Oral Oncology, Journal Year: 2024, Volume and Issue: 159, P. 107088 - 107088
Published: Nov. 4, 2024
Language: Английский
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 14, 2025
Abstract Chemo‐immunotherapy, combining systemic chemotherapeutic drugs and immune checkpoint blockers, is a promising paradigm in cancer treatment. However, challenges such as limited induction of responses toxicity have hindered its clinical applications. Here, zeolite imidazolate framework‐8 (ZIF‐8) that encapsulates mitoxantrone (MIT), an cell death (ICD)‐inducing agent (MIT@ZIF‐8), synthesized using one‐pot aqueous‐phase process. ZIF‐8 serves dual‐functional nanomaterial for chemo‐immunotherapy: carrier to enhance tumor uptake MIT improved chemotherapy efficacy, pyroptosis inducer amplify MIT‐induced ICD augmented anti‐tumor responses. As result, vivo administration MIT@ZIF‐8 markedly inhibits growth both immunologically “hot” colon “cold” prostate cancer. Moreover, treatment increases the abundance cytotoxic CD8 + T cells reduces amount immunosuppressive regulatory tumors, thereby enhancing immunity sensitizing anti‐CTLA‐4 immunotherapy. In summary, offers highly translational approach chemo‐immunotherapy.
Language: Английский
Citations
0
Aging and Disease, Journal Year: 2025, Volume and Issue: unknown, P. 0 - 0
Published: Jan. 1, 2025
Nanozymes, which are nanomaterials that replicate the catalytic activities of natural enzymes in biological systems, have recently demonstrated considerable potential improving cancer immunotherapy by altering tumor microenvironment. Nanozyme-driven immune responses represent an innovative therapeutic modality with high effectiveness and minimal side effects. These nanozymes activate system to specifically recognize destroy cells. Combined immunotherapeutic agents, can amplify anti-cancer integrating remodeling immunogenic cell death (ICD). This review offers a thorough discussion about various involved immunity, including those mimicking catalase (CAT), superoxide dismutase (SOD), peroxidase (POD), oxidase (OXD). It also discusses challenges future directions for translating nanozyme platforms into clinical applications, enhancing susceptibility cells immunotherapy. Nanozyme-based strategies substantial oncology, offering new effective options management.
Language: Английский
Citations
0
Drug Development Research, Journal Year: 2025, Volume and Issue: 86(2)
Published: Feb. 27, 2025
ABSTRACT Owing to the presence of blood‐brain barrier and lack significant specificity towards tumor cells after entry into brain, unsuccessful delivery anticancer drugs treatment brain tumors. The hypothesis that cholesterol‐PEG co‐modified poly (N‐butyl) cyanoacrylate nanoparticles (CLS‐PEG NPs) are an effective carrier for tumors was verified, mechanism its preliminarily explored. In this study, we used multifunctional modified with cholesterol polyethylene glycol (PEG) as a drug system encapsulate docetaxel (DTX). Cell anti‐proliferation tests showed CLS‐PEG NPs increased inhibitory effect DTX. A pharmacokinetic study indicated achieved sustained release 8 h. These experimental results demonstrated amplified concentration transported in brain. addition, led better pharmacological efficacy orthotopic glioma rat model. survival rate rats group significantly prolonged 28 d. We also found inhibited M2 microglial polarization. indicate prospective targeting
Language: Английский
Citations
0
Small, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 28, 2025
Abstract Cancer remains one of the leading causes death individuals globally. Conventional treatment techniques like chemotherapy and radiation often suffer various drawbacks toxicity drug resistance. The study cell has been predominantly focused on classical forms apoptosis, but role metal ions in governing controlled is a fascinating less explored area. Metal‐mediated process where triggers via unique mechanism. Nanomaterial‐based strategies have gained attention for their ability to deliver precise therapeutic agents while also triggering Regulated Cell Death (RCD) mechanisms cancer cells. recently discovered metal‐mediated cuproptosis ferroptosis can be used as they selectively drug‐resistant cancer. Nano material‐based delivery system targeted sites. In this review, we given some idea about mechanism (ferroptosis cuproptosis) how initiate deaths using nanomaterials treatment.
Language: Английский
Citations
0
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: March 28, 2025
Currently, immunotherapy based on photothermal and the application of photodynamic therapy in anti-tumor treatment is showing great potential. Its uniqueness lies critical role small molecule immunomodulators promoting effective immune responses against tumors, use laser-activated biophysical mechanisms to precisely trigger swift demise cancer cells, avoiding damage surrounding normal tissues. However, (PDT) alone hampered by tumors' hypoxic environment, resulting poor antitumor effects, while (PTT) cannot arouse enough antigen presentation. It significance design photosensitizers (PSs) that possess both PDT PTT effects. Herein, a series PSs with efficacy are reported, ultimately selecting Cy7-Naph as star due its best overall phototherapeutic effect. Upon reactive oxygen species (ROS) production thermogenesis tumor induced significant apoptosis eventually boosted release damage-associated molecular patterns (DAMPs) under near-infrared (NIR) light irradiation. By combining Toll-like receptor agonist Resiquimod (R848), synergistic for bilateral tumor-bearing mice achieved. This combination promotes dendritic cell (DC) maturation increases infiltration cytotoxic T lymphocytes (CTLs), leading inhibition primary distant tumors.
Language: Английский
Citations
0
Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101745 - 101745
Published: April 1, 2025
Language: Английский
Citations
0
Oral Oncology, Journal Year: 2024, Volume and Issue: 159, P. 107088 - 107088
Published: Nov. 4, 2024
Language: Английский
Citations
0