell analysis with experimental validation reveal oxidative stress-related diagnostic biomarkers for osteoporosis

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(4), P. e0322326 - e0322326

Published: April 29, 2025

Osteoporosis (OP) is a systemic skeletal disorder characterized by reduced bone mass and deterioration of microarchitecture, which increases fracture risk impairs physical function. This study explores the role CHRM2 in osteogenic differentiation evaluates its potential as biomarker for OP. Single-cell RNA sequencing revealed distinct differences cell type distributions between OP patients healthy controls, notably an increase M1 macrophages regulatory T cells patients. Functional enrichment analysis underscored involvement pathogenesis. Furthermore, was identified key gene associated with oxidative stress. In vitro experiments demonstrated that knockdown enhanced while suppressing proliferation, likely via interactions COL4A2. These findings suggest plays negative may serve both diagnostic therapeutic target early-stage

Language: Английский

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Rutin Attenuates Distraction Spinal Cord Injury by Inhibiting Microglial Inflammation Through Downregulation of P38 MAPK/NF-κB/STAT3 Pathway

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 19, 2024

Language: Английский

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