Targeted Sonodynamic Therapy Platform for Holistic Integrative Helicobacter pylori Therapy

Advanced Science, Journal Year: 2024, Volume and Issue: 12(2)

Published: Nov. 13, 2024

Helicobacter pylori (H. pylori) is a primary pathogen associated with gastrointestinal diseases, including gastric cancer. The increase in resistance to antibiotics, along the adverse effects caused by complicated medication protocols, has made eradication of H. more formidable challenge, necessitating alternative therapeutics. Herein, targeted nanoplatform reported based on sonodynamic therapy, chitosan-conjugated fucose loaded indocyanine green (ICG@FCS). It penetrates mucosa and homes through dual targeting mechanisms: molecular via physical ultrasound. Upon ultrasound activation, it generates singlet oxygen, effectively attacking planktonic bacteria, disrupting biofilms, facilitating clearance intracellular bacteria promoting autophagy, multidrug-resistant strains. ICG@FCS minimally affects gut microbiota aids repair. holistic integrative therapy strategy proposed that targets while preserving health. This emphasizes importance maintaining patient health eradicating pathogen. advancement set refine comprehensive antibacterial approach, offering promising horizon ongoing battle against antibiotic effective cancer prevention strategies.

Language: Английский

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Recent development of micro-nano carriers for oral antineoplastic drug delivery

Materials Today Bio, Journal Year: 2025, Volume and Issue: 30, P. 101445 - 101445

Published: Jan. 5, 2025

Chemotherapy is widely recognized as a highly efficacious modality for cancer treatment, involving the administration of chemotherapeutic agents to target and eradicate tumor cells. Currently, oral stands prevailing utilized method delivering chemotherapy drugs. However, majority anti-tumor medications exhibit limited solubility permeability, poor stability in harsh gastrointestinal environments, thereby impeding their therapeutic efficacy chemotherapy. Therefore, more micro-nano drug delivery carriers have been developed used effectively deliver anti-cancer drugs, which can overcome physiological barriers, facilitate administration, ultimately improve efficacy. In this paper, we first discuss effects various biological barriers on approach. Then, development based biomedical components, such micelles, dendrimers, hydrogels, liposomes, inorganic nanoparticles, etc. were introduced. Finally, current dilemma potential clinical treatment discussed. The primary objective review introduce methods serve point reference advancement novel carriers, with ultimate goal informing future applications.

Language: Английский

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Nanobiomaterials Based Sonodynamic Therapy for Treament of Helicobacter pylori Infections: A Review

Nano Biomedicine and Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Stem Cell Recruitment of Bionic Hydrogels Enhances Vascularized Bone Regeneration through Macrophage Reprogramming

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

The local inflammatory microenvironment, insufficient vascularization, and inadequate bone repair materials are the three key factors that constrain of defects. Here, we synthesized a composite nanoparticle, TPQ (TCP-PDA-QK), with core-shell structure. core consists nanotricalcium phosphate (TCP), shell is derived from polydopamine (PDA). surface modified vascular endothelial growth factor (VEGF) mimic peptide (QK peptide). was then embedded in porous methacrylate gelatin (GelMA) to form TPQGel hydrogel. In environment, hydrogel can gradually release drugs through pH responsiveness, promoting M2 macrophage polarization, vascularization regeneration turn. addition, reprogrammed macrophages stimulate generation anti-inflammatory pro-healing factors, which provide additional support for angiogenesis regeneration. not only accurately fill irregular defects but also possesses excellent mechanical properties biocompatibility, making it highly suitable minimally invasive treatment Transcriptomic tests revealed achieved reprogramming by regulating PI3K-AKT signaling pathway. Overall, be harnessed safe efficient therapeutics accelerate

Language: Английский

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An injectable multifunctional nanocomposite hydrogel promotes vascularized bone regeneration by regulating macrophages

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 7, 2025

Language: Английский

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